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Amiotide eye drop containing composite bacteriostatic agent

A technology of peptide eye drops and bacteriostatic agents, which is applied in the field of amiodinated peptide eye drops, can solve the problems of inability to meet clinical needs and hidden dangers of drug safety, and achieve enhanced anti-microbial pollution capabilities, safety and effective performance satisfaction, The effect of broadening the antibacterial spectrum

Inactive Publication Date: 2011-10-05
ZHEJIANG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen that the bacteriostatic agents of the commercially available amiodinated peptide eye drops have hidden dangers in drug safety and cannot meet the clinical needs. Therefore, how to screen out suitable bacteriostatic agents has become a technical problem that needs to be solved urgently in this field.

Method used

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  • Amiotide eye drop containing composite bacteriostatic agent
  • Amiotide eye drop containing composite bacteriostatic agent
  • Amiotide eye drop containing composite bacteriostatic agent

Examples

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Effect test

preparation example Construction

[0025] The preparation method of extract in the following examples is:

[0026] ①Thyroid extract: Take 125g of porcine thyroid, chop it into pieces, put it into a reactor with 250g of purified water, adjust the feed solution to pH8.5 with 10% sodium hydroxide solution, stir well, and use a total of 2g of Hydrolyze with trypsin for 4 hours; then hydrolyze with a total of 0.2g of neutral protease at 50°C for 4 hours, centrifuge to remove the residue, take the supernatant and add ethanol to a final concentration of 75%, remove the precipitate, filter the clear liquid, and concentrate the filtrate under reduced pressure , obtain organic iodine content 0.1%, the extract 60g of solid content 20%.

[0027]②Thyroid extract: Take 125g of porcine thyroid, chop it into pieces, put it into a reactor with 250g of purified water, adjust the feed solution to pH8.5 with 10% sodium hydroxide solution, stir well, and use a total of 2g of Hydrolyze with trypsin for 4 hours; then hydrolyze with ...

Embodiment 1

[0033]

[0034] Get thyroid extract (containing organic iodine 0.2%, solid content 40%) 17.5g and eyeball extract (solid content 30%) 126.6g, drop in the beaker; Get ethyl p-hydroxybenzoate 0.3g, phenylethyl alcohol 5.0ml , add 3ml of ethanol, stir to dissolve it completely, and put it into a large beaker; add water for injection to 900ml, add 4% sodium hydroxide solution while stirring to adjust the pH value of the solution to 6.0; add 2g of activated carbon for decolorization of the solution, and heat to keep 100°C, stirring for 10 minutes. Add water for injection to 1000ml, stir evenly, and cool to room temperature; sterilize, filter, and aseptically fill to obtain amiodinate eye drops.

Embodiment 2

[0036]

[0037]

[0038] Get thyroid extract (containing organic iodine 0.1%, solid content 20%) 35g and eyeball extract (solid content 20%) 190g, drop in the large beaker; Get propyl p-hydroxybenzoate 0.2g, phenylethyl alcohol 5.0ml, add 2ml of ethanol, stir to dissolve it completely, put it into a large beaker; add water for injection to 900ml, add 4% sodium hydroxide solution while stirring to adjust the pH value of the solution to 6.0; add 2g of activated carbon for decolorization of the solution, and heat to keep at 100°C , and stirred for 20 minutes. Add water for injection to 1000ml, stir evenly, and cool to room temperature; sterilize, filter, and aseptically fill to obtain amiodinate eye drops.

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Abstract

The invention discloses an amiotide eye drop containing a composite bacteriostatic agent. The composite bacteriostatic agent is phydroxybenzoate ester and phenethyl alcohol, wherein the concentration of the phydroxybenzoate ester is 0.1 to 0.4g / L; the concentration of the phenethyl alcohol is 4 to 5ml / L; and the phydroxybenzoate ester is one of or a mixture of more than two of methyl parahydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate. Through the combined collaborative bacteriostatic action of the phydroxybenzoate ester and the phenethyl alcohol, the amiotide eye drop can improve the bacteriostatic activity, enhances the microbial contamination resistance, expands the antibacterial spectrum and has relatively high inhabitation effect on gram-negative bacterium, gram-positive bacterium and fungi. The potency assay of the bacteriostatic agent proves that the amiotide eye drop completely accords with the rule of a bacteriostatic agent efficacy test method guiding principle, which is the appendix of 'China Pharmacopeia 2000 (vol. II)', and the safety and the efficiency of the amiotide eye drop can satisfy clinical needs.

Description

technical field [0001] The invention relates to an amiodinated peptide eye drop containing a compound antibacterial agent. Background technique [0002] Senile cataract is a very common disease of the elderly. According to statistics, among Chinese cataract patients, patients aged 50-59 account for 60%, patients aged 60-69 account for 80%, and patients over 70 years old account for more than 90%. Among the many drugs for the treatment of early senile cataract, amiodinate eye drops are the most commonly used eye drops, with remarkable curative effect and high frequency of use. Amiodopeptide eye drops currently on the market are biochemical preparations extracted from pig whole eyeballs and thyroid by trypsin and fungal protease hydrolysis. , aspartic acid, lysine and other 18 kinds of amino acids, polypeptides, nucleotides and various trace elements etc. Parabens and Gentamicin Sulfate. [0003] Guo Haoshui found in his research that gentamicin sulfate belongs to aminogly...

Claims

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Application Information

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IPC IPC(8): A61K35/55A61K9/08A61K47/10A61K47/14A61P27/12A61K35/12A61K35/30
Inventor 马凤森王海珍方多凤
Owner ZHEJIANG UNIV OF TECH
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