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Ranitidine hydrochloride powder injection for injection

A technology of ranitidine and acid-base regulator, which is applied in powder delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of high early recurrence rate

Active Publication Date: 2013-09-25
CHENGDU TIANTAISHAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Smokers have a higher rate of early relapse

Method used

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  • Ranitidine hydrochloride powder injection for injection
  • Ranitidine hydrochloride powder injection for injection
  • Ranitidine hydrochloride powder injection for injection

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0142] Preparation example 1, preparation of powder injection comprising ranitidine

[0143] formula:

[0144] Ranitidine

100mg,

[0145] Mannitol

75 mg,

Glycine

15 mg,

pH regulator

to pH5.5,

Water for Injection

Appropriate amount, add to 2ml.

[0146] Preparation:

[0147] (1) Weigh the main drug (commercially available product, approved by the National Drug Administration H20065262; unless otherwise stated below, use this raw material drug) and excipients (except pH regulator) in the prescribed amount, put them in a stainless steel bucket, and add the prescribed amount About 80% water for injection, stir to dissolve, then add 0.1% (w / v) activated carbon according to the volume of the solution, stir for 30 minutes, filter and decarbonize, add water for injection to nearly the full amount of the prescription.

[0148] (2) The filtrate is sampled, and the pH value is measured. If necessary, it is adj...

preparation example 2

[0153] Supplementary Preparation Example 2: Referring to the method of Preparation Example 1 above, the difference is that the amount of glycine in it is adjusted to 0mg, 3mg, 7mg, 10mg, 14mg, 20mg, 25mg, 30mg, 50mg, and the number of the obtained powder injection is They are Ex121, Ex122, Ex123, Ex124, Ex125, Ex126, Ex127, Ex128, Ex129 respectively.

preparation example 3

[0154] Supplementary Preparation Example 3: Referring to the method of Preparation Example 1 above, the difference is that the amount of glycine is 10 mg, and the amount of mannitol is 0 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, and 200 mg. The numbers of the obtained powder injections are Ex131, Ex132, Ex133, Ex134, Ex135, Ex136, Ex137.

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Abstract

The invention relates to a ranitidine hydrochloride powder injection for injection, specifically to a pharmaceutical composition. The ranitidine hydrochloride powder injection contains ranitidine, a freeze-drying excipient and an optional acidifying or alkalizing agent. The invention also relates to a preparation method of the pharmaceutical composition. The pharmaceutical composition, which is used as an excellent and potent histamine H2 receptor antagonist, can be used to effectively inhibit gastric acid secretion caused by stimulation of histamine, pentagastrin and carbechal, reduce gastric acid and gastric enzyme activity, and is an excellent gastropathy medicine for treating hyperacidity and heartburn. The powder injection provided by the invention has good pharmaceutical properties.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a potent histamine H2 receptor antagonist, which can effectively inhibit the secretion of gastric acid stimulated by histamine, pentagastrin and carbachol, and reduce gastric acid and The gastric enzyme activity is mainly used as an excellent stomach disease drug for the treatment of hyperacidity and heartburn, and in particular relates to a ranitidine hydrochloride powder injection for injection, which has good pharmaceutical properties. Background technique [0002] The ranitidine involved in the present invention (used clinically with its hydrochloride, when referring to ranitidine in the present invention, if not otherwise specified, all refer to its hydrochloride, Ranitidine Hydrochloride) is a kind of It can effectively inhibit the secretion of gastric acid stimulated by histamine, pentagastrin and carbamylcholine, and reduce the activity of gastric acid a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/341A61K47/26A61K47/18A61P1/04
Inventor 赵东明贾红军方专丁多浩董国明
Owner CHENGDU TIANTAISHAN PHARMA
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