73 results about "Phenyl alcohol" patented technology

An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.

The invention discloses a method for separating acetophenone and alpha-phenethyl alcohol from a mixture of the acetophenone and the alpha-phenethyl alcohol. The method comprises the following steps: (1) adding acetophenone and alpha-phenethyl alcohol to a material tank, controlling the temperature, the evaporation temperature, the reflux ratio and the vacuum degree of a molecular distillation and rectification coupling system rectification column, and respectively separating to obtain two components of a light component and a heavy component; (2) adding the light component to the material tank, controlling the temperature, the evaporation temperature, the reflux ratio and the vacuum degree of the molecular distillation and rectification coupling system rectification column, so as to obtain high-purity acetophenone; and (3) adding the heavy component to the material tank, controlling the temperature, the evaporation temperature, the reflux ratio and the vacuum degree of the molecular distillation and rectification coupling system rectification column, so as to obtain high-purity alpha-phenethyl alcohol. According to the separation method, the defects of conventional reduced pressure rectification and molecular distillation are compensated; the method is short in separation time and simple in flow; low-energy consumption and high-efficiency separation of two mixtures can be achieved; and the method is economic, environment-friendly, and easy to achieve industrialization.

The present invention is process of preparing 2, 3, 5, 6-tetrafluoro phenyl alcohol as one important material for synthesizing tetrafluoro phenyl pyrethrin through the reduction reaction of 2, 3, 5, 6-tetrafluoro benzoyl chloride material under the action of solvent, reductant and assistant.

The invention discloses novel esterase, encoding gene and an application thereof in splitting (+/-)-1-phenethyl alcohol and (+/-)-styralyl acetate. The amino acid sequence of the esterase is shown in SEQ ID NO.2 and the nucleotide sequence is shown in SEQ ID NO.1. Asymmetric hydrolysis is carried out on the (+/-)-styralyl acetate in an aqueous phase and (S)-styralyl acetate with the enantiomer excess value being 95% and (R)-1-phenethyl alcohol with the enantiomer excess value being more than 99% are obtained; and asymmetric transesterification is carried out on the (+/-)-1-phenethyl alcohol in an organic phase and (R)-styralyl acetate with the enantiomer excess value being 99% and (S)-1-phenethyl alcohol with the enantiomer excess value being more than 70% are obtained. Compared with the traditional chemical splitting phase, the novel esterase, the encoding gene and the application disclosed by the invention have the advantages of mild reaction condition, no pollution and high enantiomer excess value and the obtained product can be used for synthesizing corresponding medicines after being simply purified.

The invention discloses a synthesis method of crizotinib serving as an antitumor molecular targeting medicament, which belongs to the field of pharmacy and relates to a novel splitting process of a chiral isomer of a crizotinib precursor and a synthesis method of an intermediate. (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol is prepared by splitting a 1-(2,6- dichloro-3-fluorophenyl)ethanol racemic body into S-alcohol and R-alcohol with a catalytic splitting method for combining Boc-L-proline(N-tert-butoxycarbonyl-L-proline), paratoluenesulfonic acid serving as a catalyst and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride, separating and purifying; the yield is 60 percent; and the excessive fraction ee) of the chiral enantiomer is 99 percent. According to the method, time is shortened, cost is reduced, the generation of waste acids is avoided, environmental pollution is lowered, column chromatography isolation is not required, and industrial production is easier to implement.

The invention provides a bio-preparation method for (R)-3,5-bis(trifluoromethyl) phenyl ethanol (I). The method specifically comprises the following steps: (a) an asymmetric reduction reaction is performed in a liquid reaction system with a compound shown in the formula II as a substrate in presence of a coenzyme under catalysis of carbonyl reductase, and a compound shown in the formula I is prepared, wherein in the reaction system, the concentration of the compound shown in the formula II is 50-1,000 g/L; (b) the compound shown in the formula I is optionally separated from the reaction system subjected to the reaction in the step (a). The invention further provides the reaction system. The reaction system comprises (i) a waterborne solution, (ii) the substrate which is the compound shown in the formula II, (iii) the coenzyme, (iv) carbonyl reductase, (v) a co-substrate and (vi) an enzyme for regenerating the coenzyme.

