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Catalytic rectifying apparatus for splitting chirality 1-phenethyl alcohol by virtue of lipase and method for producing chirality 1-phenethyl

A technology of catalytic rectification and phenylethanol, applied in enzyme production/bioreactors, biochemical equipment and methods, fractionation, etc., can solve problems such as difficult to obtain high product conversion rate, achieve reduced contact time and high optical purity , the effect of high reaction conversion rate

Inactive Publication Date: 2018-09-04
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The kinetic resolution process of traditional racemic 1-phenylethanol uses the tank reactor method, which has the advantages of simple operation and low equipment investment, but due to a certain degree of equilibrium inhibition and rate inhibition in the reaction system, It is difficult to obtain a high product conversion rate

Method used

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  • Catalytic rectifying apparatus for splitting chirality 1-phenethyl alcohol by virtue of lipase and method for producing chirality 1-phenethyl

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The operating pressure of the catalytic rectification column used was 300 mBar. 1-Phenylethyl alcohol is continuously fed from the upper feed port of the reaction section after being preheated to 60°C. Ethyl butyrate is continuously fed from the feed port at the lower part of the reaction section after being preheated to 60°C. The molar ratio of feed 1-phenylethanol to ethyl butyrate is 1:3. 1-phenylethanol and ethyl butyrate react under the catalysis of the lipase catalyst loaded in the reaction section to generate R-ester and ethanol. The temperature of the tower kettle is 109-110°C, and the tower kettle reboiler provides the rising gas phase for the upper sections. The top reflux ratio of the catalytic rectification tower is 2.0, the temperature is 50-51°C, and the ethanol product is extracted from the top.

[0031] After testing, the conversion rate of R-1-phenylethanol in the catalytic rectification tower is ≥99.0%, the mass fraction of ethanol in the production ...

Embodiment 2

[0033] The operating pressure of the catalytic rectification column used was 500 mBar. 1-Phenylethyl alcohol is continuously fed from the upper feed port of the reaction section after being preheated to 60°C. Methyl butyrate is fed continuously from the feed port at the lower part of the reaction section after being preheated to 60°C. The molar ratio of feed 1-phenylethanol to methyl butyrate is 1:2. 1-phenylethanol and methyl butyrate react under the catalysis of the lipase catalyst loaded in the reaction section to generate R-ester and methanol. The temperature of the tower kettle is 94-95°C, and the tower kettle reboiler provides the ascending gas phase for the upper sections. The top reflux ratio of the catalytic rectification tower is 2.4, the temperature is 47-48°C, and the methanol product is extracted from the top.

[0034] After testing, the conversion rate of R-1-phenylethanol in the catalytic rectification tower is ≥ 99.5%, the mass fraction of methanol in the pro...

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Abstract

The invention relates to a catalytic rectifying apparatus for splitting chirality 1-phenethyl alcohol by virtue of lipase and a method for producing the chirality 1-phenethyl. The catalytic rectifyingapparatus is characterized by comprising a rectifying tower body with a reaction section upper material inlet, a reaction section lower material inlet, a top material outlet and a kettle material outlet, wherein the 1-phenethyl alcohol is introduced from the reaction section upper material inlet, an acyl donor is introduced from the reaction section lower material inlet, a reaction section in therectifying tower is filled with the lipase fixed on the resin and used as a catalyst, and the top material outlet discharges a reaction product fatty alcohol; and a reaction product R-type ester, non-reacted S-type 1-phenethyl alcohol and acyl donor are discharged from the bottom of the tower. By utilizing the apparatus and method of the invention, the reaction conversion rate of 99 percent of R-1-phenethyl alcohol or more can be realized, the R-type ester product with enantiomeric excess greater than 99 percent and the S-1-phenethyl alcohol with the enantiomeric excess greater than 98 percent can be obtained, the production process is greatly simplified, the device size, and the energy consumption and the operation expense are reduced.

Description

Technical field: [0001] The invention relates to a rectification device and a method for producing chiral 1-phenylethanol. Background technique: [0002] Chiral compounds refer to compounds that have two enantiomers with the same molecular structure, but the spatial structures are mirror images of each other, and their physical and chemical properties are very close, such as melting point, solubility, and the type of chemical reaction that occurs. The biochemical reactions that occur in organisms, such as the catalytic specificity of enzymes and substrates, and the immune recognition of antigens and antibodies, are all based on direct and strict chiral matching of molecules. Therefore, although the chemical formula and molecular structure of chiral compounds are exactly the same, the characteristics embodied in the living body are different according to the spatial conformation. [0003] In the production process of pharmaceuticals, pesticides, and spices with chiral stru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D3/14C12M1/40C12P41/00C12P7/22
CPCB01D3/14C12M21/18C12M23/02C12P7/22C12P41/00Y02P20/10
Inventor 王晓达李玲李帆邱挺叶长燊王红星王清莲黄智贤杨金杯杨臣陈锦溢
Owner FUZHOU UNIV
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