Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection

A technology of lidocaine hydrochloride and cefodizime sodium, applied in the field of medicine

Inactive Publication Date: 2013-05-22
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, joint applications need to be purchased separately, and there is no combined package of

Method used

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  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection
  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection
  • Pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 injection cefodizime sodium

[0030] prescription:

[0031]

[0032] making process:

[0033] (1) 250g of cefodizime sodium sterile powder (in C 20 h 18 N 6 Na 2 o 7 S 4 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0034] (2) cefodizime sodium sterile powder 500g (in C 20 h 18 N 6 Na 2 o 7 S 4 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the spe...

Embodiment 2

[0037] Example 2 Preparation of Lidocaine Hydrochloride Injection

[0038] prescription:

[0039]

[0040] making process:

[0041] (1) Add a total of 4000ml of water for injection into the liquid mixing tank;

[0042] (2) Add 50g of lidocaine hydrochloride while stirring, and stir to dissolve completely;

[0043] (3) Weigh 2.5g of activated carbon for injection in the carbon mixing cabinet, add 5125ml of water for injection to wet the activated carbon for injection, and set aside;

[0044] (4) Add the wetted activated carbon for injection and stir for 30 minutes;

[0045] (5) The solution is decarburized by coarse filtration and filtered through a 0.45 μm cartridge filter;

[0046] (6) Add water for injection to 5000ml;

[0047] (7) Adjust the pH value of the liquid to 3.5-5.5.

[0048] (8) Sterilize and filter with a 0.22 μm microporous membrane until the visible foreign matter is qualified, fill with 2ml / bottle or 5ml / bottle, sterilize, seal, and get ready.

Embodiment 3

[0049] The preparation of embodiment 3 combination packaging medicines

[0050] Combination 1: Cefodizime Sodium for Injection 0.25g and Lidocaine Hydrochloride Injection 2ml.

[0051] Combination 2: Cefodizime Sodium for Injection 0.5g and Lidocaine Hydrochloride Injection 2ml.

[0052] Combination 3: Cefodizime Sodium for Injection 1.0g and Lidocaine Hydrochloride Injection 2ml.

[0053] Combination 4: Cefodizime Sodium for Injection 2.0g and Lidocaine Hydrochloride Injection 2ml.

[0054] Combination 5: Cefodizime Sodium for Injection 0.25g and Lidocaine Hydrochloride Injection 5ml.

[0055] Combination 6: Cefodizime Sodium for Injection 0.5g and Lidocaine Hydrochloride Injection 5ml.

[0056] Combination 7: Cefodizime Sodium for Injection 1.0g and Lidocaine Hydrochloride Injection 5ml.

[0057] Combination 8: Cefodizime Sodium for Injection 2.0g and Lidocaine Hydrochloride Injection 5ml.

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PUM

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Abstract

The invention relates to a pharmaceutical composition of injection cefodizime sodium and lidocaine hydrochloride injection and in particular relates to combined application package. The pharmaceutical composition includes injection cefodizime sodium and lidocaine hydrochloride injection. During a using process, the injection cefodizime sodium is dissolved in 1% of lidocaine hydrochloride injection, so that intramuscular injection is carried out. The pharmaceutical composition not only has the broad-spectrum antibacterial action, but also can be used for relieving local pains caused by injection cefodizime sodium.

Description

technical field [0001] The present invention relates to a pharmaceutical composition of cefodizime sodium for injection and lidocaine hydrochloride injection, in particular to a sterilized injection prepared from cefodizime sodium for injection and lidocaine hydrochloride The combined application packaging belongs to the technical field of medicine. Background technique [0002] Cefodizime was invented by Hoechst in Germany. It is the world's first third-generation parenteral cephalosporin with immune enhancing function; Studies have shown that the drug can activate macrophages, increase their phagocytic activity and bactericidal rate. In vivo, cefodizime prolongs the survival of infected animals, including those infected with drug-resistant bacteria or experimentally immunocompromised. [0003] Cefodizime has a high affinity to proteins involved in cell wall synthesis in susceptible bacteria. It has a broad antibacterial spectrum, including most clinically relevant Gram-...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/167A61K9/08A61K9/19A61P31/04A61P29/00
Inventor 祝云琴
Owner 海南路易丹尼生物科技有限公司
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