31 results about "Neuromuscular Blockade" patented technology

An electrode assembly adapted to be attached to the skin over selected facial muscle groups picks up signals to be analyzed by an anesthesia adequacy monitor that measures the level of awareness of a living animal, typically a human being. The electrode assembly also includes a stimulator that stimulates a facial nerve to determine the level of paralysis, or neuro muscular block, of the facial muscles. Also disclosed is a method of manufacturing the electrode assembly by printing a pattern of electrically conductive material through a silk-screen or an ink type process onto a flexible layer, and then coating the result with a non-conducting adhesive except at points corresponding to sensing points for the desired muscle groups. Finally, a method for using such sensing and stimulating devices is shown in determining and maintaining an appropriate level of patient awareness, muscle paralysis, and analgesia under anesthesia.

An electrode assembly adapted to be attached to the skin over selected facial muscle groups picks up signals to be analyzed by an anesthesia adequacy monitor that measures the level of awareness of a living animal, typically a human being. The electrode assembly also includes a stimulator that stimulates a facial nerve to determine the level of paralysis, or neuro muscular block, of the facial muscles. Also disclosed is a method of manufacturing the electrode assembly by printing a pattern of electrically conductive material through a silk-screen or an ink type process onto a flexible layer, and then coating the result with a non-conducting adhesive except at points corresponding to sensing points for the desired muscle groups. Finally, a method for using such sensing and stimulating devices is shown in determining and maintaining an appropriate level of patient awareness, muscle paralysis, and analgesia under anesthesia.

A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. A controller in communication with the neuromuscular model is configured to receive the at least one torque or impedance command and controls at least one of position, torque and impedance of the robotic limb joint.

Improved sensors and sensing methods for detection of Neuromuscular Blockade (NMB), for example to improve monitoring generally, as well as facilitate automated NMB drug administration. The methods, systems, devices, etc., herein can increase the quantity and quality of data available. The methods, etc., include translation between commonly available sensing types, use of partially saturated sensor measurements, use of a model of neurotransmitter storage and release and sophisticated use of more than one sensor simultaneously. These methods are aided by new sensors and methods of decreasing electrical noise. An implementation of the methods, systems, devices, etc., herein is automated drug delivery for NMB, whether through an advisor system or through with full computer control.

A computer-implemented method for quantitatively determining a person's neuro-muscular blockade (NMB) level in real-time using at least one sensor attached to the person is provided. The method includes receiving a first input signal from the sensor, wherein the first input signal includes a measurement of a first muscular response, the first muscular response resulting from a baseline stimulus current delivered to the person before administration of NMB agents to the person, and establishing a baseline chronaxie based on the first input signal. The method also includes delivering one or more stimulus currents to the person after the administration of NMB agents to the person, receiving a second input signal from the sensor, wherein the second input signal includes a measurement of one or more muscular responses resulting from the one or more stimulus currents, and determining the person's NMB level based on the second input signal.

The invention aims to provide an anesthesia depth monitoring device and an anesthesia depth monitoring method. According to the anesthesia depth monitoring device disclosed by the invention, by carrying out analysis and transverse comparison on a bispectral index, noxious stimulation data and neuromuscular blockade depth data, injection medicine is respectively controlled, the interference of the neuromuscular blockade recovery and the noxious stimulation strengthening on the electroencephalogram monitoring anesthesia depth is effectively eliminated and the monitoring on the electroencephalogram anesthesia depth can accurately and effectively reflect an anesthesia depth value of a patient. Meanwhile, by the anesthesia control of carrying out interference elimination on the monitoring on the electroencephalogram anesthesia depth and then carrying out optimization, the anesthesia depth can be controlled stable like a straight line, the machine control of the integral anesthesia process is implemented, the condition of judging the anesthesia process mainly by the anesthesia experience of a doctor is changed, the influence of the individual difference of patients is overcome, the safety of the anesthesia process is furthest ensured and the anesthesia depth monitoring device and the anesthesia depth monitoring method have high social values and a wide application prospect.

This application describes methods of making and using physiological cysteine solutions useful for reversing a neuromuscular blockade caused by a cysteine-reversible neuromuscular blockade agent, that overcomes problems of cysteine precipitation and dimerization.

