205 results about "Polysorbate 80" patented technology

The present invention relates to the technical field of pharmaceutical preparations, and specifically discloses a beclomethasone dipropionate suspension for inhalation and a preparation method thereof. The present invention uses polyethylene glycol hyaluronic acid as a surfactant, polysorbate 80 (II) as a wetting agent, and colloidal microcrystalline cellulose as a suspending agent, first prepares an auxiliary material solution containing part of the surfactant, the wetting agent and the suspending agent, and a drug solution of beclomethasone dipropionate and the surfactant, and then mixes the drug solution with the auxiliary material solution and homogenizes under high pressure to prepare the beclomethasone dipropionate suspension for inhalation. The prepared beclomethasone dipropionate suspension has excellent storage stability and effective lung deposition rate, effectively solves the potential harm to respiratory tissue caused by the use of a large amount of Tween 20 and Span-type surfactants in the original research, can achieve a good replacement for the original research product, and has a simple preparation process, good repeatability, and is easy to achieve industrialized large-scale production, and has a high value of promotion and application.

The invention belongs to the technical field of biological medicine, and particularly discloses a composite vaccine adjuvant as well as a preparation method and application thereof. The composite vaccine adjuvant provided by the invention is an oil-in-water emulsion, and simultaneously contains squalene, polysorbate 80, sorbitan trioleate, polyinosinic acid (Poly I: C) and CpG oligodeoxynucleotide (CpG-ODN). The sequence-optimized CpG-ODN and Poly I: C are used in a specific emulsion system in a combined mode, a remarkable synergistic immune enhancement effect can be generated, the induced humoral immunity and cellular immunity response level is remarkably higher than the sum of the effects when all the components are independently used, and the composite adjuvant is good in stability, high in immunostimulatory activity and suitable for clinical application. The immune effect can be remarkably improved by combined application with various vaccine antigens. The invention also provides a preparation method and application of the composite vaccine adjuvant.

The invention provides an anti-freezing denaturation agent for golden and tiger hybrid spotted fish meat protein and a preparation method of the anti-freezing denaturation agent. The invention relates to an anti-freezing denaturation agent for protein of Jinhu hybrid spotted fish. The anti-freezing denaturation agent is prepared from the following raw materials in parts by weight: 5 to 8 parts of trehalose-mannitol, 0.5 to 1 part of nano chitosan, 0.2 to 0.5 part of rosmarinic acid and 0.1 to 0.2 part of polysorbate-80. The trehalose-mannitol is prepared from trehalose and mannitol. Aiming at the characteristics of Jinhu hybrid spotted fish meat, trehalose-mannitol, nano chitosan, rosmarinic acid and polysorbate-80 are taken as raw materials and compounded to obtain a new formula of the protein anti-freezing denaturation agent for the Jinhu hybrid spotted fish meat, and the anti-freezing denaturation agent prepared by adopting the formula and the process disclosed by the invention can be used for inhibiting protein degradation and improving the anti-freezing denaturation effect of the Jinhu hybrid spotted fish meat. The decrease range of MP protein concentration, MP total sulfydryl content and MP Ca < 2 + >-ATPase activity of the antifreeze agent is obviously reduced, and the effect of the antifreeze agent is superior to that of a commercially available antifreeze agent. Moreover, the anti-freezing denaturation agent for the protein of the Jinhu hybrid spotted fish does not contain phosphorus, and has the advantages of safety and high efficiency.

The invention relates to a string maintenance nanoemulsion and a preparation method thereof, and belongs to the technical field of string maintenance. The nanoemulsion comprises polysorbate 80 and sorbitan stearate 60 as main emulsifiers, glyceryl monostearate, cetyl alcohol and stearyl alcohol as auxiliary emulsifiers, liquid paraffin and xanthan gum for adjusting the consistency, chitosan-loaded sodium hyaluronate nanoparticles as a long-acting humectant, and glycerol and propylene glycol as humectants and also can be used as anti-freezing agents. Ethylparaben is used as a preservative; and essence and the balance of water can be selectively added. Uniformly mixing and stirring the water-soluble components; uniformly mixing and stirring oil soluble components; and adding the oil phase into the water phase, stirring to form primary emulsion, emulsifying, homogenizing, cooling, and adding essence to obtain the product. According to the invention, the chitosan-loaded sodium hyaluronate nanoparticles are introduced to realize long-acting moisturizing and moistening of strings, and have the advantages of fine and soft texture and the like.