The invention discloses a preparation method of hydroxylated graphene powder with a controllable conductive performance. The electrical resistivity of the powder is controlled in a range of 10<-4>ohm.m-10<5>ohm.m. The method comprises the following steps: ultrasonically treating oxidized graphene in distilled water to obtain a uniformly dispersed oxidized graphene aqueous solution; adding hydrazine hydrate and ammonium water, and condensing and refluxing in an oil bath to obtain a turbid liquid of graphene and water; then, adding amino phenyl alcohol and isoamyl nitrite and condensing and refluxing to obtain a hydroxylated graphene aqueous solution; filtering to obtain a neutral solution; and freezing and drying to obtain the hydroxylated graphene powder with the controllable conductive performance. The hydroxylation degree of graphene is controlled by controlling the rate of charge of amino phenyl alcohol and oxidized graphene so as to control the conductivity of the hydroxylated graphene powder. The hydroxylated graphene powder is safe, environmental friendly, is free of inert gas protection and foreign ions, is fluffy and is not agglomerated, is high in degree of purity, is excellent in quality and is good in solubleness.

The present invention relates to a novel compound S-(−)-1-{4-[2-(allyloxy)-ethyl] phenoxy}-3-isopropylamino propan-2-ol of formula 1 and to a process for the preparation thereof. More particularly the present invention relates to a process for preparing S-(−)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of formula 1 by selective allylation of p-hydroxy phenyl ethanol. The present invention also relates to a process for conversion thereof to S-(−)-betaxolol of formula 2

The invention discloses 4-(2-(2-methyl sulfoxide)ethyl)-4-nitrobenzene)morpholine shown in the formula (I) and preparation and application thereof. A preparation method includes the steps that 2-(2-chlorine-5 nitro)phenethyl alcohol shown in the formula (II) and morpholine are mixed to prepare 2-(2-morpholine-5-nitrobenzene)ethanol shown in the formula (III); bis(trichloromethyl)carbonate ester, a sodium methyl mercaptide aqueous solution and an aqueous hydrogen peroxide solution are sequentially added dropwise to 2-(2-morpholine-5-nitrobenzene)ethanol shown in the formula (III), and finally 4-(2-methyl sulfoxide)ethyl)-4-nitrobenzene)morpholine is prepared. According to the application of 4-(2-methyl sulfoxide)ethyl)-4-nitrobenzene)morpholine, the obtained Swern reagent reacts with an alcohol compound shown in the formula (IV), and aldehyde or ketone is prepared after after-treatment. The defects of an existing Swern oxidation method are overcome, generation of a stink byproduct dimethyl sulfide and toxic carbon monoxide is avoided from the source, the reaction temperature is increased to be -30 DEG C to 0 DEG C, and an odorless byproduct novel sulfur ether can be recycled and reused. The formulas are shown in the description.

The present invention provides an improved process for preparation of 2-phenyl ethanol. More specifically, the present invention relates to a process for preparing 2-phenyl ethanol by catalytic transfer hydrogenation of styrene oxide, in the presence of a supported transition metal catalyst. The catalyst system comprises of a palladium supported on silica, alumina, clay or charcoal.

The invention provides a synthesis method of (R)-2-p-nitrobenzene ethylamine-1-phenethyl alcohol and salt thereof, belongs to the technical field of medicine synthesis and solves the problems that in the prior art the cost is high, the product yield is low, the synthesis method is not applicable to large-scale industrial production, and the like. The synthesis method comprises the following steps of: under the action of an oxidant, oxidizing hydroxyl on p-nitrobenzene ethanol into an aldehyde group so as to obtain p-nitrobenzene acetaldehyde; under the action of a reducing agent, carrying out dehydration, condensation and reduction on amino on (R)-2-amino-1-phenethyl alcohol and the aldehyde group on p-nitrobenzene acetaldehyde so as to obtain (R)-2-p-nitrobenzene ethylamine-1-phenethyl alcohol; and mixing a rough product of (R)-2-p-nitrobenzene ethylamine-1-phenethyl alcohol with an acid so as to generate precipitate or stirring till solid (R)-2-p-nitrobenzene ethylamine-1-phenethyl alcohol salt is separated out. The synthesis method of (R)-2-p-nitrobenzene ethylamine-1-phenethyl alcohol and the salt thereof is low cost and high in product yield, and is applicable to large-scale industrial production.

