111 results about "Cerebral palsied" patented technology

The invention discloses a magnetic resonance method for evaluating the rehabilitation curative effect of child cerebral palsy, and relates to the technical field of medical image processing. The method comprises: obtaining structural image data (T1 weighted imaging and diffusion tensor imaging) and resting state image data of each child patient; and extracting brain and tissue boundaries from the T1 weighted imaging by using a 3D-Unet segmentation model. The resting state and structure image data are preprocessed and aligned to the brain boundary, and then the data are registered to a child standard brain template; based on a child standard brain template, obtaining and normalizing various clinical indexes, splicing the clinical indexes into multi-index vector data, inputting the multi-index vector data into a pre-trained support vector machine model, and outputting clinical index differences; and determining an abnormal brain region of each child according to the difference, finally providing a multi-modal fusion index analysis report, and observing changes of brain functions and white matter integrity before and after rehabilitation.

The invention belongs to the technical field of artificial intelligence, and discloses a cerebral palsy child multi-mode rehabilitation training system based on artificial intelligence. The system comprises a data acquisition and preprocessing module, a multi-modal information fusion module, a personalized rehabilitation training suggestion generation module, an interaction and excitation module, a progress tracking and abnormity early warning module, a doctor and parent end APP management module and a system control and management module. According to the invention, when the interaction and excitation module and the multi-modal information fusion module are combined and applied to rehabilitation training of children with cerebral palsy, the training effect can be significantly improved, and accurate evaluation and personalized training can be realized; the child patient can be trained in a more real and attractive environment, meanwhile, the enthusiasm of the child patient is further stimulated through the gamification excitation design, and the training motivation of the child patient is enhanced through real-time feedback encouragement.

The invention discloses a video-based 3D cerebral palsy baby action recognition method and system, and is applied to the technical field of baby action recognition. The method specifically comprises the following steps: respectively acquiring video files of normal twisting motion and abnormal monotonous motion of an infant, performing frame extraction processing to obtain image data of the infant, labeling the image data of the infant, making a data set based on the labeled image data of the infant, constructing and training a key point recognition model and a motion recognition model, and performing image recognition on the key point recognition model and the motion recognition model. And performing infant action recognition through the trained key point recognition model and action recognition model. According to the method, the data set containing the normal twisting motion and the abnormal monotonous motion image of the infant is made, the key point recognition model and the motion recognition model for recognizing the motion of the infant are constructed and trained, the motion posture can be rapidly and accurately extracted based on the monitoring video data of the infant, and support is provided for assessment of the infant with cerebral palsy.

The present invention relates generally to compositions and methods useful for treating brain injuries such as stroke, optic neuropathy, traumatic brain injury, and cerebral palsy. The methods comprise administering to a subject HMC obtained by in vitro differentiation of pluripotent stem cells and / or extracellular vesicles (EV) derived from these HMCs (HMC-EV).

The invention belongs to the technical field of computer vision, and discloses an arm movement automatic evaluation system and method for dyskinesia of a cerebral palsy patient, and the system is characterized in that a data collection module carries out the movement data collection of the movement task of the arm of the patient through a smart phone camera; the posture estimation and key point detection module uses a posture estimation algorithm to automatically detect and track arm movement of a patient and recognize key points of a human body, and after coordinate data of the key points are obtained, data preprocessing is carried out; the muscular dyskinesia feature extraction module extracts muscular dyskinesia features from the motion data of the arm of the patient and constructs a corresponding feature set; the automatic scoring module uses a multi-layer feedforward neural network model to automatically calculate the score of the muscular dystonia based on the arm movement characteristics of the patient; the report generation module is used for generating an evaluation report. The method is suitable for arm movement evaluation of myodynia of cerebral palsy patients, and an objective, convenient and efficient evaluation tool is provided for clinicians.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

To provide 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase.SOLUTION: Disclosed are 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase (NOS). In particular, the field of the present invention relates to 2-aminopyridine derivative compounds for use as inhibitors of neuronal nitric oxide synthase (nNOS), which are formulated as pharmaceutical compositions for treating nNOS-associated diseases and disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as amyotrophic lateral sclerosis, cerebral palsy, stroke / ischemic brain injury, and migraine headaches.SELECTED DRAWING: Figure 1

The present invention generally relates to compositions and methods useful for treating a brain injury such as stroke, optic neuropathy, traumatic brain injury, and cerebral palsy. The methods include administering HMCs obtained by in vitro differentiation of pluripotent stem cells and / or extracellular vesicles (EVs) derived from such HMCs (HMC-EVs) into a subject.

