Lafutidine injecta and its prepn

A lafutidine and injection technology, which is applied in the field of preparations containing lafutidine and its preparation, can solve the difficulty of formula research and processing and preparation, the inability to prepare lafutidine injection, and the lack of marketed preparations for injection, etc. problems, to achieve the effect of improving bioavailability, shortening the time to peak, and taking effect quickly
CN1421204AInactive Publication Date: 2003-06-04ι»„ζŒ―εŽ
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ι»„ζŒ―εŽ
Publication Date
2003-06-04
Estimated Expiration
Not applicable Β· inactive patent
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Abstract

The present invention is Lafutidine injection for intravenous injection and intramuscular injection. The recipe of the Lafutidine injection includes Lafutidine, organic solvent, surfactant, antioxidant, osmotic pressure regulator and water for injection. Compared with Lafutidine tablet, the Lafutidine injection has fast effect, short peak reaching time in the blood high medicine concentration andhigh treating effect; and compared with Famotidine or Ranitidine injection, the Lafutidine injection has less dosage and higher curative effect in treating gastric ulcer.
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Description

Technical field:

[0001] The invention relates to the field of preparation processing, in particular to a preparation containing lafutidine and a preparation method thereof. Background technique:

[0002] The chemical structure of lafutidine is:

[0003] Chemical name: (Β±)-2-(2-furanmethylsulfinyl)-N-{4-[4-(1-piperidylmethyl)-2-pyridyloxy]-cis-2-butene acetamide

[0004] Lafutidine (lafutidine) is a new generation of H 2 Receptor antagonist, mainly used in the treatment of peptic ulcer, this product can reduce the basal secretion of gastric acid, and inhibit the secretion of gastric acid stimulated by histamine, gastrin and urethane. Compared with other similar drugs (such as ranitidine and famotidine), this product is more effective for H 2 The blocking effect of the receptor is more effective and long-lasting, so it has the advantage of a more sustained anti-gastric acid secretion effect. Only lafutidine tablets are currently used clinically, for oral application. ...

Claims

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