The claimed group of inventions relates to a field of veterinary medicine and concerns a water-soluble supramolecular complex with afoxolaner, a method for production thereof, and veterinary drugs comprising said complex as a main active component to prevent or to treat parasite infections in animals. The inventive complex is a fine powder having a particle size of less than 1 micron that is an inclusion of afoxolaner molecules into the structure of 2-hydroxypropyl-β-cyclodextrin, stabilized by polysorbate 80 and may be used in veterinary drugs having antiparasite effect for effective oral and parenteral administration.

The present invention relates to a composition of a ready to mix drink with green coffee extract as the main component. The current embodiment of our present invention includes three types of composition to provide flavour difference. Namely, mocha coffee, roasted coffee and cappuccino coffee flavour. The main components of the composition include the following ingredients in all the variants namely green coffee extract (50%), pullulan, propylene glycol, maltodextrin, polyethylene oxide, glycerol, polysorbate 80, sorbitol, nuesilin UFL2. Di basic calcium phosphate anhydrous, with only the flavoring agent as the changeable component to the composition.

The invention discloses food-grade metal surface blackening liquid as well as a blackening process and application. The blackening liquid comprises a basic blackening component and a modified graphene solution, wherein the basic blackening liquid comprises 15-25 g / L of sodium pyrophosphate, 8-12 g / L of sodium molybdate, 20-30 g / L of sodium gluconate, 2-5 g / L of sodium erythorbate, a citric acid / sodium citrate buffer solution, 10-15 ml / L of polyethylene glycol and 0.5-1 ml / L of polysorbate 80; the modified graphene is PEI modified graphene oxide. According to the method, stubborn dirt is cleaned and peeled off through ultrasonic waves, and grease is degraded through photocatalysis of nano TiO2, so that the surface hydrophilicity is improved, and the adsorption uniformity of blackening liquid is enhanced; according to the method, Si-O-Si network crosslinking is optimized through staged heating (80 DEG C to 120 DEG C to 140 DEG C), the hardness and the adhesive force are improved, thermal stress concentration in a traditional process is avoided, meanwhile, raw material decomposition can be avoided at the temperature, and the safety of blackening liquid is further guaranteed.

The invention provides a docetaxel-loaded platelet delivery system as well as a preparation method and application thereof, and relates to the technical field of medicines. According to the invention, the docetaxel-loaded platelet delivery system is obtained by loading the docetaxel with the platelets for the first time, so that the problem that in the prior art, the traditional docetaxel preparation (injection) needs to be solubilized by polysorbate 80, so that allergy is easily caused is avoided, the safety and biocompatibility of the docetaxel medicine are improved, and the docetaxel-loaded platelet delivery system is suitable for clinical application. And the docetaxel-loaded platelet delivery system has excellent stability and can be stored at normal temperature for a long time. The invention provides the preparation method of the docetaxel-loaded platelet delivery system, and the method is simple to operate, high in encapsulation efficiency and drug loading rate and suitable for popularization. The docetaxel-loaded platelet delivery system disclosed by the invention has an outstanding treatment effect on melanoma and has a good application prospect.

Provided are pharmaceutical formulations comprising a recombinant acid α-glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa; at least one buffer selected from the group consisting of a citrate, a phosphate and combinations thereof; and at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the formulation has a pH of from about 5.0 to about 7.0. Also provided are methods of treating Pompe disease using these pharmaceutical formulations.

The invention discloses a composite adjuvant, and belongs to the field of vaccine adjuvants. The main active components of the composite adjuvant are squalene, polysorbate 80 and monophosphoryl ester A, the composite adjuvant is in an oil-in-water emulsion form, nano-scale emulsion droplet particles are uniformly distributed in a water phase, and the system is stable. The invention also discloses a preparation method of the composite adjuvant based on a stirring method. The composite adjuvant comprehensively utilizes the dual characteristics of the oil-in-water emulsion and the immunopotentiator, and can induce a higher level of immunoreaction when being combined with the antigen, so that the composite adjuvant can be used for preparing vaccines and improving the effectiveness of the vaccines.

