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Composition for treating ischemic diseases or neurogenic inflammatory disorders, containing secretome of neural progenitor cells as active ingredient

A technology for neural precursor cells and ischemic diseases, applied in medical preparations containing active ingredients, medical preparations with inactive ingredients, peptide/protein ingredients, etc., can solve problems such as improvement of unknown functions

Pending Publication Date: 2018-04-17
S-BIOMEDICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The differentiation ability of the above-mentioned induced pluripotent stem cells is similar to that of embryonic stem cells, but it is unknown how NPCs differentiated from induced pluripotent stem cells or the culture medium of NPCs contribute to the improvement of post-transplantation function in disease models

Method used

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  • Composition for treating ischemic diseases or neurogenic inflammatory disorders, containing secretome of neural progenitor cells as active ingredient
  • Composition for treating ischemic diseases or neurogenic inflammatory disorders, containing secretome of neural progenitor cells as active ingredient
  • Composition for treating ischemic diseases or neurogenic inflammatory disorders, containing secretome of neural progenitor cells as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0089] Experimental materials and experimental methods

[0090] Obtaining NPC and polysialic acid neural cell adhesion molecule-positive NPC cells derived from human embryonic stem cells or derived from human induced pluripotent stem cells

[0091] The use of human cells was approved by the Institutional Review Board (IRB No. 4-2008-0643). For neural induction, on human embryonic stem cell medium (Invitrogen) without basic fibroblast growth factor, in the presence of 5 μM free base (Sigma, St.Louis, MO) and 5-10 μM SB431542 (Calbiochem, SanDiego, CA) suspension cultured various embryoid bodies (embryoid bodies, EBs) derived from human embryonic stem cells and iPSCs for 4 days, and added 20 ng / ml basic fibroblast growth factor in 1XN2 (Invitrogen) medium for 5 days Left and right were adsorbed on Matrigel-coated Petri dishes (BD Biosciences, Bedford, MA) (Kim, D.S., Lee, D.R., Kim, H.S., et al. (2012). Highly pure and exp andable PSA-NCAM-positive neural precursors from human...

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Abstract

The present invention provides a composition for treating ischemic diseases or neurogenic inflammatory disorders, containing a secretome of neural progenitor cells (NPCs) as an active ingredient. Thesecretome of NPCs, of the present invention, reduces an ischemic injury site and enables neurological functions to recover by means of roles such as anti-inflammation, neovascularization regeneration,and activation and proliferation of inherent stem cells, thereby being usable as a therapeutic agent for ischemic diseases and degenerative nervous system disorders such as nerve damage diseases caused by inflammation. Particularly, the secretome of NPCs, of the present invention, has an excellent behavior improvement effect when administered multiple times.

Description

technical field [0001] The present invention relates to a composition for treating an ischemic disease or a neuroinflammatory disease comprising, as an active ingredient, a secretome of a neural precursor cell (Neural precursor cell; NPC). Background technique [0002] Stem cells are considered as promising therapeutic candidates for various diseases due to their multi-differentiation potential. For example, mesenchymal stem cells (MSCs) have the characteristics of being easily obtained and isolated, promoting angiogenesis, suppressing inflammation, and many nutritional factors (Non-Patent Document 1). These properties of mesenchymal stem cells are applied to the research of treating human diseases. According to recent studies, mesenchymal stem cells play a role in tissue restoration in many animal models and human clinical treatments (Patent Document 2, Patent Document 3). In some reports, the differentiation ability of mesenchymal stem cells into neural series including ...

Claims

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Application Information

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IPC IPC(8): A61K35/30A61K35/545A61K38/17A61K39/395A61K47/36A61K9/00A61K9/10
CPCA61K38/17A61K9/00A61K39/395A61K47/36A61K9/10A61K35/12A61K35/30A61P9/10A61P25/00A61P29/00A61K38/19A61K9/0085A61K9/0019
Inventor 金东旭金汉洙
Owner S-BIOMEDICS CO LTD
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