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Method for wrapping stable retinoid and application

A retinol and stabilization technology, applied in the field of encapsulating and stabilizing retinoids, can solve the problems of unstable dispersion system, decreased activity, leakage, etc.

Pending Publication Date: 2021-06-08
深圳市护家科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Liposome is one of the most commonly used encapsulation methods as the carrier of active substances. However, in cosmetics, most of the active substances are encapsulated by liquid liposomes, which may cause the instability of the dispersion system: such as the penetration of active substances. Leakage, aggregation of particles, etc., which affect the stability of liposomes, resulting in reduced activity

Method used

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  • Method for wrapping stable retinoid and application
  • Method for wrapping stable retinoid and application
  • Method for wrapping stable retinoid and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 provides the composition A1\B1\B2\B3\B4 of stabilizing retinol

[0067] Compositions A1\B1\B2\B3\B4 for stabilizing retinol correspond to Example 1 and Comparative Examples 1 to 3 respectively, and their respective components are shown in Table 1 below (the contents in the table are all in mass percentage), prepared The steps are: heat the lipid solution (i.e. (a) to (d)) in a homogenizer at 40°C and mix evenly, and then slowly add it to the water-based component containing active particles at 40°C, stir and mix evenly.

[0068] Table 1

[0069]

[0070]

[0071] Stability Evaluation

[0072] 1. Appearance evaluation: Place the prepared stable retinol composition A1\B1\B2\B3\B4 in front of a white background board, and visually observe whether the composition is in the form of an emulsion. If there is obvious layering or particle aggregation It is X, if it is creamy, it is marked as △, if it is emulsion, it is marked as O.

[0073] 2. Stability e...

Embodiment 2

[0078] Example 2 provides composition A2 for stabilizing retinol

[0079] Composition A2 for stabilizing retinol, its ingredients are shown in Table 1 below (the contents in the table are all in mass percentage), the preparation steps are: in a homogenizer, the lipid solution (ie (a)~(d)) Heat at 40°C and mix uniformly, then slowly add it to the water-based component containing active particles at 40°C and stir to mix uniformly.

[0080] table 3

[0081] components Percent content Composition for stabilizing retinol (A1) 5％ behenic acid 8.6％ behenyl alcohol 5.1％ Hexametaphosphate 0.1％ p-Hydroxyacetophenone 0.05％ carbomer 3.5％ Polydimethylsiloxane 2.3％ hydroxyphenylpropanamide benzoic acid 0.5％ water To100

[0082] Efficacy performance evaluation

[0083] 1. Corneometer value test of skin stratum corneum water content

[0084] 1) Test instrument: instrument skin moisture tester Corneometer CM825

[008...

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Abstract

The invention relates to the technical field of liposome wrapping, in particular to a method for wrapping stable retinoid and application. The method for wrapping stable retinoid is characterized in that a lipid solution is provided, retinoid is added into the lipid solution, the lipid solution is oscillated, and the lipid solution at least comprises (a) 0.1-10% of ester with the IOB value of 0.2-0.6 and (b) 8-30% of water-soluble polymer on the basis of the total mass of the lipid solution. According to the method for wrapping the stable retinoid, a dual-vitamin A or multi-vitamin A anti-aging system is utilized, and a liposome coating process is matched, so that the transdermal absorption rate of active ingredients is remarkably improved, and the effects of deep oxidation resistance and aging resistance are achieved, meanwhile, the problems of poor stability and large irritation of active particles are solved by utilizing the combination of special components in the lipid solution, and the self-control slow release of the active components is also realized, so that the utilization rate of the active components is improved.

Description

technical field [0001] The invention relates to the technical field of liposome encapsulation, in particular to a method and application of encapsulating and stabilizing retinoids. Background technique [0002] Aging is a stage that must be experienced in any biological life process. It is the gradual decline of morphological structure and physiological function caused by the influence of genetic factors and external environment (light, radiation, pollution, etc.) process. Human beings are also bound to experience aging, and of course, as the largest organ of the human body-skin is also bound to experience aging (aging). [0003] Retinoid products currently on the market are widely used in the field of cosmetics because of their anti-aging effects. Alcohols and retinyl esters (eg, retinyl acetate, retinyl propionate, retinyl palmitate, and retinyl linoleate) and the like. [0004] Since retinoids are sensitive to light, oxygen, temperature, and metal ions, and are more li...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/68A61K8/14A61Q19/08
CPCA61K8/671A61K8/68A61K8/14A61Q19/08A61K2800/56
Inventor 姚哲男舒鹏
Owner 深圳市护家科技有限公司
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