The invention belongs to the technical field of chemical engineering and in particular relates to a method for preparing alpha-phenethyl alcohol by catalyzing acetophenone hydrogenation with a supported amorphous alloy. An amorphous alloy catalyst consists of copper, nickel, boron and a porous carrier material Z, wherein the copper mainly exists in a mode of a Cu-Ni-B amorphous alloy. The preparation method comprises the following step: reducing active components, namely copper and nickel, into a carrier through BH4-. The catalyst is low in raw material price and safe to use, is applied to reactions for preparing phenethyl alcohol through acetophenone hydrogenation, and has good stability and selectivity when being compared with a conventional nickel-based catalyst; and when the acetophenone conversion rate is up to 98% or greater, the selectivity of alpha-phenethyl is up to 97%, and the activity of the catalyst after 300 hours of reactions is still maintained at a high level.

The invention discloses an alcohol dehydrogenase mutant with improved activity and stereoselectivity, a recombinant vector of alcohol dehydrogenase mutant, a genetically engineered bacterium containing the recombinant vector, and an application of the alcohol dehydrogenase mutant and the genetically engineered bacterium. The alcohol dehydrogenase mutant is mutated by taking wild type alcohol dehydrogenase as shown in SEQ ID NO.1 as a template. The 188th site of the wild type alcohol dehydrogenase plays a key role in improving stereoselectivity, and the 93rd site plays a key role in activity. According to the mutant N188L/Q93L of the alcohol dehydrogenase provided by the invention, (S)-1-(2, 6-dichloro-3-fluorophenyl) ethanol can be prepared by catalyzing 2, 6-dichloro-3-fluoroacetophenonewith high activity and high stereoselectivity, the activity and the stereoselectivity of various ketones are improved, and the mutant N188L/Q93L is more suitable for industrial production and has a wide application prospect.

The invention discloses a preparation method and an application of effective ingredients of a rose fragrance emitting agent for cigarettes. The method comprises the following steps: utilizing a Cohen-Kohler reaction to prepare phenylethyl2,3,4,6-4-O-acetyl-beta-D-glucopyranoside; acetylizing glucose under the catalysis of perchloric acid and reacting with hydrogen bromide; removing solvent and recrystallizing in aether to obtain a white crystal of alpha-acetyl-1-bromoglucose; carrying out a photophobic reaction of the white crystal of alpha-acetyl-1-bromoglucose, phenylethyl alcohol and silver carbonate in a ratio of 1:2:1, removing the solvent and purifying by gel chromatography columns to obtain a purified phenylethyl2,3,4,6-4-O-acetyl-beta-D-glucopyranoside product. The prepared phenylethyl2,3,4,6-4-O-acetyl-beta-D-glucopyranoside cracks about 350 DEG C and can emit rose fragrance in main smoke and branch smoke. The prepared rose fragrance emitting agent uses the phenylethyl2,3,4,6-4-O-acetyl-beta-D-glucopyranoside as a main ingredient, can effectively emit objective fragrance ingredients and has the advantages of simple and easily-obtained raw materials, low cost and simple reaction equipment.

The invention discloses a process for preparing a knitwear cashmere fluff treating agent. The process comprises the following steps: (1) mixing and uniformly stirring the following components in parts by mass: 1-2 parts of hydroxypropyl methyl cellulose, 25-30 parts of ethyl acrylate, 7-8 parts of sodium hexametaphosphate, 25-30 parts of polyoxyethylene octyl phenyl alcohol, 15-17 parts of stearic acid, 2-3 parts of hydroxymethyl acrylamide, 4-5 parts of potassium persulfate and 185-190 parts of water; and (2) adding 5-7 parts by mass of paraffin, 10-15 parts by mass of polypropylene glycol and 6-8 parts by mass of 1,4-butanediol for mixing, heating to the temperature of 50-60 DEG C, stirring so as to completely and uniformly mix the materials, and cooling to room temperature, thus obtaining the finished product. The prepared knitwear cashmere fluff treating agent has a good anti-pilling effect.

The invention belongs to the field of the pharmaceutical preparation, relates to a desonide preparation, and in particular to a more optical stable desonide preparation which uses phenylethyl alcohol and/or benzyl alcohol and/or 2-phenoxyl ethanol and/or sorbic acid as antiseptics of the desonide preparation to replace the antiseptics methyl-p-hydroxybenzoate and propyl p-hydroxybenzoate. Each component in the desonide preparation does not disturb a related substance detection system. Related substances meet control limitations of related substance guiding principles of chemical medicaments, and photosensitiveness of the preparation is obviously improved. In a contrast investigation of illumination influence factors, the related substance degraded amplitude and the content decrease amplitude in the desonide preparation are all obviously reduced, and the product stability is improved significantly.

