Application of sodium phenylbutyrate and metabolites thereof in preparation of medicine for preventing or treating chemotherapy-induced peripheral neuropathic pain

A metabolite, sodium phenylbutyrate technology, applied in the field of medicine to achieve the effect of increasing the threshold of mechanical pain paw withdrawal, significant analgesic effect, and improving demyelination
CN113679705APending Publication Date: 2021-11-23ZHAOKE PHARMA GUANGZHOU
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHAOKE PHARMA GUANGZHOU
Publication Date
2021-11-23

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Abstract

The invention discloses application of sodium phenylbutyrate and metabolites thereof in preparation of a medicine for preventing or treating chemotherapy-induced peripheral neuropathic pain. Animal experiments prove that the sodium phenylbutyrate has a remarkable analgesic effect on paclitaxel-induced peripheral neuropathic pain of a mouse, the mechanical pain foot retraction threshold value of the mouse can be obviously increased, the photo-thermal pain foot retraction incubation period of the mouse is obviously prolonged, and the condition of demyelination of medullary nerve fibres in sciatic nerves of the mouse caused by paclitaxel is improved. The sodium phenylbutyrate can be used for preparing the medicine for preventing or treating chemotherapy-induced peripheral neuropathic pain, has no obvious toxic or side effect, and has a good application prospect.
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Description

technical field

[0001] The invention belongs to the field of medicines, in particular to the application of sodium phenylbutyrate and metabolites thereof in the preparation of medicines for preventing or treating peripheral nerve pain caused by chemotherapy. Background technique

[0002] Chemotherapy-induced peripheral neuropathy (CIPN) is the damage caused by chemotherapy drugs to peripheral nerve function, as well as a series of symptoms and signs of neurological dysfunction. Peripheral neurotoxicity is a common dose-limiting toxicity of chemotherapy drugs. An increase in the dose of chemotherapy drugs can lead to peripheral neuritis, which generally manifests as symmetrical, sensory disturbances starting from the fingers (toes), conscious numbness, and aggravated by cold. As the disease progresses, it can be manifested as loss of touch, pressure, vibration, and extremity extremities, tendon reflexes, etc., and needle-like pain.

[0003] Peripheral neurotoxicity is usuall...

Claims

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