The invention provides stable liquid formulation of anti-α4β7 antibody comprising buffer, viscosity reducer, and surfactant, wherein the viscosity reducer is L-arginine hydrochloride and surfactant is polysorbate 80, wherein formulation does not contain any anti-oxidant. The stable citrate free liquid formulation according to present invention is suitable for subcutaneous administration.

Pharmaceutical composition comprising one or more cannabinoids (e.g., cannabidiol; 15-25 % w / w), one or more cyclodextrins or cyclodextrin derivatives (e.g., α-cyclodextrin (alpha-CD) or hydropropyl-β

The invention relates to the technical field of biological pharmacy, and discloses a preparation method of a ready-to-use stable 3D-MLA adjuvant solution, which comprises the following steps: dissolving citric acid monohydrate and trisodium citrate dihydrate in water for injection to prepare a citrate buffer solution; adding polysorbate 80 into the citrate buffer solution while stirring, and dissolving the polysorbate 80; adding 3D-MLA into the obtained solution under stirring, and dissolving the 3D-MLA; adjusting the pH value of the solution; fixing the volume by using water for injection; sterilizing and filtering through a filter membrane, filling a container with filtrate, and sealing; and refrigerating and storing. According to the present invention, the citrate buffer solution is adopted, the pH value of the adjuvant solution is adjusted, and the combination effect of the buffer system and the pH environment is utilized, such that the chemical degradation of the 3D-MLA in the injection water is effectively inhibited, the technical problem that the solution is easily degraded is solved, and the ready-to-use preparation capable of maintaining the stability under the refrigeration storage condition is obtained.

A noninvasive ophthalmic formulation, comprising a chelator (such as EDTA and its salts), a transport enhancer (such as Methyl Sulfonyl Methane; MSM), a second permeation enhancer such as propylene glycol, a thickening agent such as hydroxyethyl cellulose (HEC) and a surfactant such as polysorbate 80, is provided. The novel combination of the ingredients unexpectedly and beneficially reduces symptoms associated with early-stage, age-related cataracts. Methods for treating cataracts with compositions of the invention and measurement of improved visual function by measuring contrast sensitivity (CS) are provided.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The application discloses a kind of bumetanide tablets, raw materials include bumetanide 1 according to mass ratio;Corn starch 81~85;Lactose 50~54;Agar 0.1~0.3;Povidone K304~6;Polysorbate 80, 0.1~0.2;Silicon dioxide 3~4.5;Talcum powder 2~3.3;Magnesium stearate 0.3~0.7.Its preparation method includes the following steps: pretreatment, premixing, granulation, wet granulation, drying, dry granulation, total mixing, tabletting and packaging.The application introduces the synergistic system of trace agar and polysorbate 80 in the prescription.Agar, as a natural hydrophilic colloid, can form a hydrophilic network structure during the granulation process, and synergistically act with polysorbate 80, greatly improving the wettability and dispersibility of the slurry to ultrafine bumetanide, preventing drug agglomeration, so that the drug can be more evenly distributed in the granules during the subsequent drying and tabletting process.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The present application relates to string maintenance nanoemulsion and its preparation method, belong to string maintenance technical field. The nanoemulsion includes: polysorbate 80, stearic acid sorbitan 60 as main emulsifier, glycerin monostearate, cetyl alcohol, stearyl alcohol as auxiliary emulsifier, liquid paraffin, xanthan gum adjusts consistency, chitosan carries sodium hyaluronate nanoparticle as long-acting moisturizing agent, glycerol, propylene glycol is humectant and can be used as antifreezing agent; hydroxyphenyl ethyl as preservative; can also selectively add essence, the balance is water. The water-soluble ingredients are mixed and stirred uniformly; the oil-soluble ingredients are mixed and stirred uniformly; the oil phase is added to the water phase, and the primary emulsion is stirred and emulsified, and the essence is added after cooling, and the present application is obtained. The present application realizes long-acting moisturizing and nourishing of the string by introducing chitosan carrying sodium hyaluronate nanoparticles, and has the advantages of fine texture, softness and the like.

