88 results about "Cerebral palsied" patented technology

The invention belongs to the technical field of artificial intelligence, and discloses a cerebral palsy child multi-mode rehabilitation training system based on artificial intelligence. The system comprises a data acquisition and preprocessing module, a multi-modal information fusion module, a personalized rehabilitation training suggestion generation module, an interaction and excitation module, a progress tracking and abnormity early warning module, a doctor and parent end APP management module and a system control and management module. According to the invention, when the interaction and excitation module and the multi-modal information fusion module are combined and applied to rehabilitation training of children with cerebral palsy, the training effect can be significantly improved, and accurate evaluation and personalized training can be realized; the child patient can be trained in a more real and attractive environment, meanwhile, the enthusiasm of the child patient is further stimulated through the gamification excitation design, and the training motivation of the child patient is enhanced through real-time feedback encouragement.

The invention discloses a video-based 3D cerebral palsy baby action recognition method and system, and is applied to the technical field of baby action recognition. The method specifically comprises the following steps: respectively acquiring video files of normal twisting motion and abnormal monotonous motion of an infant, performing frame extraction processing to obtain image data of the infant, labeling the image data of the infant, making a data set based on the labeled image data of the infant, constructing and training a key point recognition model and a motion recognition model, and performing image recognition on the key point recognition model and the motion recognition model. And performing infant action recognition through the trained key point recognition model and action recognition model. According to the method, the data set containing the normal twisting motion and the abnormal monotonous motion image of the infant is made, the key point recognition model and the motion recognition model for recognizing the motion of the infant are constructed and trained, the motion posture can be rapidly and accurately extracted based on the monitoring video data of the infant, and support is provided for assessment of the infant with cerebral palsy.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

To provide 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase.SOLUTION: Disclosed are 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase (NOS). In particular, the field of the present invention relates to 2-aminopyridine derivative compounds for use as inhibitors of neuronal nitric oxide synthase (nNOS), which are formulated as pharmaceutical compositions for treating nNOS-associated diseases and disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as amyotrophic lateral sclerosis, cerebral palsy, stroke / ischemic brain injury, and migraine headaches.SELECTED DRAWING: Figure 1

The present invention generally relates to compositions and methods useful for treating a brain injury such as stroke, optic neuropathy, traumatic brain injury, and cerebral palsy. The methods include administering HMCs obtained by in vitro differentiation of pluripotent stem cells and / or extracellular vesicles (EVs) derived from such HMCs (HMC-EVs) into a subject.

The invention discloses a multi-modal sensing data automatic labeling method and system for gait assessment, and the system comprises a sensing collection module which comprises two paths of pressure sensors and a six-axis IMU sensor; the two paths of pressure sensors are used for acquiring plantar pressure data; the six-axis IMU sensor is used for acquiring lower limb movement data; the wireless transmission module is used for uploading the collected plantar pressure data and lower limb movement data to a cloud Internet of Things platform; the cloud data processing module is used for receiving and storing the plantar pressure data and the lower limb movement data; the data labeling module is used for automatically recognizing a gait cycle and carrying out multi-dimensional score labeling; and the user interaction module is used for interacting with the data annotation module and the cloud data processing module and displaying gait evaluation related data and results. According to the invention, a multi-mode sensing PCB is self-developed, a closed-loop system of collection, cloud loading, labeling and display is constructed, and accurate, continuous and remote evaluation of gaits of children with cerebral palsy is realized.

The present invention relates to the technical field of data compression, and particularly to a method for monitoring rehabilitation exercise information of cerebral palsy patients based on wearable devices; obtaining a motion state according to the distribution characteristics of heart rate data; obtaining an acceleration similarity according to the types of acceleration data; obtaining heart rate outliers and normal heart rate points according to the acceleration similarity; obtaining a first acceleration discrete point and an acceleration continuous point according to the heart rate outliers. Obtaining an acceleration cross-region point and a second acceleration discrete point according to the differential characteristics of the acceleration similarity; determining a corresponding motion state according to the acceleration cross-region point; obtaining an acceleration anomaly point according to the first acceleration discrete point and the second acceleration discrete point. The present invention adaptively compresses acceleration data according to the distribution characteristics of acceleration data corresponding to acceleration anomaly points and normal heart rate points, improving the compression efficiency and transmission real-time performance.

