GLP-1 (Glucagon-like peptide-1) injection and preparation method thereof

A GLP-1 and injection technology, applied in the field of medicine, can solve problems such as adverse reactions

Inactive Publication Date: 2019-06-21
王广生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Commonly used drugs may cause adverse reactions in the body. Therefore, it is necessary to ...

Method used

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Embodiment Construction

[0030] The following examples are only used to further describe the present invention and the preparation method of exenatide injection in detail, and the scope of the present invention cannot be construed as being constituted only by the following examples.

[0031] GLP-1 injection, including the following components:

[0032] components measurement Exenatide 25mg Mannitol 4.0g Phenyl alcohol 0.5g glacial acetic acid 0.105g Sodium acetate trihydrate 0.171g Water for Injection Add to 100ml

[0033] The preparation method of GLP-1 injection comprises the following:

[0034] Step 1: Dissolve phenylethyl alcohol, mannitol, glacial acetic acid, and sodium acetate trihydrate in turn with water for injection and move them into the batching tank. The amount of water for injection should be more than 75% of the total volume of the liquid medicine;

[0035] Step 2: After the auxiliary materials are completely dissolved, take an appr...

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PUM

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Abstract

The invention relates to GLP-1 (Glucagon-like peptide-1) injection, comprising GLP-1, an isotonic agent, a buffer agent, a preservative and a solvent, wherein the GLP-1 is an effective ingredient, theisotonic agent is one, or a combination, of mannitol, sorbitol, inositol, glycerol, xylitol, and polyethylene glycol, the buffer agent is one, or a combination, of an acetate, a phosphate, a citrateand a glutamate, the preservative is one, or a combination, of chlorobutanol and phenethyl alcohol, the solvent is injection water, and the GLP-1 injection has pH of 4.0-6.0. The GLP-1 injection preparation prepared according to the invention is tested to meet the related specifications in terms of traits, identification, related matters, contents and other indexes. The preservative polyethylene glycol can inhibit bacteria and provide local pain relief, and the GLP-1 injection is better than proprietary prescriptions, and has the advantages of good quality stability and suitability for long-term storage.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a GLP-1 injection and a preparation method thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Commonly used drugs may cause adverse reactions in the body. Therefore, it is necessary to develop a more ideal therapeutic approach to control blood sugar for patients with type 2 diabetes. [0003] Exenatide (also known as Exenatide or Exenatide) is a synthetic exendin-4, which is an analogue of human glucagon-like peptide-1 (GLP-1). The sequence partially overlaps with the amino acid sequence of GLP-1, so it has the same physiological function as GLP-1. When GLP...

Claims

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Application Information

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IPC IPC(8): A61K38/26A61K9/08A61K47/10A61P3/10A61P31/04A61P29/00A61K31/045
Inventor 王广生
Owner 王广生
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