The invention discloses a multi-modal sensing data automatic labeling method and system for gait assessment, and the system comprises a sensing collection module which comprises two paths of pressure sensors and a six-axis IMU sensor; the two paths of pressure sensors are used for acquiring plantar pressure data; the six-axis IMU sensor is used for acquiring lower limb movement data; the wireless transmission module is used for uploading the collected plantar pressure data and lower limb movement data to a cloud Internet of Things platform; the cloud data processing module is used for receiving and storing the plantar pressure data and the lower limb movement data; the data labeling module is used for automatically recognizing a gait cycle and carrying out multi-dimensional score labeling; and the user interaction module is used for interacting with the data annotation module and the cloud data processing module and displaying gait evaluation related data and results. According to the invention, a multi-mode sensing PCB is self-developed, a closed-loop system of collection, cloud loading, labeling and display is constructed, and accurate, continuous and remote evaluation of gaits of children with cerebral palsy is realized.

The present invention relates to the technical field of data compression, and particularly to a method for monitoring rehabilitation exercise information of cerebral palsy patients based on wearable devices; obtaining a motion state according to the distribution characteristics of heart rate data; obtaining an acceleration similarity according to the types of acceleration data; obtaining heart rate outliers and normal heart rate points according to the acceleration similarity; obtaining a first acceleration discrete point and an acceleration continuous point according to the heart rate outliers. Obtaining an acceleration cross-region point and a second acceleration discrete point according to the differential characteristics of the acceleration similarity; determining a corresponding motion state according to the acceleration cross-region point; obtaining an acceleration anomaly point according to the first acceleration discrete point and the second acceleration discrete point. The present invention adaptively compresses acceleration data according to the distribution characteristics of acceleration data corresponding to acceleration anomaly points and normal heart rate points, improving the compression efficiency and transmission real-time performance.

The invention discloses a horse psychological soothing training method, which comprises the following steps of: preliminary evaluation: before treatment is started, comprehensively evaluating the physical condition, the athletic ability, the cognitive level and the emotional state of a child by a professional equestrian therapist and a rehabilitation doctor; at the stage, the dyskinesia type, muscle tension, joint flexibility, balance ability and emotion requirements of the child need to be recorded in detail, and a treatment target is set: the treatment target is determined according to an evaluation result. Through equestrian treatment, children with cerebral palsy can be improved in multiple aspects of body, cognition and emotion. In the horse riding process, the balance, coordination, strength and other body abilities of children can be enhanced, and the children can be helped to improve confidence, social skills and emotion control. The equestrian treatment is a unique rehabilitation method, a natural and warm relation is established through interaction with horses, and comprehensive rehabilitation support can be provided for children with cerebral palsy.

The invention discloses a sitting posture correction chair for cerebral palsy children, and relates to the technical field of sitting posture correction chairs. The sitting posture correcting chair comprises a sitting posture correcting chair body, the sitting posture correcting chair body comprises a bearing structure, a supporting structure, a lifting structure and a placing structure, the supporting structure is arranged above the bearing structure, the lifting structure and the placing structure are arranged below the bearing structure, the supporting structure comprises a supporting frame, and the supporting frame is arranged above the lifting structure. An arm placing plate is arranged between the supporting frames in a sliding mode, sliding blocks are fixedly arranged on the two sides of the arm placing plate, the sliding blocks are arranged in the supporting frames in a sliding mode, a transverse plate is arranged in the sliding blocks in a sliding mode, a pull rod is fixedly arranged on the bottom face of the transverse plate, and the sliding blocks are driven by the arm placing plate to slide in sliding grooves, so that the arm placing plate can be adjusted; then the positioning rods are inserted into the positioning grooves, so that the internal space of the sitting posture correction chair body can be changed, the sitting posture correction chair is suitable for child patients of different ages, and the applicability of the sitting posture correction chair body is improved.

The invention relates to the technical field of cerebral palsy language education, and discloses a cerebral palsy language slow intervention-oriented situational interactive teaching tool, which comprises a situational interaction module used for constructing a virtual scene and realizing language training through a multi-modal interaction technology; the personalized adaptation module is used for carrying out personalized adjustment on the interaction mode and the difficulty level in the situation interaction module according to the physical condition and the language ability evaluation result of the user; the reward and feedback module is used for monitoring operation and performance of the user in real time and giving corresponding rewards according to a preset rule; the user management module is used for storing personal information, training records and evaluation data of the user; and an intelligent analysis module. By means of the voice, gesture and eye movement multi-mode interaction technology, a natural interaction mode matched with the physical condition of a patient is constructed, language training is stimulated in an all-round mode in a scene contact interaction mode, the language expression and communication ability of the patient is remarkably improved, and the training enthusiasm is enhanced.

