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Isolation liquid and method for preparing same

A technology of spacer solution and medicinal salt, which is applied in the field of spacer solution and its preparation, can solve problems such as thermal injury of the recurrent laryngeal nerve, and achieve the effects of low cost, novel formula and simple operation

Inactive Publication Date: 2017-06-30
NO 411 HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides an isolation solution and a preparation method, which are used to solve the problem of thermal injury to the recurrent laryngeal nerve in the thermal ablation of the thyroid gland, while taking into account the complications of intraoperative pain and bleeding

Method used

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  • Isolation liquid and method for preparing same
  • Isolation liquid and method for preparing same
  • Isolation liquid and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A spacer fluid containing the following components by weight per 1L:

[0021] Lidocaine or its medicinal salt 5.6mmol

[0022] Epinephrine or its medicinal salt 0.138mmol

[0023] Add to 1L normal saline

[0024] Add lidocaine or its pharmaceutically acceptable salt and epinephrine or its pharmaceutically acceptable salt into physiological saline and mix uniformly to obtain the spacer solution.

Embodiment 2

[0026] A spacer fluid containing the following components by weight per 1L:

[0027] Lidocaine or its medicinal salt 7mmol

[0028] Epinephrine or its medicinal salt 0.092mmol

[0029] Add to 1L normal saline

[0030] The preparation method is the same as in Example 1.

Embodiment 3

[0032] A spacer fluid containing the following components by weight per 1L:

[0033] Lidocaine or its medicinal salt 8.4mmol

[0034] Epinephrine or its medicinal salt 0.046mmol

[0035] Add to 1L normal saline

[0036] The preparation method is the same as in Example 1.

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Abstract

The invention discloses isolation liquid. The isolation liquid comprises normal saline, lidocaine or pharmaceutical salts thereof and epinephrine or pharmaceutical salts thereof. The invention further provides a method for preparing the isolation liquid with the lidocaine or the pharmaceutical salts thereof and the epinephrine or the pharmaceutical salts thereof. The isolation liquid and the method have the advantages that the isolation liquid can be injected into front and back envelopes of thyroids and dangerous trigona in thyroid thermal ablation surgery, accordingly, important tissue structures of recurrent laryngeal nerves, superior laryngeal nerves, oesophagi, tracheas and the like can be sufficiently isolated and protected, and the purposes of realizing definite local pain relieving effects and effectively controlling bleeding around the envelopes of the thyroids during isolation can be achieved; the isolation liquid is viscous and fluidic and is convenient to inject into the front and back envelopes of the thyroids and the dangerous trigona, the staying time of the isolation liquid in tissues can be prolonged owing to the viscosity of the isolation liquid, and repeated isolation liquid injection operation can be omitted; the isolation liquid is difficult to diffuse in the tissues, and accordingly the surgery can be facilitated; the method is easy to implement, and clinical operation requirements can be met.

Description

technical field [0001] The invention relates to a spacer and a preparation method thereof. Background technique [0002] Ultrasound-guided thyroid ablation has been widely used clinically in recent years. Recurrent laryngeal nerve injury is one of the common complications in thermal ablation treatment of benign thyroid nodules and recurrent thyroid cancer. How to reduce or avoid thermal injury of recurrent laryngeal nerve is a must during ablation. Key technical problems to be solved. At present, the "liquid barrier method" is often used clinically to avoid thermal injury to the recurrent laryngeal nerve. The liquid barrier method is often used clinically with 0.9% sodium chloride injection, but in clinical applications, it is found that patients who use 0.9% sodium chloride injection as the barrier solution often experience pain during the operation, and the degree of cooperation decreases, and some have to suspend the operation. Moreover, bleeding is easy around the thyr...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K31/167A61K31/137A61P29/00A61P7/04
CPCA61K31/137A61K31/167A61K31/728A61K2300/00
Inventor 陈涵刘胜胡平方
Owner NO 411 HOSPITAL OF PLA
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