Method for wrapping stable retinoid and application
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A retinol and stabilization technology, applied in the field of encapsulating and stabilizing retinoids, can solve the problems of unstable dispersion system, decreased activity, leakage, etc.
Pending Publication Date: 2021-06-08
深圳市护家科技有限公司
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[0005] Liposome is one of the most commonly used encapsulation methods as the carrier of active substances. However, in cosmetics, most of the active substances are encapsulated by liquid liposomes, which ma
Method used
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[0065] Example 1
[0066] Example 1 provides a composition A1 \ b1 \ b2 \ b3 \ b4, which is stabilized from a yellow alcohol
[0067] Retinol stabilizing composition A1 \ B1 \ B2 \ B3 \ B4, respectively in Example 1 and Comparative Examples 1 to 3, each composition shown in the following table (the content of the table percentages are by mass) 1. Preparation of steps of: in the lipid solution in a homogenizer (i.e., (a) ~ (d)) was heated 40 ℃ uniformly mixed, after which stirring was slowly added to the aqueous component contained 40 ℃ active particles uniformly mixed.
[0068] Table 1
[0069]
[0070]
[0071] Stability evaluation
[0072] 1, the appearance evaluation: The prepared stable retinol composition A1 \ B1 \ B2 \ B3 \ B4 placed in front of a white background plate, the composition is visually observed whether or emulsion, if aggregated particles or distinct layers referred For x, if it is a kind of cream, if it is a lotus, it is ο.
[0073] 2, room temperature st...
Example Embodiment
[0077] Example 2
[0078] Example 2 provides a composition A2 that stabilizes the yellow alcohol
[0079] Stable composition A2 of the yellow alcohol, its composition is shown in Table 1 (the content in the table is percentage), the preparation step is: lipid solution (ie (a) ~ (d)) in a homogeneous machine The heating was mixed at 40 ° C for mixing, and then slowly added to the aqueous component of the active particles containing the active particles at 40 ° C.
[0083] 1, skin keratin layer water content Corneometer value test
[0084] 1) Test Instrument: Instrument Skin Moisture Tester CORNEMETER CM825
[0085] 2) Test Principle: The test pr...
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Abstract
The invention relates to the technical field of liposome wrapping, in particular to a method for wrapping stable retinoid and application. The method for wrapping stable retinoid is characterized in that a lipid solution is provided, retinoid is added into the lipid solution, the lipid solution is oscillated, and the lipid solution at least comprises (a) 0.1-10% of ester with the IOB value of 0.2-0.6 and (b) 8-30% of water-soluble polymer on the basis of the total mass of the lipid solution. According to the method for wrapping the stable retinoid, a dual-vitamin A or multi-vitamin A anti-aging system is utilized, and a liposome coating process is matched, so that the transdermal absorption rate of active ingredients is remarkably improved, and the effects of deep oxidation resistance and aging resistance are achieved, meanwhile, the problems of poor stability and large irritation of active particles are solved by utilizing the combination of special components in the lipid solution, and the self-control slow release of the active components is also realized, so that the utilization rate of the active components is improved.
Description
technical field [0001] The invention relates to the technical field of liposome encapsulation, in particular to a method and application of encapsulating and stabilizing retinoids. Background technique [0002] Aging is a stage that must be experienced in any biological life process. It is the gradual decline of morphological structure and physiological function caused by the influence of genetic factors and external environment (light, radiation, pollution, etc.) process. Human beings are also bound to experience aging, and of course, as the largest organ of the human body-skin is also bound to experience aging (aging). [0003] Retinoid products currently on the market are widely used in the field of cosmetics because of their anti-aging effects. Alcohols and retinyl esters (eg, retinyl acetate, retinyl propionate, retinyl palmitate, and retinyl linoleate) and the like. [0004] Since retinoids are sensitive to light, oxygen, temperature, and metal ions, and are more li...
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