The invention relates to the technical field of cerebral palsy language education, and discloses a cerebral palsy language slow intervention-oriented situational interactive teaching tool, which comprises a situational interaction module used for constructing a virtual scene and realizing language training through a multi-modal interaction technology; the personalized adaptation module is used for carrying out personalized adjustment on the interaction mode and the difficulty level in the situation interaction module according to the physical condition and the language ability evaluation result of the user; the reward and feedback module is used for monitoring operation and performance of the user in real time and giving corresponding rewards according to a preset rule; the user management module is used for storing personal information, training records and evaluation data of the user; and an intelligent analysis module. By means of the voice, gesture and eye movement multi-mode interaction technology, a natural interaction mode matched with the physical condition of a patient is constructed, language training is stimulated in an all-round mode in a scene contact interaction mode, the language expression and communication ability of the patient is remarkably improved, and the training enthusiasm is enhanced.

This invention relates to a method for continuous motion prediction in patients with cerebral palsy. The method includes: acquiring sEMG data, IMU data, and ground truth joint angles of the subjects and constructing a dataset; dividing the dataset into training, validation, and test sets for each subject according to time sequence; standardizing the collected EMG and IMU data for each subject to obtain standardized sequence data; inputting the standardized sequence data of each subject into a trained prediction network, which includes parallel TCN and GAT modules. The TCN module extracts IMU temporal features, and the GAT module extracts sEMG spatial features. The two types of features are fused through a multimodal fusion module and then input into a BiLSTM network for bidirectional temporal modeling to capture the bidirectional temporal dependence of movements. Finally, a regression output module outputs the standardized predicted angles. Compared with existing technologies, this invention has advantages such as achieving continuous and accurate motion prediction for patients with cerebral palsy and enhancing cross-subject generalization ability.

The walking assisting device for the cerebral palsy children comprises a bottom frame, two grab rails and a supporting plate, the bottom frame is provided with a standing space suitable for a user to stand, and the rear portion of the standing space is open to form an access for the user to go in and out; the two grab rails are arranged on the left side and the right side of the bottom frame respectively, and each grab rail extends in the vertical direction. The supporting plate is horizontally arranged between the two grab rails, one end of the supporting plate is connected with one of the two grab rails, the other end of the supporting plate is connected with the other one of the two grab rails, and the supporting plate can slide in the vertical direction and can be selectively locked and fixed to different height positions. The walking assisting device for the children with cerebral palsy integrally forms a support design similar to a semi-enclosed support, has good stability and supporting performance, and can effectively assist the children with cerebral palsy in walking.

The invention provides a wheelchair suitable for children with cerebral palsy, and relates to the technical field of wheelchairs, according to the wheelchair, a physiotherapy cushion is mounted on a wheelchair body seat through a first connecting belt, and the lower end of a first sitting posture correction assembly is connected with the position, close to the front end, of the physiotherapy cushion through a second connecting belt; the two sides of the first sitting posture correcting assembly are installed by bypassing a backrest of the wheelchair body through third connecting belts, so that the chest of the child patient is tightly attached to the first sitting posture correcting assembly, the back of the child patient is tightly attached to the backrest of the wheelchair body, and the situation that the body of the child patient inclines forwards is reduced; the second sitting posture correction assembly is installed on the wheelchair body and used for restraining the two sides of the body of the child patient, and the situation that the body of the child patient inclines leftwards and rightwards is reduced; the hand restraining exercise assembly is installed on the first sitting posture correction assembly and used for restraining the hands of the child patient so as to reduce the phenomenon that the hands of the child patient are scratched. According to the scheme, the effect of correcting the sitting posture and the hand carving behavior of the cerebral palsy child can be improved, and rehabilitation training of the child patient is promoted.

The invention provides a neurology data analysis method and device and a medium, and relates to a data analysis technology. A database is constructed by combining data of a plurality of cerebral palsy patients, and medical images such as CT images and symptom description data of the patients are collected; therefore, the pathological part of the current patient can be predicted in combination with the data in the database and the comparison result of the image data acquired by the acquisition device for the current patient, and the display image is generated to display the predicted illness state for the patient, so that doctors can be assisted in diagnosis, and more suitable diagnosis and treatment suggestions are provided for the patient.

The present invention relates to a protein for the prevention or treatment of neurological diseases and a pharmaceutical composition containing the same. According to one aspect, the protein or polynucleotide exhibits excellent therapeutic effects in animal models of stroke, cerebral palsy, dementia, Parkinson's disease, and autism, and thus has the effect of being useful for the prevention or treatment of neurological diseases that are difficult to regenerate.

