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Drug for oral local anesthesia of pregnant woman and preparation method thereof

A local anesthesia and drug technology, applied in the direction of anesthetics, drug combinations, pharmaceutical formulations, etc., can solve problems such as affecting the fetus, hypoxia, teratogenicity, etc., achieving good anesthesia effect and improving safety.

Inactive Publication Date: 2015-11-11
密夫丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Changes in the heart rate and blood pressure of pregnant women during anesthesia may affect the fetus, making it prone to hypoxia and hypercapnia, and even some anesthetic drugs have teratogenic effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 injection

[0058] Recipe: Asarum 12g, Banzhilian 9g, Licorice 18g, Forsythia 22g, Jiulixiang 5g, Sanfensan 1g, Dajinhua 1g, Cnidium 4g, Cyperus Cyperi 12g, Arborvitae leaves 16g, Hemp leaves 0.8g, Nantian bamboo 0.8g, mint 12g, ligusticum 18g, celandine 0.6g, horse tooth seven 1g, magnolia 13g, duck celery 12g, Tianwang seven 12g, duhuo 10g, juniper 12g, citronella 15g, tianjiu 12g, Golden belt 9g, Datura leaf 1g and Armillaria 15g;

[0059] Its preparation method is:

[0060] In the first step, the raw medicinal materials are mixed in proportion, put into an ultrafine pulverizer and pulverized into a mixed powder composed of micron-sized particles with a volume average particle size of 1 μm and nano-sized particles with a volume average particle size of less than 0.1 μm. The powder yield of said mixed powder is 98%;

[0061] In the second step, in the mixed powder obtained in the first step, add ethanol with an alcohol concentration of 85% relative to ...

Embodiment 2

[0063] Embodiment 2 powder injection

[0064] Recipe: Asarum 17g, Banzhilian 12g, Licorice 16g, Forsythia 18g, Jiulixiang 5g, Sanfensan 1g, Dajinhua 1g, Cnidium 4g, Cyperus Cyperi 2-15g, Arborvitae leaves 17g, Hemp leaves 0.8 g. Nantian bamboo 0.8g, mint 12g, ligusticum 16g, celandine 0.5g, horse tooth seven 1g, magnolia 15g, duck celery 12g, Tianwang seven 12g, solitary life 10g, juniper 12g, citronella 15g, day leek 12g, Golden Belt 10g, Datura Leaf 1g and Armillaria 12g;

[0065] Its preparation method is:

[0066] In the first step, the raw medicinal materials are mixed in proportion, put into an ultrafine pulverizer and pulverized into a mixed powder composed of micron-sized particles with a volume average particle size of 2 μm and nano-sized particles with a volume average particle size of less than 0.1 μm , the powder yield of the mixed powder is 97%;

[0067] In the second step, add ethanol with an alcohol concentration of 90% relative to the mass of the mixed powde...

Embodiment 3

[0069] Embodiment 3 paste tablet

[0070] Recipe: Asarum 18g, Banzhilian 9g, Licorice 16g, Forsythia 16g, Jiulixiang 5g, Sanfensan 2g, Dajinhua 1g, Cnidium 4g, Cyperus cyperi 16g, Hemp leaves 0.8g, Nantian bamboo 0.8g, mint 17g, ligusticum 18g, celandine 0.6g, horse tooth seven 1g, magnolia 12g, duck celery 12g, Tianwang seven 13g, duhuo 9g, juniper 13g, lemongrass 17g, tianjiu 12g, Golden belt 13g, Datura leaf 1g and Armillaria 12g;

[0071] Its preparation method is:

[0072]In the first step, mix Jiulixiang, Sanfensan, Yangjinhua and Cnidium Fructus according to the stated ratio, dissolve it in ethanol with an alcohol concentration of 85% which is 3 times the mass of the obtained mixture, heat and reflux for 2 hours and then extract, Filtrate to obtain the first filtrate; dissolve the filter residue with ethanol with an alcohol concentration of 85% that is twice the mass of the obtained mixture again, heat and reflux for 2 hours, extract, and filter to obtain the second f...

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Abstract

The invention discloses a drug for oral local anesthesia of a pregnant woman and a preparation method thereof. The drug is prepared from herba asari, sculellaria barbata, liquorice, fructus forsythiae, folium et cacumen murrayae, acutangular anisodus roots, flos daturae, fructus cnidii, rhizoma cyperi, cacumen biotae, hemp fimble leaves, common nandina fruit, mint, rhizoma ligustici, greater celandine herbs, pseudobulb of fimbriate calanthe, flos magnoliae, cryptotaenia japonica hassk, roots of featherycleft horsegentian, radix angelicae pubescentis, juniper berries, lemongrass herbs, plantainlily-leaved onion herbs, drooping stringbush flower roots and bark, stramonium leaves and halimasch. The drug for the oral local anesthesia of the pregnant woman and the preparation method thereof have the advantages that the drug is used for the oral local anesthesia of the pregnant woman, the anesthetic effect is good, oral treatment is conducted after anesthesia, the painful feeling does not exist, side effects on a patient do not exist, the safety is greatly improved, and a fetus is not affected.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for oral local anesthesia of pregnant women and a preparation method thereof. Background technique [0002] Before pregnancy, various examinations are usually carried out to rule out a series of predictable diseases, and to improve various physical conditions, so as to better prepare for pregnancy and delivery. However, in many cases at present, some pregnancies are not ready, so It is possible to face many unpredictable diseases, such as dental caries during pregnancy is one of them. [0003] Many people suffer from dental caries or tooth decay. Because dental caries or tooth decay does not attack and cause pain under normal circumstances, many people ignore his existence. For some female friends, once pregnant, due to the improvement of some conditions during pregnancy , it will cause dental caries or tooth decay to occur, the milder ones are ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P23/02
Inventor 密夫丽张伟
Owner 密夫丽
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