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New pharmaceutical composition for preventing and treating chronic gastritis and alleviating diseases caused by hyperacidity and its preparation method

A technology for hyperacidity and chronic gastritis, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations with non-active ingredients. The effect of reducing adverse reactions

Active Publication Date: 2021-12-28
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the continuous production of gas during the neutralization reaction, users will burp frequently, and the experience of taking medicine is relatively poor; in addition, when patients with hyperacidity symptoms are delayed in seeing a doctor, they are usually accompanied by symptoms of gastric bleeding and gastritis, and the resulting symptoms Stomach pain, stomach cramps and other symptoms

Method used

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  • New pharmaceutical composition for preventing and treating chronic gastritis and alleviating diseases caused by hyperacidity and its preparation method
  • New pharmaceutical composition for preventing and treating chronic gastritis and alleviating diseases caused by hyperacidity and its preparation method
  • New pharmaceutical composition for preventing and treating chronic gastritis and alleviating diseases caused by hyperacidity and its preparation method

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Experimental program
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Effect test

preparation example Construction

[0089] Lubricants can reduce the difficulty of preparation in the product preparation process, such as reducing the adsorption of the active ingredients of the material and the machine, keeping the content not reduced and making the material non-sticky during the tableting process.

[0090] The lubricant is selected from one or more of talc, magnesium stearate, silicon dioxide, fumed silica, and sodium lauryl sulfate; preferably, talc and magnesium stearate are used as lubricants . Compared with other types, the lubricating effect of the lubricant is better, and the amount of the lubricant is less, the lubricant is less difficult to mix with the product material, and it is very easy to mix evenly.

[0091] Preferably, the amount of the lubricant is 10-15 parts by weight; more preferably, in the lubricant, the amount of talc is 7-10 parts by weight; the amount of magnesium stearate is 3-5 parts by weight.

[0092] In the pharmaceutical composition provided by the present inven...

Embodiment 1

[0140] The pharmaceutical composition for preventing and treating chronic gastritis and relieving gastric pain, heartburn and acid regurgitation caused by hyperacidity is prepared according to the following prescription:

[0141] Ingredient name prescription 1 prescription 2 prescription 3 Gastrin 300 280 320 Aluminum hydroxide 70 60 80 Aluminum magnesium carbonate 20 10 30 Muxiang 27 20 45 tangerine peel 20 10 30 Vitamin U 25 15 35 Top eggplant extract 3.3 2.5 4 Licorice Extract 67 60 80 Mannitol 80 70 90 talcum powder 8 7 10 Magnesium stearate 3.5 3 5 95% ethanol 75 70 80

[0142] Among them, the source of gastroin is Chongqing Jiangxia Biochemical Pharmaceutical Co., Ltd.;

[0143] The source of aluminum hydroxide is Shijiazhuang Wuyue Pharmaceutical Factory;

[0144] The source of aluminum magnesium carbonate is Taishan Xinning Pharmaceutical Co., Ltd.;

[0...

experiment example 1

[0167] Acid making power test, the method is as follows:

[0168] Take 20 tablets, grind them finely, weigh about 0.2g, accurately weigh them, put them in a 250ml conical flask with stopper, add 50ml of hydrochloric acid titration solution (0.1mol / L) precisely, seal them tightly, and heat them in a 37°C water bath. For 1 hour, shake it from time to time, let it cool, add 0.5 ml of bromophenol blue indicator solution, and titrate the remaining hydrochloric acid with sodium hydroxide titration solution (0.1 mol / L). Measure the volume of hydrochloric acid titrant (0.1mol / L) consumed by each tablet.

[0169] The sample detection result prepared in embodiment 1 is as follows:

[0170] Example 1 prescription 1 prescription 2 prescription 3 ml / tablet 30.6 26.3 35.2

[0171] In Example 1, the antacids of prescriptions 1-3 were all higher than 30ml / tablet.

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Abstract

The invention provides a new pharmaceutical composition for preventing and treating chronic gastritis and relieving stomach pain, heartburn (heartburn) and acid reflux caused by hyperacidity. It is a compound preparation of Chinese and Western medicines. The main components of the compound preparation include: Aluminum hydroxide, woody incense, licorice extract, belladonna fluid extract; the composition provided by the invention improves the curative effect; the invention also provides a preparation of integrated traditional Chinese and western medicine for chronic gastritis and hyperacidity-induced diseases The method includes a prescription containing traditional Chinese medicine ingredients, an adhesive preparation process, a soft material preparation, a wet granule preparation, and a drying process; the production process is optimized.

Description

technical field [0001] The invention relates to a medicine for treating gastric diseases and a preparation method thereof, in particular to a medicine of integrated traditional Chinese and Western medicine containing traditional Chinese medicine ingredients in western medicine and a preparation method thereof, belonging to the field of integrated traditional Chinese and Western medicine treatment. Background technique [0002] When treating chronic gastritis and relieving stomach pain, heartburn (heartburn), acid regurgitation and other diseases caused by hyperacidity, chemical antacids, such as aluminum magnesium carbonate tablets, are often used for treatment. The main ingredient in chemical antacids reduces hyperacidity by neutralizing reaction with stomach acid, thereby reducing or relieving the symptoms caused by hyperacidity. Due to the continuous production of gas during the neutralization reaction, the user will burp frequently, and the experience of taking the drug ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K47/46A61K47/26A61K38/17A61P1/04A61K31/198A61K36/898A61K33/10A61K33/08
Inventor 傅苗青周白水
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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