8 results about "Gastric hyperacidity" patented technology

The invention is suitable for the technical field of medicine, and provides a stomach medicine capsule and a preparation method thereof, the stomach medicine capsule is prepared from 20-30 parts of Chinese angelica, 7-11 parts of phoenix-tail fern, 15-19 parts of radix berberidis, 5-9 parts of radix aucklandiae, 2-4 parts of reed seed, 13-17 parts of sea snail and auxiliary materials; the preparation method comprises the steps of raw material pretreatment, ethanol reflux extraction, vacuum concentration, spray drying, mixing granulation, capsule filling and packaging. The traditional Chinese medicine raw materials in a specific proportion are screened, the synergistic effect of resisting inflammation and bacteria, regulating qi to relieve pain, nourishing blood and repairing, and relieving acid and protecting the stomach is achieved, and the problems that an existing stomach medicine is single in effect and large in side effect are solved; meanwhile, extraction and drying processes are optimized, the dissolution rate of effective components and the stability of the preparation are improved, and the traditional Chinese medicine composition is suitable for treating stomach diseases such as acute and chronic gastritis, gastric ulcer and hyperacidity, high in safety and suitable for long-term administration.

The invention discloses an application of food-grade sodium carbonate in preparation of a medicine for regulating the acid-base balance of human tissues. The food-grade sodium carbonate conforming to the national food safety standard (GB1886.1) is used as a unique effective component and is dissolved in water to prepare sodium carbonate aqueous solutions with different concentrations, and acid metabolites accumulated in human tissues in local and whole body levels and in human tissues are treated by multiple administration routes such as external use and oral administration. The normal acid-base microenvironment of the tissue is recovered. Wherein the mass concentration of the external preparation is 0.05%-10%, and the mass concentration of the oral preparation is 0.1%-1.5%. The traditional Chinese medicine composition can be used for preventing and / or treating cancers and malignant tumors, stomach diseases related to hyperacidity, femoral head necrosis, muscle strain, frostbite and various diseases taking acid-base imbalance as a common pathological basis. The raw materials are wide in source, low in price and high in safety, the preparation process is simple, the administration scheme is systematic and complete, a single or combined administration route can be flexibly selected according to the specific condition of a patient, and individualized treatment is achieved.

The present disclosure provides diazaspiro compounds represented by Formula (I), processes for their preparation, and pharmaceutical uses thereof, all within the field of medicinal chemistry. The diazaspiro compounds disclosed herein function as small-molecule agonists of the cholecystokinin-B receptor (CCK-BR). They exhibit excellent agonistic potency and demonstrate marked selectivity for CCK-BR over the cholecystokinin-A receptor (CCK-AR), thereby mitigating off-target effects and associated adverse reactions. No cardiotoxicity or other safety liabilities have been observed to date. The diazaspiro compounds are contemplated for the prophylaxis or treatment of disorders including, without limitation, epilepsy, depression, dementia, anxiety, Alzheimer's disease, tinnitus, amblyopia, schizophrenia, neuropathic pain, amnesia, gastric hyperacidity, obesity, pancreatic carcinoma, and gallbladder carcinoma.

This invention provides a traditional Chinese medicine composition for hiccups, acid reflux, and / or bloating, its application, and a drug with the traditional Chinese medicine composition as an active ingredient and its preparation method. The traditional Chinese medicine composition of this invention comprises the following medicinal materials in parts by weight: 3-9 parts agarwood, 3-10 parts processed Evodia rutaecarpa, 10-20 parts cuttlebone, 6-12 parts patchouli, 3-10 parts perilla leaf, 6-12 parts Elsholtzia ciliata, 6-12 parts tangerine peel, 6-10 parts Magnolia officinalis, 6-12 parts Amomum villosum, 6-12 parts stir-fried white hyacinth bean, 6-20 parts stir-fried hawthorn, 3-6 parts Coptis chinensis, 6-12 parts stir-fried malt, 6-15 parts Poria cocos, 3-6 parts licorice root, 6-12 parts talc, 6-15 parts green plum blossom, 3-6 parts cinnamon, and 3-9 parts stir-fried fennel. The traditional Chinese medicine composition of the present invention, when used together, has the combined effects of regulating qi and stomach, relieving nausea and hiccups, neutralizing acid and relieving bloating, strengthening spleen and promoting digestion, and warming the middle and removing dampness. It treats both the symptoms and the root cause, and has a definite and lasting curative effect.

The present invention relates to a composition for alleviating or treating gastrointestinal diseases, the composition comprising a Quercus acuta extract or a fraction thereof. The composition according to the present invention, for preventing, alleviating or treating gastric hyperacidosis, gastric mucosal damage, gastric ulcer, gastritis or gastroesophageal reflux disease, inhibits or restores gastric mucosal damage caused by excessive gastric acid secretion and has excellent gastric protection efficacy, and thus can be safely used without toxicity or side effects.

Omeprazole is used as a widely applied proton pump inhibitor and is mainly used for treating various diseases caused by hyperacidity, such as gastric ulcer, duodenal ulcer, reflux esophagitis and the like. The invention relates to a novel application of a commercially available medicine omeprazole, namely the omeprazole has remarkable anti-aging activity. The research on model organism caenorhabditis elegans finds that omeprazole can significantly prolong the life of nematodes. Specifically, when the nematodes are cultured in culture media containing 1.6 mg / mL omeprazole and 3.2 mg / mL omeprazole, the service lives of the nematodes are prolonged by 47.80% and 61.51% respectively, and the effect is extremely rare in current drug research.

Omeprazole, as a widely used proton pump inhibitor, is mainly used for the treatment of various diseases caused by excessive gastric acid, such as gastric ulcer, duodenal ulcer and reflux esophagitis. The present application relates to a new use of a commercially available drug omeprazole, i.e. it has significant anti-aging activity. The present application found that omeprazole can significantly prolong the life of nematodes through research using model organisms Caenorhabditis elegans. Specifically, when the nematodes are cultured in a medium containing 1.6 mg / mL and 3.2 mg / mL omeprazole, their life is prolonged by 47.80% and 61.51% respectively, which is extremely rare in current drug research.

The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating hypergastric secretion related diseases, a traditional Chinese medicine preparation and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 18 to 22 parts of poria cocos, 10 to 14 parts of rhizoma corydalis, 7 to 11 parts of fructus amomi, 7 to 11 parts of radix aucklandiae, 7 to 11 parts of fructus aurantii, 2 to 6 parts of fructus evodiae, 3 to 7 parts of rhizoma coptidis, 4 to 8 parts of rhizoma zingiberis, 18 to 22 parts of concha arcae, 18 to 20 parts of cuttlebone, 28 to 32 parts of oyster and 18 to 22 parts of malt. Through scientific compatibility of the poria cocos, the rhizoma corydalis, the fructus amomi, the radix aucklandiae, the fructus aurantii, the fructus evodiae, the rhizoma coptidis, the rhizoma zingiberis, the concha arcae, the cuttlebone, the oyster and the malt, the obtained traditional Chinese medicine composition has the effect of inhibiting or treating hyperacidity.