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Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof

A technology of the central nervous system and composition, which is applied in the direction of nervous system diseases, drug combinations, cardiovascular system diseases, etc., and can solve problems such as unseen research

Inactive Publication Date: 2010-10-27
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no literature report on the preparation of preparations made from only the three raw materials of Scutellaria baicalensis, Chuanxiong, and Angelica, especially the combination of these three drugs for the treatment of central nervous system degenerative diseases, and no relevant research has been seen.

Method used

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  • Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof
  • Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof
  • Medicinal composition for treating degenerative change in central nervous system, preparation method and application thereof

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Embodiment 1

[0024] The preparation of embodiment 1 granule of the present invention

[0025] Prescription: Scutellaria baicalensis 150g Chuanxiong 150g Angelica 50g

[0026]Weigh the above-mentioned medicines in the prescribed amount, crush them into coarse powder, combine Angelica and Rhizoma Chuanxiong, add 10 times the weight of water, soak, adopt the method of steam distillation, extract and collect the volatile components obtained, and set aside; filter the water extract, set aside; Combine the filter residue with Scutellaria baicalensis coarse powder, boil and extract 3 times with water, filter, combine the filtrate, combine the obtained filtrate with the water extract of Chuanxiong and Angelica sinensis, concentrate under reduced pressure to obtain a clear paste, and add the obtained volatile components into the clear paste , mix evenly, add starch and microcrystalline cellulose to the clear paste, make soft materials, granulate, dry, and granulate to obtain granules.

Embodiment 2

[0027] The preparation of embodiment 2 tablet of the present invention

[0028] Prescription: Scutellaria baicalensis 150g, Chuanxiong 100g, Angelica sinensis 100g

[0029] Weigh the raw material drug in the prescribed amount, crush it into a coarse powder, combine the raw material medicinal materials, add 20 times the amount of 70% ethanol, soak overnight, wait for the medicinal material to soak, use the percolation method to carry out percolation extraction, collect the percolation extract, Add fresh 70% ethanol to the percolator in good time to supplement, wait until the color of the percolation liquid becomes lighter, and the percolation extraction is completed, combine the collected percolation extracts, concentrate under reduced pressure, and obtain the clear paste of the active ingredient extract of the raw material medicine, which is ready for use Add starch, microcrystalline cellulose, and cross-linked carboxymethyl cellulose to the clear paste of the extract, make so...

Embodiment 3

[0030] The preparation of embodiment 3 capsules of the present invention

[0031] Prescription: Scutellaria baicalensis 200g Chuanxiong 50g Angelica 50g

[0032] Weigh the prescribed amount of raw medicine, crush it into a coarse powder, combine Rhizoma Chuanxiong and Angelica, add 10 times the amount of water to soak until the medicinal materials are saturated, extract and collect the volatile components obtained by steam distillation, and set aside; filter the water extract to obtain the filtrate , the filter residue was extracted twice with water, filtered, each water extract was combined, and concentrated under reduced pressure to obtain clear paste I;

[0033] Scutellaria baicalensis was extracted 3 times with 50% ethanol under reflux, filtered, the filtrate was combined, and the filtrate was concentrated under reduced pressure to obtain Scutellaria baicalensis Extract Clear Cream II;

[0034] Combine clear paste I, II and volatile components evenly, add dextrin and micr...

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Abstract

The invention belongs to the technical field of pharmacy, in particular provides to a medicinal composition, which mainly comprises the following raw material medicaments: baical skullcap root, szechuan lovage rhizome and Chinese angelica. The invention also provides a preparation method and application of the medicinal composition. Through the verification of experiments, the medicinal composition has the effects of detoxifying and removing obstruction in channels and promoting mentality and inducing resuscitation, can improve the cognitive function of dementia or cognitive disorder effectively, improve behavioral anomaly and the life quality of patients and aim at oxidative stress damage in brain cells and micro-inflammatory damage effectively, and has the effect of treating the degenerative change in the central nervous system, particularly senile dementia or vascular dementia or mild cognitive disorder.

Description

technical field [0001] The invention relates to a pharmaceutical composition, which mainly consists of Scutellaria baicalensis, Rhizoma Chuanxiong and Angelica sinensis, and has the effect of treating and alleviating degenerative diseases of the central nervous system, especially treating and alleviating senile dementia, vascular dementia or mild cognitive impairment. The role of cognitive impairment, belongs to the technical field of traditional Chinese medicine. Background technique [0002] Alzheimer's disease is a common degenerative disease of the central nervous system. In recent years, with the aging of the world's population, the incidence of Alzheimer's disease is on the rise. At present, the disease is the fourth cause of death (after heart disease, tumor and stroke), and it has become the current geriatric medicine. One of the most serious problems. According to statistics, the prevalence rate is about 5% in the population over 60 years old in my country, about ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P25/28A61P9/00
Inventor 徐世军辛文锋代渊
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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