This invention relates to a method for continuous motion prediction in patients with cerebral palsy. The method includes: acquiring sEMG data, IMU data, and ground truth joint angles of the subjects and constructing a dataset; dividing the dataset into training, validation, and test sets for each subject according to time sequence; standardizing the collected EMG and IMU data for each subject to obtain standardized sequence data; inputting the standardized sequence data of each subject into a trained prediction network, which includes parallel TCN and GAT modules. The TCN module extracts IMU temporal features, and the GAT module extracts sEMG spatial features. The two types of features are fused through a multimodal fusion module and then input into a BiLSTM network for bidirectional temporal modeling to capture the bidirectional temporal dependence of movements. Finally, a regression output module outputs the standardized predicted angles. Compared with existing technologies, this invention has advantages such as achieving continuous and accurate motion prediction for patients with cerebral palsy and enhancing cross-subject generalization ability.

The walking assisting device for the cerebral palsy children comprises a bottom frame, two grab rails and a supporting plate, the bottom frame is provided with a standing space suitable for a user to stand, and the rear portion of the standing space is open to form an access for the user to go in and out; the two grab rails are arranged on the left side and the right side of the bottom frame respectively, and each grab rail extends in the vertical direction. The supporting plate is horizontally arranged between the two grab rails, one end of the supporting plate is connected with one of the two grab rails, the other end of the supporting plate is connected with the other one of the two grab rails, and the supporting plate can slide in the vertical direction and can be selectively locked and fixed to different height positions. The walking assisting device for the children with cerebral palsy integrally forms a support design similar to a semi-enclosed support, has good stability and supporting performance, and can effectively assist the children with cerebral palsy in walking.

The invention provides a wheelchair suitable for children with cerebral palsy, and relates to the technical field of wheelchairs, according to the wheelchair, a physiotherapy cushion is mounted on a wheelchair body seat through a first connecting belt, and the lower end of a first sitting posture correction assembly is connected with the position, close to the front end, of the physiotherapy cushion through a second connecting belt; the two sides of the first sitting posture correcting assembly are installed by bypassing a backrest of the wheelchair body through third connecting belts, so that the chest of the child patient is tightly attached to the first sitting posture correcting assembly, the back of the child patient is tightly attached to the backrest of the wheelchair body, and the situation that the body of the child patient inclines forwards is reduced; the second sitting posture correction assembly is installed on the wheelchair body and used for restraining the two sides of the body of the child patient, and the situation that the body of the child patient inclines leftwards and rightwards is reduced; the hand restraining exercise assembly is installed on the first sitting posture correction assembly and used for restraining the hands of the child patient so as to reduce the phenomenon that the hands of the child patient are scratched. According to the scheme, the effect of correcting the sitting posture and the hand carving behavior of the cerebral palsy child can be improved, and rehabilitation training of the child patient is promoted.

The invention provides a neurology data analysis method and device and a medium, and relates to a data analysis technology. A database is constructed by combining data of a plurality of cerebral palsy patients, and medical images such as CT images and symptom description data of the patients are collected; therefore, the pathological part of the current patient can be predicted in combination with the data in the database and the comparison result of the image data acquired by the acquisition device for the current patient, and the display image is generated to display the predicted illness state for the patient, so that doctors can be assisted in diagnosis, and more suitable diagnosis and treatment suggestions are provided for the patient.

The present invention relates to a protein for the prevention or treatment of neurological diseases and a pharmaceutical composition containing the same. According to one aspect, the protein or polynucleotide exhibits excellent therapeutic effects in animal models of stroke, cerebral palsy, dementia, Parkinson's disease, and autism, and thus has the effect of being useful for the prevention or treatment of neurological diseases that are difficult to regenerate.

