Core-shell-structured nano-particles modified with 8-aminoquinoline derivative, and preparation method and application thereof

A nanoparticle, core-shell structure technology, applied in nanotechnology, nanotechnology, nanotechnology and other directions for sensing, can solve the problem of long preparation time, inability to obtain the final product of heavy metal ions, and inability to detect divalent zinc ions And other issues

Inactive Publication Date: 2013-07-17
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, both the probe base and its preparation method have shortcomings. First, the probe base can only be used to detect macromolecular substances, as indicated in the instructions, and cannot be used to detect heavy metal io

Method used

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  • Core-shell-structured nano-particles modified with 8-aminoquinoline derivative, and preparation method and application thereof
  • Core-shell-structured nano-particles modified with 8-aminoquinoline derivative, and preparation method and application thereof
  • Core-shell-structured nano-particles modified with 8-aminoquinoline derivative, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The concrete steps of preparation are:

[0032] Step 1, first according to the weight ratio between ferric chloride hexahydrate, sodium acetate and ethylene glycol is 0.8:2.2:30 ratio, iron trichloride hexahydrate and sodium acetate are dissolved in ethylene glycol, and Stir at 45°C until completely dissolved to obtain a precursor solution. Then, the precursor solution was placed in a closed state, and reacted at 200° C. for 8 hours to obtain precipitated iron ferric oxide nanoparticles.

[0033] In step 2, the iron ferric oxide nanoparticles are washed twice with deionized water and ethanol in sequence, and then separated with a magnet. Subsequently, according to the weight ratio between ferric oxide and ethanol of 0.03:5, the iron ferric oxide nanoparticles are dispersed in ethanol to obtain a dispersion liquid. In the dispersion liquid, drip the ammoniacal liquor, deionized water and ethanol that concentration is 26wt% again successively, after mixing uniformly, ob...

Embodiment 2

[0036] The concrete steps of preparation are:

[0037] Step 1, first according to the weight ratio between ferric chloride hexahydrate, sodium acetate and ethylene glycol is the ratio of 0.9:2.1:30, ferric chloride hexahydrate and sodium acetate are dissolved in ethylene glycol, and Stir at 48°C until completely dissolved to obtain a precursor solution. Then, the precursor solution was placed in a closed state, and reacted at 203° C. for 7.5 hours to obtain precipitated iron ferric oxide nanoparticles.

[0038] In step 2, the iron ferric oxide nanoparticles are washed twice with deionized water and ethanol in sequence, and then separated with a magnet. Subsequently, according to the weight ratio between ferric oxide and ethanol of 0.035:5, the nanoparticles of iron ferric oxide are dispersed in ethanol to obtain a dispersion liquid. Then in the dispersion liquid, drip the ammoniacal liquor, deionized water and ethanol that concentration is 27wt% successively, obtain mixed li...

Embodiment 3

[0041] The concrete steps of preparation are:

[0042] Step 1, first according to the weight ratio between ferric chloride hexahydrate, sodium acetate and ethylene glycol is the ratio of 1: 2: 30, ferric chloride hexahydrate and sodium acetate are dissolved in ethylene glycol, and Stir at 50°C until completely dissolved to obtain a precursor solution. Then, the precursor solution was placed in a closed state, and reacted at 205° C. for 7 hours to obtain precipitated iron ferric oxide nanoparticles.

[0043] In step 2, the iron ferric oxide nanoparticles are washed twice with deionized water and ethanol in sequence, and then separated with a magnet. Subsequently, according to the weight ratio between ferric oxide and ethanol of 0.04:5, the nanoparticles of iron ferric oxide are dispersed in ethanol to obtain a dispersion liquid. Then in the dispersion liquid, drip the ammoniacal liquor, deionized water and ethanol that concentration is 28wt% successively, after mixing uniform...

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Abstract

The invention discloses core-shell-structured nano-particles modified with 8-aminoquinoline derivative, and a preparation method and an application thereof. According to the invention, the core-shell-structured nano-particles with iron oxide as cores and silica as shells are modified with the 8-aminoquinoline derivative. The method comprises the steps that: ferric chloride hexahydrate and sodium acetate dissolved in ethylene glycol are placed under a sealed state, and are subjected to a reaction under the temperature of 200-210 DED C, such that a precipitate iron oxide nano-particles are obtained; the nano-particles are dispersed in ethanol; ammonia water, deionized water, ethanol and a tetraethyl orthosilicate ethanol solution are sequentially dropped into the solution; ultrasonic reaction is carried out, and nano-particles are obtained; the nano-particles are sequentially added into toluene, such that a suspension liquid is obtained; N-(quinolin-8-)-2-(3-triethoxysilyl-propylamino)-acetamide is dissolved in toluene, such that a QIOEt toluene solution is obtained; the two are mixed and are subjected to an ultrasonic process; and a reflux reaction is carried out under the temperature of 130-150DEG C, such that a target product is prepared. The product can be widely used for rapidly detecting trace amounts of divalent zinc ions in a solution.

Description

technical field [0001] The invention relates to a nanoparticle, a preparation method and application thereof, in particular to a core-shell structure nanoparticle modified with 8-aminoquinoline derivatives, a preparation method and application thereof. Background technique [0002] As we all know, the magnetic nanoparticle ferroferric oxide has superparamagnetism different from conventional magnetic materials, and it can be separated and recovered by using an external magnetic field. After the external magnetic field disappears, it can restore the high dispersion of the particles; however, it exists The specific surface area or adsorption capacity is small, and the applicable pH range is narrow. Recently, people have made unremitting efforts to overcome the defects of ferric oxide nanoparticles, such as "a 3-methyl- Immunofluorescence PCR detection method of quinoline-2-carboxylic acid". The probe base used in the method for detecting quinoline-containing compounds mention...

Claims

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Application Information

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IPC IPC(8): G01N21/64B82Y15/00B82Y40/00H01F1/11H01F1/36
Inventor 谷瑶孟国文王美玲
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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