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Famotidine calcium magnesium chewable tablet

A famotidine and chewable tablet technology, applied in the field of medicine, can solve the problems of difficulty in compound chewable tablets, sensitivity to chemical stability of famotidine, etc.

Active Publication Date: 2014-10-15
YANTAI RONGCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In the above-mentioned compound chewable tablets, in view of the amount of calcium carbonate up to 800mg and the amount of magnesium hydroxide up to 165mg in each tablet, and the amount of only famotidine 10mg, and the chemical stability of famotidine is relatively sensitive, Therefore, there are many technical difficulties in preparing this compound chewable tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Embodiment 1: Preparation of Famotidine Calcium and Magnesium Chewable Tablets

[0154] prescription:

[0155] Famotidine 10mg,

[0156] Calcium Carbonate 800mg,

[0157] Magnesium Hydroxide 165mg,

[0158] Sucralose 5mg,

[0159] Sorbitol 50mg,

[0160] Lactose 100mg,

[0161] Starch 110mg,

[0162] Carmine Aluminum Lake 0.5mg,

[0163] Sucrose Powder 356mg,

[0164] Peppermint Oil 4mg,

[0165] Povidone K-30 (10% solution) appropriate amount,

[0166] Orange essence 5mg,

[0167] Magnesium Stearate 30mg.

[0168] Preparation method: each raw and auxiliary material is crushed separately, and passed through a 120-mesh sieve;

[0169] (1) prepare povidone solution, for subsequent use;

[0170] (2) each solid material is pulverized respectively, crosses 120 mesh sieves;

[0171] (3) Take the peppermint oil and starch of the prescribed amount, mix them evenly, place them for one day, and set them aside;

[0172] (4) Get the famotidine, sucralose, and sorbi...

Embodiment 2

[0219] Embodiment 2: Preparation of Famotidine Calcium and Magnesium Chewable Tablets

[0220] Prescription is the same as embodiment 1, and method for making is only different in step (5), promptly respectively changes the time of mixing under relative humidity 85% humid air circulation condition into 0 hour respectively (relative humidity mixes 5 hours less than under the condition of 50%) hour), 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 8 hours, 10 hours, 15 hours, 20 hours, 10 samples were obtained and recorded as Ex21, Ex22, Ex23, Ex24, Ex25, Ex26, Ex27, Ex28, Ex29, Ex20.

[0221] Measure the contact angle and content uniformity of these 10 tablet samples, the result:

[0222] The contact angles of Ex26, Ex27, Ex28, Ex29, Ex20, five tablets whose mixing time is more than 5 hours are all in the range of 46°~83°, and the longer the mixing time, the smaller the contact angle; but Ex21, Ex22 , Ex23, Ex24, and Ex25, the five tablets whose mixing time is less than 5 hours...

Embodiment 3

[0225] Embodiment 3: Preparation of Famotidine Calcium Magnesium Chewable Tablets

[0226] prescription:

[0227] Famotidine 10mg,

[0228] Calcium Carbonate 750mg,

[0229] Magnesium Hydroxide 180mg,

[0230] Sucralose 3mg,

[0231] Sorbitol 70mg,

[0232] Lactose 50mg,

[0233] Starch 200mg,

[0234] Citron Yellow Aluminum Lake 0.2mg,

[0235] Sucrose powder 250mg,

[0236] Peppermint Oil 8mg,

[0237] Povidone K-15 (12% solution) appropriate amount,

[0238] Lemon essence 8mg,

[0239] Magnesium Stearate 20mg.

[0240] Preparation method: carry out with reference to the method of embodiment 1.

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PUM

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Abstract

The invention relates to a famotidine calcium magnesium chewable tablet. The famotidine calcium magnesium chewable tablet contains famotidine, calcium carbonate and magnesium hydroxide. In particular, the invention belongs to the technical field of medicine, and relates to a medicinal composition for treating stomach disease, in particular to a compound medicinal composition of famotidine, calcium carbonate and magnesium hydroxide, in particular to a famotidine calcium magnesium chewable tablet which has superior medicinal property and contains famotidine, calcium carbonate and magnesium hydroxide. The famotidine calcium magnesium chewable tablet has superior pharmaceutical property and superior chemical stability. The famotidine calcium magnesium chewable tablet can be clinically used for treating or preventing acid regurgitation, gastric acid, heartburn (stomach burning), stomachache, stomach distension, belching and other stomach discomfort. A preparation method of the famotidine calcium magnesium chewable tablet is further related.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for treating stomach diseases, in particular to a compound pharmaceutical composition of famotidine (Famotidine), calcium carbonate, and magnesium hydroxide, and more particularly to a compound pharmaceutical composition with Chewable famotidine calcium magnesium tablets containing famotidine, calcium carbonate, and magnesium hydroxide with excellent pharmaceutical properties. The famotidine calcium magnesium chewable tablet of the present invention not only has excellent pharmacy properties, but also has excellent chemical stability. The famotidine calcium magnesium chewable tablet of the present invention can be used clinically for the treatment or prevention of acid reflux, gastric acid, heartburn (heartburn), gastric pain, gastric distension, belching and other stomach discomforts. [0002] Background technique [0003] Stomach disease is a very ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/20A61P1/04A61P1/14A61P1/00A61K31/426
Inventor 张永光熊晓滨逯忠祥柳莉张丽
Owner YANTAI RONGCHANG PHARMA
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