The invention discloses a lower limb rehabilitation device and method for children with cerebral palsy, and relates to the technical field of medical treatment. Comprising a seat and a pedal mechanism arranged at the front end of the seat, the pedal mechanism comprises a permanent magnet motor, a first pedal and a second pedal, and the first pedal and the second pedal are correspondingly arranged on the two sides of the permanent magnet motor; the system further comprises a host, VR glasses, an upper computer, a permanent magnet motor driver and a detection unit of a pedal mechanism. The detection unit is arranged on the pedal mechanism and is in communication connection with the host; the VR glasses and the upper computer are in communication connection with the host; and the permanent magnet motor driver is arranged on the permanent magnet motor and is connected with the upper computer. Games presented by the VR glasses add fun to rehabilitation, multi-sensory stimulation of the VR glasses promotes plasticity of brain nerves, training time can be effectively prolonged, training frequency and intensity can be improved, a new way is developed for rehabilitation treatment of children with cerebral palsy, and the rehabilitation process of the children with cerebral palsy is powerfully promoted; the structure is simple and easy to realize, and the experience of cerebral palsy children is improved.

The method is mainly applied to the technical field of brain-computer interface and time sequence signal analysis. The invention discloses a brain signal processing method, system and device for assisting a cerebral palsy patient in movement and a medium. The method comprises the steps that a first electroencephalogram signal and a second electroencephalogram signal are obtained; generating a first instruction set according to the first electroencephalogram signal, and generating a second instruction set according to the second electroencephalogram signal; adjusting the second instruction set by taking the first instruction set as a target to obtain the adjusted second instruction set and taking the adjusted second instruction set as a target instruction set; and according to the target instruction set, controlling preset auxiliary equipment, so that the user completes the motion action through the preset auxiliary equipment. The brain signal of the cerebral palsy patient can be adjusted, the cerebral palsy patient is assisted in completing movement actions, and therefore the movement function of the cerebral palsy patient can be improved.

Disclosed are compounds of formula (I) wherein G1 is as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in the treatment of e.g. a neurodegenerative disorder, a movement disorder, or a brain disorder, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. (2,5-difluoro-4-(6-(((3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-λ6-sulfanone (e.g. example 12; compound no. 7) Pharmacological data on the activity of the compounds in an mAChR M4 cell-based assay are provided (e.g. table 2).TABLE 2Human M4Cpd. No.IC50 (nM)Emin (%)*113.44239.62318.5345846575.4361883746.0385607918.43101.821186.231243.42138.63*% ACh maximum at 30 μM.

This invention discloses a game-interactive fine motor training device for children with cerebral palsy, relating to the field of cerebral palsy motor training. An audio-visual interactive button is nested inside a preset base, and a first return spring is fixedly connected to the lower end of the button, with the first return spring engaging with the inner side of the preset base. A fixed top rod is fixedly connected to the inner side of the preset base, extending along the inner side of the interactive button. A guide support structure is provided on the inner side of the interactive button. This game-interactive fine motor training device for children with cerebral palsy includes a guide support structure that prompts the user whether the pressure applied is appropriate. Once the pressure is sufficient, the user can release the button, simulating fine motor operations in daily life, such as single-finger clicking or alternating pressing. The child can then determine whether their pressure application is adequate.

The invention discloses a limb posture correcting device for a child cerebral palsy patient and a using method of the limb posture correcting device. The limb posture correcting device comprises a base, a seat is installed on one side of the upper end of the base, a cushion is installed at the upper end of the seat, a back cushion is installed on one side wall of the seat, and a pedal is arranged on one side of the seat. The limb posture correcting device has the beneficial effects that through the design of the base, the seat, the supporting column, the sliding base, the first electric sliding rail, a carrying plate, an electric push rod, a correcting plate, a rotating shaft and a rotating motor, the limb posture correcting device can replace medical staff to conduct electric control on the limb posture of a child cerebral palsy patient to conduct straightening operation, and therefore the workload of the medical staff is reduced; meanwhile, the working efficiency is improved, through the design of a pedal, a non-slip mat, a driving motor, a rotating shaft, a correcting block, a grab handle, a sliding block and a second electric sliding rail, the limb posture correcting device can provide the posture correcting function for the limbs of the patient, and the application range of the correcting device can be wider.

The present invention relates to a protein for the prevention or treatment of neurological diseases and a pharmaceutical composition containing the same. According to one aspect, the protein or polynucleotide exhibits excellent therapeutic effects in animal models of stroke, cerebral palsy, dementia, Parkinson's disease, and autism, and thus has the effect of being useful for the prevention or treatment of neurological diseases that are difficult to regenerate.

