Pharmaceutical composition for treating pain syndrome or arthralgia syndrome and preparation method and application thereof
A composition and medicine technology, applied in the field of medicine, to achieve the effect of lasting effect and unique curative effect
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Embodiment 1
[0045] The preparation of embodiment 1 composition rubber ointment of the present invention
[0046] Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, rubber 10Kg, menthol 1.8Kg, borneol 1.2Kg, camphor 1.2Kg, lithopone 25Kg, rosin 6Kg, liquid paraffin 0.5Kg.
[0047] Zedoary Curcumae, Zushima and Sanleng of the prescription amount were taken, pulverized, passed through a 16-mesh sieve, mixed, added 10 times the amount (relative to the quality of the raw material drug) 80% ethanol to extract 3 times, each time for 1h, combined the filtrates, and concentrated into an infusion paste; heat the medicinal material extract through a 100-mesh sieve, and set aside; then cut the rubber into blocks of about 3Kg each, and after the rubber machine operates normally, put the blocks into it and refine them into mesh sheets; melt the rosin, Pass through a 100-mesh steel mesh while it is hot, crush it through a 100-mesh sieve after cooling, and set aside; then mix the prepared rubber flakes, mixed rosin po...
Embodiment 2
[0048] The preparation of embodiment 2 compositions cataplasm of the present invention
[0049] The invention discloses a preparation method of a cataplasm of a pharmaceutical composition for treating pain or arthralgia. It adopts low-temperature production, and a water-soluble polymer substance is used as a matrix, thereby preserving the biological activity of the effective substance without any stimulation to the skin. The addition of a transdermal agent greatly enhances drug release and transdermal properties. It is the latest dosage form of an external plaster. Production methods include:
[0050] Prescription: Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, Menthol 1.8Kg, Borneol 1.2Kg, Gelatin 3Kg, Sodium Polyacrylate 1.5Kg, Polyvinyl Alcohol 1.2Kg, Kaolin 0.5Kg, Glycerin 6Kg, Castor Oil 1Kg, Carboxylic Sodium methylcellulose 1Kg, sorbitol 0.5Kg. Preparation matrix: Take sodium polyacrylate, polyvinyl alcohol, sodium carboxymethyl cellulose, gelatin, sorbitol and add water to s...
Embodiment 3
[0051] The preparation of embodiment 3 compositions ointment of the present invention
[0052] The invention discloses a preparation method of an ointment of a pharmaceutical composition for treating pain or arthralgia. In the method, a semi-solid external preparation is prepared by mixing Chinese medicinal material extracts with a suitable matrix. Production Method:
[0053] Prescription: Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, magnesium sulfate 0.5Kg, dimethyl sulfoxide 0.5Kg, oil-soluble substances 1Kg, water-soluble substances 3Kg (including water 2Kg)
[0054] Zedoary Curcuma, Zushima and Sanleng of the prescribed amount were weighed, pulverized, passed through a 16-mesh sieve, mixed, added 10 times the amount (relative to the quality of the crude drug) 80% ethanol to extract 3 times, each time for 1h, combined filtrates, and concentrated to immersion Ointment, spare. Heat and melt the oil-soluble substance at 80-100°C, dissolve magnesium sulfate, dimethyl sulfoxide, emu...
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