Application of 4-formylphenyl-beta-D-glucoside compounds in treating chronic neuropathic pains
A technology of neurogenic pain and formylphenyl, which is applied in the fields of medicine, health and chemistry, can solve the problems of unsuitable screening of drugs for treating neuralgia
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[0053] The specific pharmacological experiments are as follows:
[0054] 1. Test drug
[0055] Name: 4-Formylphenyl-β-D-xyloside (XH014)
[0056]
[0057] Appearance: white crystal
[0058] Source: Synthesized by the Biochemical Pharmacology Group of the Natural Resources Medicinal Chemistry Laboratory of Yunnan University.
[0059] Drug preparation, administration volume, and administration route: before use, add 0.2% pure aqueous solution of carboxymethylcellulose sodium to grind and suspend to the desired concentration. Rats were intragastrically administered once a day, and the administration volume was 45mg / Kg, 10mL / Kg.
[0060] 2. Comparative drugs
[0061] 1. Gabapentin, purchased from Sigma, CAS Number: 60142-96-3.
[0062] 2. Gastrodin, provided by Kunming Pharmaceutical Factory, batch number: 200610036.
[0063] Just before use, grind and suspend 0.2% sodium carboxymethylcellulose in pure aqueous solution to a concentration of 45 mg / mL.
[0064] 3. Experime...
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