Compositions and methods for removing a first detergent or surfactant from an aqueous solution by adding a second detergent or surfactant at a concentration exceeding the critical micelle concentration (CMC) of the second detergent or surfactant are described. These compositions and methods are particularly suitable for solutions containing proteins. Typical first detergents / surfactants include polysorbate 20, polysorbate 80, and Triton X-100. Suitable second detergents or surfactants can be ionic, nonionic, or zwitterionic. Typical second detergents / surfactants include, but are not limited to, galactoside detergents (e.g., octyl-β-galactoside), glucoside detergents (e.g., MEGA8, MEGA9, MEGA10), cholamide detergents (e.g., CHAPS, CHAPSO, BIGCHAPS), and sulfobetaine detergents (e.g., sulfobetaine 3-10).

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a cyclodextrin inclusion compound and a preparation method thereof.The cyclodextrin inclusion compound comprises voriconazole, a cosolvent and sulfobutyl-beta-cyclodextrin, by increasing use of the cosolvent polysorbate 80 (II), the use amount of sulfobutyl ether-beta-cyclodextrin in voriconazole for injection is reduced, and the content of the sulfobutyl ether-beta-cyclodextrin in voriconazole for injection is reduced; the invention aims at remarkably reducing cyclodextrin accumulation in the body and provides guarantee for medication safety of patients with moderate to severe renal function impairment. Meanwhile, the preparation process is simple, industrial production is facilitated, and the inclusion effect of the inclusion compound and the stability of the product can be guaranteed.

The invention provides a preserving fluid for preserving adipose tissue-derived stem cell extracellular vesicles and a formula of a corresponding preparation, and particularly, the formula comprises sodium chloride, cane sugar, polysorbate 80, histidine and histidine hydrochloride. According to the formula, the storage stability of the extracellular vesicles secreted by adipose tissue can be improved, substances in the extracellular vesicles are prevented from being degraded, convenience is provided for clinical application of the extracellular vesicles, and good market prospects are achieved.

The invention discloses a method for detecting polysorbate 80 based on an MALDI-MS and UHPLC-Q-TOF / MS. The method comprises the following steps: taking a polysorbate 80 sample, preparing a polysorbate 80 solution by using acetonitrile, respectively carrying out MALDI-MS detection and UHPLC-Q-TOF / MS detection on the polysorbate 80 solution, and determining the content of the polysorbate 80 in the polysorbate 80 sample according to the MALDI-MS and UHPLC-Q-TOF / MS detection results. The method comprises the following steps: acquiring PS80 principal component distribution according to an MALDI-MS (Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry) map: a polyoxyethylene chain delta m / z 44.0 + / -0.2 and an esterified derivative sodium adduct ion gradient peak cluster, and carrying out qualitative analysis on components of the polysorbate 80 in combination with a characteristic interval of m / z 44.0 + / -0.2 in the MALDI map; according to the retention time in the UHPLC-Q-TOF / MS detection result, identifying the monoester, diester and trace unesterified sorbitan in the polysorbate 80. According to the invention, molecular weight distribution analysis and component separation and identification of PS80 are realized.

Pharmaceutical aerosol formulations containing pre-micronized albuterol sulfate, high amount of green propellant trans-1,3,3,3-tetrafluoropropene (HFO-1234ze(E)), and a surfactant (polysorbate 80 (polyoxyethylene (20) sorbitan monooleate), polysorbate 20 (polyoxyethylene (20) sorbitan monolaurate), polyethylene glycol 1000, span 85 (sorbitan trioleate), polyvinylpyrrolidone K25, or their combination) in a pressurized metered dose inhaler are described. The formulations do not use any co-solvent, i.e., they are co-solvent-free (e.g., free of ethanol, glycerol, propylene glycol, and a combination thereof). The formulations provide highly efficient delivery, through metered dose inhaler (MDI), of pre-micronized albuterol particles into the patients' respiratory tracts and have the advantages of high efficacy, improved safety, and a low global warming potential (GWP) for environmental impact.

A noninvasive ophthalmic formulation, comprising a chelator (such as EDTA and its salts), a transport enhancer (such as Methyl Sulfonyl Methane; MSM), a second polyoxyalkylene permeation enhancer such as propylene glycol capable of enhancing permeation through lipid-thickened ocular membranes, a thickening agent such as hydroxyethyl cellulose (HEC) and a surfactant such as polysorbate 80, is provided. The novel combination of the ingredients unexpectedly and beneficially reduces symptoms associated with early-stage, age-related cataracts. Methods for treating cataracts with compositions of the invention and measurement of improved visual function by measuring contrast sensitivity (CS) are provided.