The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) wherein R is (a), (b) or (c); or general formula (B) wherein X is (a), (b) or (d), or a pharmaceutically acceptable salt thereof.

The invention describes antibiotics, muscle relaxants and plant extracts that have neuromuscular blockade effects as well as methods of use thereof. These compounds can be used in the same clinical settings as botulinum toxin and may be used topically, thereby providing an advantage over botulinum toxin in terms of application and ease of use. The compounds can be used in pharmaceutical compositions for the treatment of involuntary muscle spasms and neuropathic pain and in cosmetic compositions for the treatment of facial wrinkles. Also provided are kits useful for therapeutic and / or cosmetic applications.

The invention discloses a multiple-address controllable miniature neuromuscular blockade electrical stimulation system and belongs to the field of medical apparatuses and instruments. The multiple-address controllable miniature neuromuscular blockade electrical stimulation system comprises an in-vitro controller and multiple in-vivo miniature electrical stimulators, each in-vivo miniature electrical stimulator is provided with a fixed address, the in-vitro controller controls synchronous working of each miniature electrical stimulator through an instrument and provides energy required by electrical stimulation through wireless radio frequency and transmits an electrical stimulation command. The system multiple-address controllable miniature neuromuscular blockade electrical stimulation system sends the instrument to control the synchronous working of each miniature electrical stimulator through one in-vitro controller, achieves multiple-muscle-group coordinated exercise, perfects basic exercise of a human body, effectively solves the multiple-muscle-group coordinated shrinkage problem, and solves the problem that a traditional implanted product can only simulate muscle groups and the problem of replacement operation caused by battery service life.

The invention aims at providing an anaesthetic balance control device. The device comprises a data filter module and a drug balance control module. Pre-stored electrocerebral indexes, noxious stimulation data drug usage data are divided into electrocerebral index-sedative data and noxious stimulation data-sedative data. Corresponding drug target control indexes are selected according to electrocerebral index and noxious stimulation data changes in certain period, threshold values are preset, and injection of muscle relaxants are increased or stopped based on the set threshold values. Meanwhile, bispectral index, noxious stimulation data, neuromuscular retarding depth data change tendency slope and the like can be analyzed dynamically, and transverse balance adjusting control is performed on three signals. The invention further provides a work method of the device. According to the device and the method, the problem the imbalanced usage of three drugs is solved, effects of individual differences are prevented, the safety during anesthesia is guaranteed to the largest extent, and good social values and application prospects are provided.

Methods and kits for treating or reducing the likelihood of neurotoxin-induced respiratory failure in a subject, such as a victim of neurotoxic envenomation are provided. Also provided are methods for treating or reducing the likelihood of residual neuromuscular blockade in a subject to whom a nondepolarizing neuromuscular blocking agent has been administered. The methods involve administering a pharmaceutically effective dose of an acetylcholinesterase inhibitor to the subject, where the administration is not via injection. In some embodiments intra-nasal or ocular administration is used.

Sensors are provided for monitoring neuromuscular blockade in patients. In one embodiment, a sensor includes a first flexible substrate including a sensing element for measuring patient response to a stimulus, a second flexible substrate for providing the stimulus, the second flexible substrate including at least two electrodes, the first flexible substrate not connected to the second flexible substrate, and a common connector coupled to both the first flexible substrate and the second flexible substrate, the connector configured to couple to an NMT monitoring device.

The present invention relates to compounds suitable for treating, ameliorating and / or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel.

The present disclosure relates to various methods for determining a neuromuscular blockade status and systems suitable for performing such methods. The present disclosure further relates to electro-stimulation electrodes for stimulating a muscle of a patient, optionally in the context of at least some of the mentioned methods. The present disclosure still further relates to hybrid air-signal connectors for use in an electro-stimulation cuff which can be used in the context of at least some of the cited methods. The present disclosure also relates to electro-stimulation circuits comprising an electrode portion and a track portion suitable for pressure cuffs for electro-stimulation, and to pressure cuffs configured to be arranged around a limb of a patient and comprising an active electro-stimulation electrode and a passive electro-stimulation electrode. These electro-stimulation circuits and pressure cuffs may also be used in the context of at least some of the mentioned methods.

