Piroxicam gel preparation and preparation method thereof

A technology of piroxicam gel and piroxicam, applied in the field of medicine, can solve the problems of poor patient compliance, insufficient curative effect, low transdermal absorption rate, etc., and achieve stable and reliable preparation quality, improved curative effect, and improved penetration. Effect

Active Publication Date: 2012-10-03
江苏小林制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing piroxicam ointment has greasy properties, and the patient's use compliance is poor
The tra...

Method used

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  • Piroxicam gel preparation and preparation method thereof
  • Piroxicam gel preparation and preparation method thereof
  • Piroxicam gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The piroxicam raw material is formulated into piroxicam gel according to the following prescription:

[0012] Preparation process

[0013] Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. Dissolve tromethamine in water with 10% of the total dosage of the prescription for subsequent use. Put piroxicam in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di The sodium solution and the piroxicam solution are added to the carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill and package, and obt...

Embodiment 2

[0015] The piroxicam raw material is formulated into piroxicam gel according to the following prescription:

[0016] Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. Dissolve tromethamine in water with 10% of the total dosage of the prescription for subsequent use. Put piroxicam in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di The sodium solution and the piroxicam solution are added to the carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill and package, and obtain piroxicam gel.

Embodiment 3

[0018] The piroxicam raw material is formulated into piroxicam gel according to the following prescription:

[0019]

[0020] Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. Dissolve tromethamine in water with 10% of the total dosage of the prescription for subsequent use. Put piroxicam in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di The sodium solution and the piroxicam solution are added to the carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill and package, and obtain piroxicam gel. ...

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Abstract

The invention provides a piroxicam gel preparation and a preparation method of the piroxicam gel preparation. The gel preparation comprises the following components in percentages by weight: 0.1-1% of piroxicam, 0.3-1.2% of Carbomer 940, 0.1-1% of tromethamine, 1-10% of ethanol, 6-15% of propylene glycol, 0.6-1.5% polyethylene glycol 400, 0.006-0.015%Edetate Disodium, and 1.2-2.1% of triethanolamine. Piroxicam is dissolved by using tromethamine to solve the problem that tromethamine is difficult to dissolve in water, the penetrability of piroxicam to the skin is improved, the absorption rate of piroxicam through the skin is increased, the curative effect is obviously improved by local topical administration for curing the local pain, and a novel administration method for the patients is also provided. The gel preparation is semi-solid gel having good transdermal absorption property; the piroxicam is completely dissolved and dispersed in the gel preparation, thereby facilitating the pain relief for the patient. The preparation process is simple, and the preparation is stable and reliable in quality.

Description

field of invention [0001] The invention relates to a piroxicam gel preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Piroxicam is the first long-acting non-steroidal anti-inflammatory and anti-rheumatic drug. Pharmacological studies have shown that the drug has high bioavailability, and its plasma half-life is as long as 36-45 hours. It has strong analgesic, anti-inflammatory and detumescence effects. Its anti-inflammatory activity is greater than that of indomethacin, phenylbutazone, ibuprofen and aspirin. It is widely used in clinical treatment of rheumatoid arthritis, acute sprain, tendinitis and thrombophlebitis. [0003] Chinese Pharmacopoeia (2005 Edition) contains tablets, capsules and injections, ointments and gel preparations. Among them, tablets and capsules take slow oral action, are more irritating to viscera and even produce toxicity. Externally administered drugs are directly absorbed in...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/5415A61K47/34A61P19/02A61P29/00
Inventor 殷雨林王福东苏传铃邓建华顾李周玉琢
Owner 江苏小林制药有限公司
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