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Medicine composition containing budesonide and nitric oxide synthase (NOS) inhibitor and for treating nose inflammation

A composition and nasal administration technology, applied in the field of pharmaceutical compositions, can solve problems such as large irritation and poor compliance, and achieve the effects of alleviating symptoms, inhibiting local immunity reduction, and improving therapeutic effects

Inactive Publication Date: 2013-06-05
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have found that drugs such as S-methylisothiourea and aminoguanidine, due to their own chemical properties, when used in nasal compositions, have greater irritation during treatment, resulting in poor compliance

Method used

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  • Medicine composition containing budesonide and nitric oxide synthase (NOS) inhibitor and for treating nose inflammation
  • Medicine composition containing budesonide and nitric oxide synthase (NOS) inhibitor and for treating nose inflammation
  • Medicine composition containing budesonide and nitric oxide synthase (NOS) inhibitor and for treating nose inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Active ingredient:

[0027] Budesonide 20mg

[0028] L-N 6 -(1-iminoethyl)-lysine 200mg

[0029] Accessories:

[0030] Glycerol 5ml

[0031] Carbomer 934 300mg

[0032] 5% ethylparaben ethanol solution 600μL

[0033] Take the prescribed amount of Carbomer 934 and add glycerin to moisten and grind, add 50ml of purified water to swell as a gel matrix, and add the prescribed amount of L-N 6 -(1-iminoethyl)-lysine, budesonide, 5% ethylparaben ethanol solution, dispersed with 20ml of purified water, slowly added to the gel matrix and stirred evenly, with an appropriate amount of 1mol / L sodium hydroxide to adjust the pH value to 6.0 to 7.0, add purified water to 100ml, budesonide content 0.02%, L-N 6 -(1-iminoethyl)-lysine 0.2%.

Embodiment 2

[0035] The scheme described in embodiment 1, active ingredient is changed into:

[0036] Budesonide 50mg

[0037] N-nitro-L-arginine 250mg

[0038] The dosage of Carbomer 934 was adjusted to 200 mg, other ingredients and preparation method were the same as in Example 1, the prepared pharmaceutical composition was sub-packaged, and the nozzle was installed to obtain the nasal spray gel.

Embodiment 3

[0040] Active ingredient:

[0041] Budesonide 100mg

[0042] N-Monomethyl-L-arginine 200mg

[0043] Accessories:

[0044] Methylparaben 30mg

[0045] Glycerol 5ml

[0046] Take 0.2g of sodium carboxymethyl cellulose, add the prescribed amount of glycerin to 20ml of purified water, stir well and filter, add the prescribed amount of methylparaben into 50ml of purified water, heat to 70°C until completely dissolved, let cool and dissolve the two Parts of the solution are mixed and added with the prescribed amount of active ingredients, stirred evenly, the pH value is adjusted to 5.5 to 7.0, and the remaining water for injection is added. Get nasal drops.

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Abstract

A medicine composition containing budesonide and a nitric oxide synthase (NOS) inhibitor and for treating nose inflammation comprises the budesonide serving as an active constituent, an amino acid derivative serving as the NOS inhibitor, one or more types of medicine auxiliary materials suitable for nose medicine dosing and the balance water.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a nasal pharmaceutical composition containing corticosteroids and NOS inhibitors. Background technique [0002] Budesonide has anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects, and is widely used in the treatment of allergic and autoimmune inflammatory diseases. Such as connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc. It is also used for some serious infections, poisoning, and malignant lymphoma. treat. [0003] Among the existing treatment methods, local glucocorticoids are the first choice for allergic rhinitis. For acute and chronic rhinitis with viral or secondary infection, antiviral or antibiotic treatment is usually used during treatment. In addition, some allergic rhinitis The allergens of rhinitis itself are also microorganisms such a...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/198A61K47/40A61K47/36A61P11/02A61P37/08
Inventor 江薇刘爱
Owner TIANJIN JINYAO GRP
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