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Method for preparing compound biological activity sterilizing fluid

A technology of biological activity and disinfectant, applied in botany equipment and methods, chemicals for biological control, disinfectants, etc., can solve the problem of increasing skin and mucous membrane irritation, affecting the effect of sterilization and disinfection, and decreasing the stability of active iodine, etc. problem, achieve water-soluble broad-spectrum bactericidal effect, good biocompatibility, and reduce the volatilization of iodine

Inactive Publication Date: 2009-09-09
山东贝诺医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original micellar force of this kind of products with surfactant as the carrier will be destroyed after dilution, so that the stability of active iodine will decrease, and the concentration of free iodine will increase, which not only affects its sterilization and disinfection effect, but also increases the effect on skin and mucous membranes. the irritation of

Method used

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  • Method for preparing compound biological activity sterilizing fluid
  • Method for preparing compound biological activity sterilizing fluid
  • Method for preparing compound biological activity sterilizing fluid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 0.5g of low molecular chitosan and dissolve it in 60ml of 0.2% glacial acetic acid aqueous solution, add 5g of didodecyl diquaternary ammonium salt under stirring conditions, as 1 solution, mix 2g of povidone iodine in 35ml Swell in water as 2 liquids, mix 1 liquid and 2 liquids evenly, add sodium hydroxide test liquid to adjust the PH value to 4.5.

Embodiment 2

[0019] Take 1.0g of low molecular chitosan and dissolve it in 70ml of 0.2% glacial acetic acid aqueous solution, add 4g of didodecyl diquaternary ammonium salt under stirring conditions, as a solution, add 1g of povidone iodine in 25ml Swell in water as 2 liquids, mix 1 liquid and 2 liquids uniformly, add sodium hydroxide test liquid to adjust the PH value to 3.1.

Embodiment 3

[0021] Take 1.5g low molecular chitosan quaternary ammonium salt and dissolve in 70ml water, add 3.5g didodecyl diquaternary ammonium salt under stirring conditions, as 1 solution, swell 0.5g povidone iodine in 25ml water as 2 liquids, mix 1 liquid and 2 liquids evenly, add triethanolamine to adjust the PH value to 6.0.

[0022] The low-molecular-weight chitosan quaternary ammonium salt or low-molecular-weight chitosan solution of the present invention has the following general formula:

[0023]

[0024] Among them, R1 and R2 are hydrocarbon groups, and the general formula of R1 is C n H 2n (n = 1, 2, 3, 4, 5...), the general formula of R2 is C n H 2n+1 (n=1, 2, 3, 4, 5...).

[0025] The povidone-iodine of the present invention has the following general formula:

[0026]

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Abstract

The invention discloses a method for preparing compound biological activity sterilizing fluid, which comprises the steps: a proper amount of surface active agent is added to low molecular chitosan quaternary ammonium salt or low molecular chitosan solution under a stirring condition to be used as first fluid, povidone iodine is swelled to be used as second fluid, and the first fluid and the second fluid are evenly mixed according to a proper proportion and are regulated to a prescriptive range by a chemical reagent to obtain the compound biological activity sterilizing fluid. The prepared compound biological activity sterilizing fluid uses low molecular chitosan and povidone as double carriers, the chitosan not only can strengthen the bacterium inhibiting and sterilizing effects of the povidone iodine, but also has a certain adsorbing function for iodine released by the povidone iodine, causes the release of the iodine to be doubly controlled to reduce the volatilization of the iodine and increase the release uniformity of the iodine, the chitosan has degradability, the skin mucosa protecting function and the bacterium inhibiting function, therefore, the compound biological activity sterilizing fluid is stable and environmental-friendly and has high efficiency, low toxicity, low irritation and the skin protecting function.

Description

Technical field [0001] The invention relates to a disinfectant, in particular to a preparation method of a compound biologically active disinfectant. Background technique [0002] Povidone-iodine is a complex of iodine and polyvinylpyrrolidone (PVP). It has the advantages of film formation, adhesion, detoxification, chronic release, strong water solubility, and broad-spectrum bactericidal effect ("Chinese Pharmacopoeia" 2005 edition, Clinical medication instructions. 2001.911), povidone-iodine has been more and more widely used in the sterilization and disinfection of skin and mucous membranes, surgery and instruments. However, the original micellar power of such products with surfactants as carriers will be destroyed after dilution, which will reduce the stability of active iodine and increase the concentration of free iodine, which not only affects its sterilization and disinfection effects, but also increases the effect on the skin and mucous membranes. Irritating. Chitosan is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K9/08A61K47/36A61K47/34A01N59/12A01N43/16A01P1/00A61P31/02A61K31/722
Inventor 惠培业刘维峰
Owner 山东贝诺医药生物科技有限公司
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