Disclosed are compounds of formula (I) wherein G1 is as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in the treatment of e.g. a neurodegenerative disorder, a movement disorder, or a brain disorder, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. (2,5-difluoro-4-(6-(((3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-λ6-sulfanone (e.g. example 12; compound no. 7) Pharmacological data on the activity of the compounds in an mAChR M4 cell-based assay are provided (e.g. table 2).TABLE 2Human M4Cpd. No.IC50 (nM)Emin (%)*113.44239.62318.5345846575.4361883746.0385607918.43101.821186.231243.42138.63*% ACh maximum at 30 μM.

This invention discloses a game-interactive fine motor training device for children with cerebral palsy, relating to the field of cerebral palsy motor training. An audio-visual interactive button is nested inside a preset base, and a first return spring is fixedly connected to the lower end of the button, with the first return spring engaging with the inner side of the preset base. A fixed top rod is fixedly connected to the inner side of the preset base, extending along the inner side of the interactive button. A guide support structure is provided on the inner side of the interactive button. This game-interactive fine motor training device for children with cerebral palsy includes a guide support structure that prompts the user whether the pressure applied is appropriate. Once the pressure is sufficient, the user can release the button, simulating fine motor operations in daily life, such as single-finger clicking or alternating pressing. The child can then determine whether their pressure application is adequate.

The present invention relates to a protein for the prevention or treatment of neurological diseases and a pharmaceutical composition containing the same. According to one aspect, the protein or polynucleotide exhibits excellent therapeutic effects in animal models of stroke, cerebral palsy, dementia, Parkinson's disease, and autism, and thus has the effect of being useful for the prevention or treatment of neurological diseases that are difficult to regenerate.

The application provides an electromyogram muscle strength prediction method suitable for hand function rehabilitation training of children with cerebral palsy, and specifically comprises the following steps: constructing a muscle strength prediction source domain network model, and using an electromyogram muscle strength database to train and test the model; proposing a gesture set and a synchronous acquisition scheme of electromyogram signals and muscle strength signals of each gesture according to the rehabilitation training requirements of children with cerebral palsy; collecting electromyogram and muscle strength data generated when healthy children perform each gesture action, optimizing the muscle strength prediction source domain network model by using a transfer learning method, and obtaining a specific muscle strength prediction model for each gesture; collecting electromyogram signals and muscle strength signals of children with cerebral palsy during rehabilitation training of different gestures, realizing muscle strength prediction by using the specific muscle strength prediction model, and evaluating the completion effect of rehabilitation gestures of children with cerebral palsy according to the error between the predicted value and the actual value. The method is conducive to formulating a specific rehabilitation scheme and evaluating the rehabilitation treatment effect by clinicians, and better promotes the rehabilitation treatment of children with cerebral palsy.

The utility model provides a head and neck flexible supporting device for rehabilitation of children with cerebral palsy, which belongs to the technical field of medical auxiliary instruments and comprises a plurality of elastic air bags. The elastic air bags are connected in a sleeved mode and limited in the sleeve lock, and the multiple elastic air bags are sequentially stacked in the vertical direction; the two ends of the telescopic connecting piece are connected with the two ends of the elastic air bag respectively, and the telescopic connecting piece is used for driving the elastic air bag to be bent in an arc mode so as to drive the two ends of the elastic air bag to be close to or away from each other. The elastic air bags are soft and elastic, in the process of supporting the head and the neck of a child patient, the hard object supporting feeling is avoided, the wearing comfort level is improved, and the neck of the child patient is sleeved with the annular elastic air bag defined by the multiple elastic air bags which are sequentially stacked, so that the neck of the child patient is more comfortable to wear. The multiple elastic air bags stacked in sequence can adapt to child patients with different neck lengths, the necks of the child patients are kept in a vertical state, and the necks of the child patients are prevented from drooping.

Methods and systems to reduce symptoms of cerebral palsy in children are disclosed herein. In one embodiment, a method for alleviating spasticity of a lower extremity caused by a brain injury includes attaching at least one electrode on a surface of patient's skin, proximate to patient's spinal cord. The method also includes subjecting the patient to a regimen of training that improves walking of the patient; applying a series of pulses to the at least one electrode while the patient is in training; and in response to applying the series of pulses to the at least one electrode, inducing stimulation in the spinal cord that alleviates spasticity of the lower extremity.