The application provides an electromyogram muscle strength prediction method suitable for hand function rehabilitation training of children with cerebral palsy, and specifically comprises the following steps: constructing a muscle strength prediction source domain network model, and using an electromyogram muscle strength database to train and test the model; proposing a gesture set and a synchronous acquisition scheme of electromyogram signals and muscle strength signals of each gesture according to the rehabilitation training requirements of children with cerebral palsy; collecting electromyogram and muscle strength data generated when healthy children perform each gesture action, optimizing the muscle strength prediction source domain network model by using a transfer learning method, and obtaining a specific muscle strength prediction model for each gesture; collecting electromyogram signals and muscle strength signals of children with cerebral palsy during rehabilitation training of different gestures, realizing muscle strength prediction by using the specific muscle strength prediction model, and evaluating the completion effect of rehabilitation gestures of children with cerebral palsy according to the error between the predicted value and the actual value. The method is conducive to formulating a specific rehabilitation scheme and evaluating the rehabilitation treatment effect by clinicians, and better promotes the rehabilitation treatment of children with cerebral palsy.

The utility model provides a head and neck flexible supporting device for rehabilitation of children with cerebral palsy, which belongs to the technical field of medical auxiliary instruments and comprises a plurality of elastic air bags. The elastic air bags are connected in a sleeved mode and limited in the sleeve lock, and the multiple elastic air bags are sequentially stacked in the vertical direction; the two ends of the telescopic connecting piece are connected with the two ends of the elastic air bag respectively, and the telescopic connecting piece is used for driving the elastic air bag to be bent in an arc mode so as to drive the two ends of the elastic air bag to be close to or away from each other. The elastic air bags are soft and elastic, in the process of supporting the head and the neck of a child patient, the hard object supporting feeling is avoided, the wearing comfort level is improved, and the neck of the child patient is sleeved with the annular elastic air bag defined by the multiple elastic air bags which are sequentially stacked, so that the neck of the child patient is more comfortable to wear. The multiple elastic air bags stacked in sequence can adapt to child patients with different neck lengths, the necks of the child patients are kept in a vertical state, and the necks of the child patients are prevented from drooping.

Methods and systems to reduce symptoms of cerebral palsy in children are disclosed herein. In one embodiment, a method for alleviating spasticity of a lower extremity caused by a brain injury includes attaching at least one electrode on a surface of patient's skin, proximate to patient's spinal cord. The method also includes subjecting the patient to a regimen of training that improves walking of the patient; applying a series of pulses to the at least one electrode while the patient is in training; and in response to applying the series of pulses to the at least one electrode, inducing stimulation in the spinal cord that alleviates spasticity of the lower extremity.

The invention discloses an arm exercise device for child rehabilitation, which comprises a base and a protective plate arranged on the base and used for supporting the arm part of a child, the protective plate comprises an upper arm supporting arc plate and a forearm supporting protective plate which are respectively used for fixing the upper arm and the forearm of the arm, and the base is provided with a swing structure for driving the arm of the child to perform bending training. The swing structure comprises a position stopping sliding block arranged on the base, a left vertical frame and a right vertical frame which swing synchronously are arranged on the position stopping sliding block, and an arm swing assembly for driving the upper arm supporting arc plate and the front arm supporting protection plate to swing synchronously in the vertical direction in a reciprocating mode is arranged on the base. The requirement of the cerebral palsy children for the arm movement range in different life scenes is met, so that the arm function is more comprehensively improved, and the daily life self-care ability of the children is improved through diversified bending amplitude training.

1. Name of the designed product: walking aid (for children with cerebral palsy). 2. Use of the designed product: for walking aid for children with cerebral palsy. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

The utility model provides a protective garment worn by a cerebral infarction paralyzed patient in a wheelchair, the upper part of the protective garment is a back cardigan type round collar vest, the outer sides of the left shoulder and the right shoulder of the vest are respectively sewn with a longitudinal drawstring, the lower hem of the front piece of the vest is fixedly connected with a front crotch separation blade, and the lowermost end of the front crotch separation blade is sewn with a transverse bandage; a replaceable saliva blocking towel is hung at the chest position of the front side of the front piece of the vest, the saliva blocking towel is clamped and fixed through an elastic opening of an arc-shaped shallow bag on the vest, a replaceable knee shielding blocking towel is hung on the front side of the front crotch blocking piece, and the knee shielding blocking towel is clamped and fixed through a transverse shallow bag on the vest. According to the protective clothing, the shoulders of a wheelchair patient can lean against, the upper body of the wheelchair patient can be prevented from bending forwards, the buttocks of the patient can be limited, the body of the patient can be prevented from sliding downwards, and the sitting posture of the patient can be prevented from inclining, so that the body of the patient can be kept in a normal functional position; and clothes and trousers of the patient are prevented from being polluted by saliva and fallen food.