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Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain

A technology for neurogenic pain and sciatica, which is applied in the fields of medicine, hygiene and chemistry, and can solve problems such as unsuitable screening of drugs for treating neuralgia

Inactive Publication Date: 2011-11-09
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] Hot plate, tail flick, and writhing are classic animal models commonly used to screen acute pain analgesics, but they are not suitable for screening neuralgia drugs

Method used

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  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain
  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain
  • Application of 2-fluroin-beta-D-glycoside in treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0057] The specific pharmacological experiments are as follows:

[0058] 1. Test drug

[0059] Name: 2-fluoro-β-D-galactopyranoside (XH004)

[0060]

[0061] Appearance: white crystal

[0062] Source: Synthesized by the Biochemical Pharmacology Group of the Natural Resources Medicinal Chemistry Laboratory of Yunnan University.

[0063] Drug preparation, administration volume, and administration route: before use, add 0.2% pure aqueous solution of carboxymethylcellulose sodium to grind and suspend to the desired concentration. Rats were intragastrically administered once a day, and the administration volume was 45mg / Kg, 10mL / Kg.

[0064] 2. Comparative drugs

[0065] 1. Gabapentin, purchased from Sigma, CAS Number: 60142-96-3.

[0066] 2. Gastrodin, provided by Kunming Pharmaceutical Factory, batch number: 200610036.

[0067] Just before use, grind and suspend 0.2% sodium carboxymethylcellulose in pure aqueous solution to a concentration of 45 mg / mL.

[0068] 3. Exper...

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Abstract

The invention relates to application of 2-fluroin-beta-D-glycoside compounds with a compound of the following formula as the ligand in preparing medicaments for treating neuropathic pain, , wherein the glycosyl part is any of pyranose or furanose, with the representative compound of 2-fluroin-beta-D-galactopyranoside which has the structural formula shown in the specification. The compound shows specific effect in treating neuropathic pain by single gastric infusion and continuous gastric infusion on a traditional sciatic nerve chronic compression injury model (CCI).

Description

technical field [0001] The present invention relates to pharmaceutical compounds in the fields of medicine, sanitation and chemistry, in particular to the use of 2-fluoro-β-D-glycoside compounds and pharmaceutically acceptable salts, esters and solvates thereof for treating neurogenic pain. Background technique [0002] According to the duration of pain, pain is clinically classified into two types: acute pain and chronic pain. These two types of pain have essential differences in the mechanism of occurrence. Acute pain is called nociceptive pain, that is, pain caused by tissue trauma. With the repair of tissue trauma, the pain stops naturally. Analgesics, such as narcotic analgesics and non-steroidal antipyretic analgesics, can be used during the onset Chronic pain is mainly neurogenic pain, its pathogenesis is complex, and it is difficult to cure it. It is a new field of basic and clinical research and drug development of pain medicine. It has risen abroad for about 30 ye...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/195A61P25/04A61P25/00
Inventor 戴晓畅肖涵杨蓉
Owner YUNNAN UNIV
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