Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain

A neuropathic pain, technology for use, applied in the field of treatment of neuropathic pain, 2-fluoro-β-D-glycoside compounds and their pharmaceutically acceptable salts, esters and solvates, can solve the problem of neuralgia that is not suitable for screening medications etc.

Inactive Publication Date: 2010-09-22
YUNNAN UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hot plate, tail flick, and writhing are classic animal models commonly used to screen acute pain analgesics, but they are not suitable for screening neuralgia drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain
  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain
  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of 2-fluroin-beta-D-glycoside compounds with a compound of the following formula as the ligand in preparing medicaments for treating neuropathic pain, , wherein the glycosyl part is any of pyranose or furanose, with the representative compound of 2-fluroin-beta-D-galactopyranoside which has the structural formula shown in the specification. The compound shows specific effect in treating neuropathic pain by single gastric infusion and continuous gastric infusion on a traditional sciatic nerve chronic compression injury model (CCI).

Description

technical field The present invention relates to pharmaceutical compounds in the fields of medicine, sanitation and chemistry, in particular to the use of 2-fluoro-β-D-glycoside compounds and pharmaceutically acceptable salts, esters and solvates thereof for treating neurogenic pain. Background technique According to the duration of pain, pain is clinically classified into two types: acute pain and chronic pain. These two types of pain have essential differences in the mechanism of occurrence. Acute pain is called nociceptive pain, that is, pain caused by tissue trauma. With the repair of tissue trauma, the pain stops naturally. Analgesics, such as narcotic analgesics and non-steroidal antipyretic analgesics, can be used during the onset Chronic pain is mainly neurogenic pain, its pathogenesis is complex, and it is difficult to cure it. It is a new field of basic and clinical research and drug development of pain medicine. It has risen abroad for about 30 years, and has a r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7034A61K31/195A61P25/04A61P25/00
Inventor 戴晓畅肖涵杨蓉
Owner YUNNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products