This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-phenylalanine, styrene or substituted styrene to a plurality of enzyme catalyzed chemical transformations in a one-pot reaction system, using recombinant microbial cells overexpressing the enzymes. To produce phenylacetaldehyde from styrene, the cells are modified to overexpress styrene monooxygenase (SMO) and styrene oxide isomerase (SOI). To produce phenylacetic acid from styrene, SMO, SOI and aldehyde dehydrogenase are overexpressed. Alternatively, to produce 2-phenylethanol, SMO, SOI and aldehyde reductase or alcohol dehydrogenase are overexpressed, while to produce phenylethylamine, SMO, SOI and transaminase are overexpressed.

The invention discloses an application of carbonyl reductase BaSDR1 or engineering bacteria containing carbonyl reductase BaSDR1 in asymmetric reduction of latent chiral ortho-haloacetophenone to prepare chiral ortho-halo-alpha-phenyl ethanol. The latent chiral ortho-haloacetophenone has the general structural formula represented by the formula (I), wherein X is one of F, Cl and Br; R1 is hydrogenor halogen. The chiral alcohol with high optical purity can be synthesized with greenness, high efficiency and high stereoselectivity.

The invention discloses an amiotide eye drop containing a composite bacteriostatic agent. The composite bacteriostatic agent is phydroxybenzoate ester and phenethyl alcohol, wherein the concentration of the phydroxybenzoate ester is 0.1 to 0.4g/L; the concentration of the phenethyl alcohol is 4 to 5ml/L; and the phydroxybenzoate ester is one of or a mixture of more than two of methyl parahydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate. Through the combined collaborative bacteriostatic action of the phydroxybenzoate ester and the phenethyl alcohol, the amiotide eye drop can improve the bacteriostatic activity, enhances the microbial contamination resistance, expands the antibacterial spectrum and has relatively high inhabitation effect on gram-negative bacterium, gram-positive bacterium and fungi. The potency assay of the bacteriostatic agent proves that the amiotide eye drop completely accords with the rule of a bacteriostatic agent efficacy test method guiding principle, which is the appendix of 'China Pharmacopeia 2000 (vol. II)', and the safety and the efficiency of the amiotide eye drop can satisfy clinical needs.

The invention provides a strain for producing beta-phenethyl alcohol. The classification name of the strain is Enterobacter sp., and the preservation number of the strain is CGMCC No. 15641. The invention further provides a method using the strain to produce beta-phenethyl alcohol. The method includes: activating the Enterobacter, performing liquid fermentation, and performing tank fermentation; performing concentration extraction on the beta-phenethyl alcohol. Detection shows that beta-phenethyl alcohol yield can reach up to 0.5g/L. The Enterobacter MF024 is good in genetic stability, low inculture cost and the like. The fermentation and extraction method is mild in reaction condition, low in cost, environmentally friendly and the like. The obtained beta-phenethyl alcohol is green and natural and has great industrial application advantages.

The invention discloses a novel preparation method of (5R, 6S)-5,6-dephenyl -2-morpholinone (I). The novel preparation method comprises the following reaction steps: enabling (1S, 2S)-2-chloro-1, 2-diphenylethanol (II) to react with glycine to generate 2-[(1R, 2S)-2-hydroxyl-1,2-diphenylethylamino] acetic acid (III); salifying the compound (III) and acid to form 2-[(1R, 2S)-2-hydroxyl-1,2-diphenylethylamino] ethanoic acid salt (IV); and enabling the compound (IV) to be subjected to ring closing reaction under the action of a ring closing reagent to obtain (5R,6S)-5,6-dephenyl -2-morpholinone (I).

The invention provides an anti-pilling agent for a wool fabric. The anti-pilling agent consists of the following materials in parts by mass: 15-20 parts of ethyl acrylate, 15-20 parts of polyoxyethylene octyl phenyl alcohol, 10-15 parts of zinc nitrate, 5-8 parts of stearic acid, 5-8 parts of sodium sulfate, 2-4 parts of n-butyl alcohol, 2-4 parts of potassium tartrate, 1-3 parts of chitosan, 2-4 parts of sodium dihydrogen phosphate, 70-80 parts of ethyl alcohol and 320-360 parts of water. The invention also provides a preparation method of the anti-pilling agent. By virtue of the anti-pilling agent, the anti-pilling grade of the wool fabric can be enhanced by over two levels and the hydrophilicity can be kept the same fundamentally.