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Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection

A technology of lidocaine hydrochloride and cefodizime sodium, applied in the field of medicine

Inactive Publication Date: 2013-05-22
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, joint applications need to be purchased separately, and there is no combined package of cefodizime sodium for injection and 1% lidocaine hydrochloride injection on the market or in medical institutions

Method used

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  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection
  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection
  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 injection cefodizime sodium

[0030] prescription:

[0031]

[0032] making process:

[0033] (1) 250g of cefodizime sodium sterile powder (in C 20 h 18 N 6 Na 2 o 7 S 4 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0034] (2) cefodizime sodium sterile powder 500g (in C 20 h 18 N 6 Na 2 o 7 S 4 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the spe...

Embodiment 2

[0037] Example 2 Preparation of Lidocaine Hydrochloride Injection

[0038] prescription:

[0039]

[0040] making process:

[0041] (1) Add a total of 4000ml of water for injection into the liquid mixing tank;

[0042] (2) Add 50g of lidocaine hydrochloride while stirring, and stir to dissolve completely;

[0043] (3) Weigh 2.5g of activated carbon for injection in the carbon mixing cabinet, add 5125ml of water for injection to wet the activated carbon for injection, and set aside;

[0044] (4) Add the wetted activated carbon for injection and stir for 30 minutes;

[0045] (5) The solution is decarburized by coarse filtration and filtered through a 0.45 μm cartridge filter;

[0046] (6) Add water for injection to 5000ml;

[0047] (7) Adjust the pH value of the liquid to 3.5-5.5.

[0048] (8) Sterilize and filter with a 0.22 μm microporous membrane until the visible foreign matter is qualified, fill with 2ml / bottle or 5ml / bottle, sterilize, seal, and get ready.

Embodiment 3

[0049] The preparation of embodiment 3 combination packaging medicines

[0050] Combination 1: Cefodizime Sodium for Injection 0.25g and Lidocaine Hydrochloride Injection 2ml.

[0051] Combination 2: Cefodizime Sodium for Injection 0.5g and Lidocaine Hydrochloride Injection 2ml.

[0052] Combination 3: Cefodizime Sodium for Injection 1.0g and Lidocaine Hydrochloride Injection 2ml.

[0053] Combination 4: Cefodizime Sodium for Injection 2.0g and Lidocaine Hydrochloride Injection 2ml.

[0054] Combination 5: Cefodizime Sodium for Injection 0.25g and Lidocaine Hydrochloride Injection 5ml.

[0055] Combination 6: Cefodizime Sodium for Injection 0.5g and Lidocaine Hydrochloride Injection 5ml.

[0056] Combination 7: Cefodizime Sodium for Injection 1.0g and Lidocaine Hydrochloride Injection 5ml.

[0057] Combination 8: Cefodizime Sodium for Injection 2.0g and Lidocaine Hydrochloride Injection 5ml.

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Abstract

The invention relates to a pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection and in particular relates to combined application package. The pharmaceutical composition includes injection cefodizime sodium and lidocaine hydrochloride injection. During a using process, the injection cefodizime sodium is dissolved in 1% of lidocaine hydrochloride injection, so that intramuscular injection is carried out. The pharmaceutical composition not only has the broad-spectrum antibacterial action, but also can be used for relieving local pains caused by injection cefodizime sodium.

Description

technical field [0001] The present invention relates to a pharmaceutical composition of cefodizime sodium for injection and lidocaine hydrochloride injection, in particular to a sterilized injection prepared from cefodizime sodium for injection and lidocaine hydrochloride The combined application packaging belongs to the technical field of medicine. Background technique [0002] Cefodizime was invented by Hoechst in Germany. It is the world's first third-generation parenteral cephalosporin with immune enhancing function; Studies have shown that the drug can activate macrophages, increase their phagocytic activity and bactericidal rate. In vivo, cefodizime prolongs the survival of infected animals, including those infected with drug-resistant bacteria or experimentally immunocompromised. [0003] Cefodizime has a high affinity to proteins involved in cell wall synthesis in susceptible bacteria. It has a broad antibacterial spectrum, including most clinically relevant Gram-...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/167A61K9/08A61K9/19A61P31/04A61P29/00
Inventor 祝云琴
Owner 海南路易丹尼生物科技有限公司
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