Drop pills for treating diabetes, and preparation method

Abstract

A dripping pill for treating diabetes features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical preparation for treating diabetes made from traditional Chinese medicines. Background technique [0002] A large number of diabetes epidemiological surveys generally show that the prevalence of diabetes in my country is increasing year by year, and the age of onset of non-insulin-dependent diabetes is getting younger. Although the absolute value of diabetes mortality in my country is still at a relatively low level compared with tumors and cardiovascular and cerebrovascular diseases, its rising speed and trend have obviously exceeded those of the above diseases. [0003] Diabetes belongs to the category of diabetes mellitus in the motherland. It is a chronic progressive lifelong disease with long course of disease, complicated pathological changes and many complications. The lesions not only involve the heart, brain, liver, liver, but also...

AI Technical Summary

Problems solved by technology

[0006] Dropping pill preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparation generally faces the following problems: 1. The natural degree of drop pill auxiliary materials is not high: at present, drop pill Pill base excipients are mostly chemical synthetic products with a low degree of naturalness. It is very difficult to find new substitute base excipients, especially the search for alternative base excipients with a high degree of naturalness and the determination of their preparation process, because currently common The preparation conditions required for the possible substitutes of natural matrix excipients are very harsh, and the temperature of the excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent

3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug

4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.

[0007] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production