Provided are methods for reversing the effects of agents used for muscular immobilization and / or loss of consciousness and / or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and / or anesthetic agents such that the effects of the agent(s) are partially fully reversed.

The present disclosure relates to various methods for determining a neuromuscular blockade status and systems suitable for performing such methods. The present disclosure further relates to electro-stimulation electrodes for stimulating a muscle of a patient, optionally in the context of at least some of the mentioned methods. The present disclosure still further relates to hybrid air-signal connectors for use in an electro-stimulation cuff which can be used in the context of at least some of the cited methods. The present disclosure also relates to electro-stimulation circuits comprising an electrode portion and a track portion suitable for pressure cuffs for electro-stimulation, and to pressure cuffs configured to be arranged around a limb of a patient and comprising an active electro-stimulation electrode and a passive electro-stimulation electrode. These electro-stimulation circuits and pressure cuffs may also be used in the context of at least some of the mentioned methods.

Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction / neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed.

The invention discloses a new compound for muscle relaxation antagonism. The new compounds of theta type, beta type, gamma type, lambda type, kappa type, nu type, tau type, omega type, upsilon type and the like of sugammadex sodium have less hygroscopicity and better storage stability, are more beneficial to quality control of medicines and preparations and the like, and are suitable for preparingspecific binding neuromuscular block antagonists. And the compound can be applied to drugs for antagonizing treatment or prevention of neuromuscular block induced by rocuronium bromide or vecuroniumbromide and the like.

The present invention relates to compounds suitable for treating, ameliorating and / or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel.

Methods and systems are provided for monitoring neuromuscular blockade in patients during surgical procedures. In one embodiment, a system includes a stimulator, an electromyography (EMG) sensor, a kinemyography (KMG) sensor, and a single connector configured to couple each of the stimulator, the EMG sensor, and the KMG sensor to a patient monitoring device via a single input. In this way, neuromuscular transmission (NMT) monitoring in patient may be done reliably by ensuring that NMT measurement from a first sensor (EMG sensor) is in line with the measurement of the second sensor (KMG sensor).

A neuromuscular blocking preparation for blocking and / or alleviating a vasospasm is provided, the preparation comprising a plurality of gas-or a gas precursor-filled microspheres, and a neuromuscular blocking agent. Methods for using such a preparation for blocking and / or alleviating a vasospasm are also provided.

The invention aims at providing an anaesthetic balance control device. The device comprises a data filter module and a drug balance control module. Pre-stored electrocerebral indexes, noxious stimulation data drug usage data are divided into electrocerebral index-sedative data and noxious stimulation data-sedative data. Corresponding drug target control indexes are selected according to electrocerebral index and noxious stimulation data changes in certain period, threshold values are preset, and injection of muscle relaxants are increased or stopped based on the set threshold values. Meanwhile, bispectral index, noxious stimulation data, neuromuscular retarding depth data change tendency slope and the like can be analyzed dynamically, and transverse balance adjusting control is performed on three signals. The invention further provides a work method of the device. According to the device and the method, the problem the imbalanced usage of three drugs is solved, effects of individual differences are prevented, the safety during anesthesia is guaranteed to the largest extent, and good social values and application prospects are provided.

This application describes methods of making and using physiological cysteine solutions useful for reversing a neuromuscular blockade caused by a cysteine-reversible neuromuscular blockade agent, that overcomes problems of cysteine precipitation and dimerization.

The present disclosure relates to compounds suitable for treating, ameliorating and / or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein can inhibit the ClC-1 ion channel.

Devices and methods for stimulation and recording of muscle responses for determining degree of neuromuscular blockade, particularly relevant to elicitation of such responses in those under the influence of anesthesia. A system for estimating the degree of neuromuscular blockade includes at least one stimulating electrode, at least one recording electrode, a pulse generator for providing stimulation to a nerve through the stimulating electrode, and a computing device configured to: apply stimuli to the nerve according to a stimulation protocol, wherein the stimulation protocol provides a plurality of stimulation sequences that vary in frequency of pulses in the stimulation sequence, frequency of the stimulation sequences, number of pulses in the stimulation sequence, or all of the above; measure, by the recording electrode, electrical responses of a muscle; and estimate the degree of neuromuscular blockade based on changes in the electrical responses of the muscle during a stimulation sequence.