The invention discloses a chlorhexidine gluconate gargle and a production process thereof. The chlorhexidine gluconate gargle is prepared from chlorhexidine gluconate, glycerol, polysorbate 80, menthol, saccharin sodium salt, a buffer solution, xanthan gum, lactoferrin peptide and a compound extract, according to the invention, by adding the lactoferrin peptide and the compound extract, the inhibition effect on oral bacteria can be enhanced, the overall flavor of the gargle can be improved, meanwhile, good antibacterial and anti-inflammatory effects can be provided, mucous membrane tissues can be helped to be repaired when oral mucosa is damaged, and the practicability of the product is improved; in the process of dissolving chlorhexidine gluconate, ultrasonic-assisted treatment is carried out by using ultrasonic equipment, so that the dissolution of chlorhexidine gluconate is promoted, the dissolution efficiency is improved, and the uniformity of solution mixing is guaranteed; before the gargle is filled, the gargle is sterilized by using cold plasma, and structures such as cell walls, cell membranes and nucleic acids of residual microorganisms are destroyed, so that efficient sterilization is realized, and the storage time of the gargle is prolonged.

The application discloses a virus-like particle vaccine freeze-drying protective agent and a preparation method thereof. The freeze-drying protective agent comprises A liquid and B liquid mixed in a volume ratio of 1:1 to 3:1; the A liquid comprises the following components with terminal concentrations: 0.01-0.5 mol / L base liquid I, 0.5-2 mmol / L base liquid II, 0.01-0.1% polysorbate 80, 5-20% sucrose and 1-5% trypsin; and the B liquid comprises the following components with terminal concentrations: 0.1-5% trehalose, 0.1-5% oligogalactose and 0.1-2% PEG6000. Through the compounding of the A liquid and the B liquid, the application can effectively enhance the immunization effect of the vaccine, prolong the storage time of the vaccine and keep the virus-like particle form intact.

The invention discloses an interface regulation and control wetting oil displacement agent for improving the recovery ratio of a low-permeability oil field, and the interface regulation and control wetting oil displacement agent comprises the following components in parts by weight: 6-10 parts of dimethylol lauryl sodium sulfate, 2-5 parts of polysorbate-80, 2-4 parts of nanoscale titanium dioxide, 1-2 parts of ethanol and 100-120 parts of deionized water. The interface regulation and control wetting oil-displacing agent can effectively enhance the adsorption effect of the oil-displacing agent on the rock surface, so that the wetting regulation and control capability is improved, and the recovery efficiency of a low-permeability oil field is remarkably enhanced by changing the wettability of the rock surface and an oil-water interface and optimizing distribution and flowing of fluid in pores.

The present invention discloses an emulsification-aiding hydrophobic adjuvant, a synthesis method, and applications thereof. The adjuvant is composed of Fmoc-amino acids and their derivatives and fatty acid chains formed thereon. As the emulsification-aiding hydrophobic adjuvant, the Fmoc-amino acids and their derivatives are partially used to bind to hydrophobic active drugs, and the fatty acid chains are used to embed into the molecules to be emulsified. Utilizing this emulsification-aiding hydrophobic adjuvant can effectively improve the stability of albumin nanoformulations of drugs such as docetaxel, thereby facilitating the preparation of corresponding high-concentration products. Furthermore, such albumin nanoformulations do not contain hemolytic adjuvants such as polysorbate 80 and ethanol, eliminating the risk of hemolysis and enabling better drug effects.

The invention discloses a stable levocetirizine hydrochloride eye drop composition and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The composition is prepared from levocetirizine hydrochloride, glycerol, polyethylene glycol 400, polysorbate 80, edetate disodium, benzalkonium chloride, hydroxypropyl methylcellulose, sodium dihydrogen phosphate, sodium hydroxide, hydrochloric acid and water. The composition is simple in preparation method, the pH value and osmotic pressure molar concentration of the composition are similar to those of tears, and the composition is free of irritation, good in medication comfort and good in stability during storage.