1. Name of the designed product: walking aid (for children with cerebral palsy). 2. Use of the designed product: for walking aid for children with cerebral palsy. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

The utility model provides a protective garment worn by a cerebral infarction paralyzed patient in a wheelchair, the upper part of the protective garment is a back cardigan type round collar vest, the outer sides of the left shoulder and the right shoulder of the vest are respectively sewn with a longitudinal drawstring, the lower hem of the front piece of the vest is fixedly connected with a front crotch separation blade, and the lowermost end of the front crotch separation blade is sewn with a transverse bandage; a replaceable saliva blocking towel is hung at the chest position of the front side of the front piece of the vest, the saliva blocking towel is clamped and fixed through an elastic opening of an arc-shaped shallow bag on the vest, a replaceable knee shielding blocking towel is hung on the front side of the front crotch blocking piece, and the knee shielding blocking towel is clamped and fixed through a transverse shallow bag on the vest. According to the protective clothing, the shoulders of a wheelchair patient can lean against, the upper body of the wheelchair patient can be prevented from bending forwards, the buttocks of the patient can be limited, the body of the patient can be prevented from sliding downwards, and the sitting posture of the patient can be prevented from inclining, so that the body of the patient can be kept in a normal functional position; and clothes and trousers of the patient are prevented from being polluted by saliva and fallen food.

The present invention relates to a protein for the prevention or treatment of neurological diseases and a pharmaceutical composition containing the same. According to one aspect, the protein or polynucleotide exhibits excellent therapeutic effects in animal models of stroke, cerebral palsy, dementia, Parkinson's disease, and autism, and thus has the effect of being useful for the prevention or treatment of neurological diseases that are difficult to regenerate.

Apparatus and methods for utilizing a soft robot to facilitate standing and / or walking of pediatric patients, particularly patients suffering from dyskinesia, such as cerebral palsy. Such a soft robotic device may include a fabric pneumatic actuator that, upon inflation, generates the necessary torque along upper and lower contacts of the device to assist in movement of the patient, particularly in joint extension walking, standing, or sitting-to-standing movement. Compared with a fabric pneumatic actuator with an upright or isotropic structure, the concave structure can provide a larger torque angle and can also avoid friction and extrusion generated at the glenoid fossa. The actuator is soft, light in mass, good in compliance, and capable of providing comfortable joint extension in a multi-center trajectory. The actuator can be incorporated into a joint protector or an exoskeleton, and is very suitable for sensitive, soft and weak pediatric patients with dyskinesia, especially infants with cerebral palsy.

The invention relates to the technical field of medical instruments, in particular to a cerebral palsy patient sitting posture spine correction measurement system. The data processing module is used for calculating a stress point, a stress direction and a correction force required by correction of the patient; the adjusting module is used for applying force to the corresponding position of the back of the patient according to the force bearing point, the force bearing direction and the magnitude of the correction force, the position with the minimum difference value between the spine bending angle of the patient and the normal spine bending amplitude within the range is selected as the optimal force bearing point, and force is applied to the optimal force bearing point; the angle with the minimum difference value between the spine bending angle of the patient and the normal spine bending amplitude is selected as the optimal force application angle, force is applied to the back of the patient at the optimal force application angle at the optimal force bearing point, and the optimal correction force is selected. And the pain of the patient caused by data errors is reduced.

The invention discloses a quantitative evaluation method based on multi-modal data, and the method comprises the steps: collecting plantar pressure data through two paths of pressure sensors disposed on a forefoot and a heel, and collecting shank motion data through a 6-axis IMU sensor disposed on a shank part; performing data processing and feature extraction on the plantar pressure data and the shank movement data to obtain gait parameters; and evaluating the gait parameters to generate an evaluation result. According to the method, plantar pressure data and motion sensor data are fused, a cerebral palsy child gait quantitative evaluation method meeting clinical medicine requirements is combined, and doctors are directly assisted in completing gait abnormity diagnosis, rehabilitation scheme making and curative effect tracking.

