Lafutidine injecta and its prepn

Abstract

The present invention is Lafutidine injection for intravenous injection and intramuscular injection. The recipe of the Lafutidine injection includes Lafutidine, organic solvent, surfactant, antioxidant, osmotic pressure regulator and water for injection. Compared with Lafutidine tablet, the Lafutidine injection has fast effect, short peak reaching time in the blood high medicine concentration andhigh treating effect; and compared with Famotidine or Ranitidine injection, the Lafutidine injection has less dosage and higher curative effect in treating gastric ulcer.

Description

Technical field: [0001] The invention relates to the field of preparation processing, in particular to a preparation containing lafutidine and a preparation method thereof. Background technique: [0002] The chemical structure of lafutidine is: [0003] Chemical name: (±)-2-(2-furanmethylsulfinyl)-N-{4-[4-(1-piperidylmethyl)-2-pyridyloxy]-cis-2-butene acetamide [0004] Lafutidine (lafutidine) is a new generation of H 2 Receptor antagonist, mainly used in the treatment of peptic ulcer, this product can reduce the basal secretion of gastric acid, and inhibit the secretion of gastric acid stimulated by histamine, gastrin and urethane. Compared with other similar drugs (such as ranitidine and famotidine), this product is more effective for H 2 The blocking effect of the receptor is more effective and long-lasting, so it has the advantage of a more sustained anti-gastric acid secretion effect. Only lafutidine tablets are currently used clinically, for oral application. ...

AI Technical Summary

Problems solved by technology

At present, its similar drugs ranitidine and famotidine have all developed injection dosage forms, but because the structure of lafutidine is quite different from that of ranitidine and famotidine, its water solubility is extremely poor, almost Insoluble in water, (ranitidine is water-soluble, and famotidine is soluble in weak acids and alcohol solvents), which brings great difficulties to the formulation research and processing preparation of this type of drug injection preparations. Injection processing method can't prepare practical lafutidine injection, so far, there is no bibliographical report that lafutidine is processed into injection preparation successfully, and there is no practical injection preparation listed