Group of animal-derived cationic antibacterial peptides and its application
An animal-derived, antimicrobial peptide technology, applied in the direction of antibacterial drugs, peptides, peptide/protein components, etc., can solve the problems of low antibacterial activity, hemolytic toxicity, etc., achieve strong bactericidal activity, broad antibacterial spectrum, improve sterilization and inhibition The effect of bacterial activity
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[0045] 1. Preparation of antimicrobial peptides (taking the preparation of 0.1 mmol of CQUT-a as an example)
[0046] All the following reagents for the preparation of antimicrobial peptides were purchased from Applied Biosystems.
[0047] The prepared CQUT-a polypeptide sequence is: Phe-Arg-Trp-Trp-Gln-Arg-NH 2
[0048] The preparation is carried out one by one from the C-terminal to the N-terminal, and is automatically controlled by the synthesizer. First weigh 0.1 mmol of the resin combined with the first amino acid, Phe (purchased from Applied Biosystems, USA), pack it into a column, protect it with 20% piperidine dimethyl formamide solution, wash it with dimethyl formamide, 9-Fat methoxycarbonyl (Fmoc)-protected free amino acids were dissolved in carbodiimide (DCC), hydroxybenzotriazole (HOBt) / diisopropylethylamine (DIPEA), and the dissolved solution was placed on the column Cycle the coupling reaction for 30 minutes, wash with trifluoroacetic acid (TFA) and repeat the...
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