This invention discloses a magnetic resonance imaging (MRI) method for evaluating the therapeutic effect of cerebral palsy rehabilitation in children, relating to the field of medical image processing technology. The method includes: acquiring structural imaging data (T1-weighted imaging and diffusion tensor imaging) and resting-state imaging data for each child patient; extracting brain and tissue boundaries from T1-weighted imaging using a 3D-Unet segmentation model; preprocessing the resting-state and structural imaging data and aligning them to brain boundaries, then registering these data to a standard brain template for children; acquiring and normalizing multiple clinical indicators based on the standard brain template, splicing them into multi-index vector data, inputting them into a pre-trained support vector machine model, and outputting differences in clinical indicators; determining abnormal brain regions for each child based on the differences, and finally generating a multimodal fusion index analysis report to observe changes in brain function and white matter integrity before and after rehabilitation.

The invention discloses a child cerebral palsy cranial nerve injury assessment instrument and method based on big data, and relates to the field of child cerebral palsy brain, the child cerebral palsy cranial nerve injury assessment instrument comprises a first supporting plate fixed at the upper end of a mounting frame, and a placement assembly is fixed on the upper surface of the first supporting plate; the device further comprises a moving assembly fixed above the placing assembly and a collecting assembly arranged on one side of the placing assembly. The collecting assembly is pushed into the oral cavity of a patient through the moving assembly for tongue surface image collection, and the light supplementing module fixed to the surface of the collecting assembly simulates natural light, so that in the process that the collecting module collects the image in the oral cavity, the influence of the dark environment in the oral cavity on image collection is reduced; meanwhile, the tongue surface is fixed through the tongue depressor, movement and reflection of the tongue can be restrained, the tongue root can be further exposed, and completeness and clearness of the tongue root image are improved.

The invention relates to the technical field of child cerebral palsy rehabilitation, and discloses a cerebral palsy child treatment method based on the cooperation of suspension training and transcranial magnetic stimulation, and the method comprises the following steps: S1, carrying out the baseline evaluation of a spastic lateral cerebral palsy child, the assessment content comprises a coarse movement function obtained through a coarse movement test scale of the cerebral palsy children, a muscular tension level obtained through improved Ashworth muscular tension rating, an infant development level obtained through a Bayley-III infant development scale, and an affected side muscle group activation mode obtained through pre-monitoring of surface myoelectricity equipment. Multi-dimensional baseline evaluation of coarse motor function, muscular tension, developmental stage and affected side muscle group activation mode is carried out on a spastic lateral cerebral palsy child patient, a collaborative parameter rule of repeated transcranial magnetic stimulation and suspension training is formulated based on an evaluation result, the affected side muscle group activation state and a healthy and affected side ratio are monitored in real time in training, and intervention is adjusted. Accurate adaptation between central nervous regulation and control and peripheral exercise training is achieved.

The present invention provides a method for predicting the risk of cerebral palsy in children with BIPI. The method comprises: obtaining a data set; the data set is a brain MRI image of a child with BIPI; building an automatic lesion segmentation model for the child with BIPI; obtaining a lesion segmentation result; constructing a KD grading prediction model; obtaining a Kidokoro score result; constructing a lesion feature extraction network model; automatically extracting the image features of the brain MRI image of the child with BIPI corresponding to the data set; constructing a cerebral palsy risk prediction model for the child with BIPI, and using the quantitatively converted GMs evaluation result as the output of the prediction model; integrating the image features of the brain MRI image corresponding to the data set, the quantitatively converted Kidokoro score result, and the perinatal clinical index data into a combination, and using the combination as the input of the prediction model; obtaining a cerebral palsy risk prediction result for the child with BIPI. The cerebral palsy risk prediction model for the child with BIPI of the present invention incorporates multidimensional factors to comprehensively evaluate the risk of cerebral palsy in the child with BIPI, innovatively improving the accuracy and practicality of early prediction.

The utility model discloses a brain paralysis scissors gait correction training assistive device which comprises a partition plate and a moving part, the partition plate comprises an avoiding groove, the moving part can move back and forth in the length direction of the avoiding groove, the moving part comprises a base, the base is located below the partition plate, idler wheels are arranged on the lower portion of the base, and a guide table is arranged on the upper portion of the base. A connecting rod is arranged on the upper portion of the guide table, the upper end of the connecting rod is higher than the partition plate, and a handle is arranged at the upper end of the connecting rod. During use, two legs of a child patient are separated and located on the two sides of the partition plate, the hands hold the handrails, the partition plate is arranged to prevent the feet of the child patient from crossing, and therefore active training is achieved.