Group of animal-derived cationic antibacterial peptides and its application

Abstract

The invention provides a group of novel artificially designed animal-derived cationic antibacterial peptides, which is synthesized on the basis of a structural analysis of a natural lactoferricin antibacterial peptide sequence, the series of the antibacterial peptide sequence is shown as the following: CQUT-a: Phe Arg Trp Trp Trp Gln Arg; CQUT-b: Arg Arg Gln Trp Phe Trp. The antibacterial peptides are obtained by using a solid phase chemical method. The animal-derived cationic antibacterial peptides have the advantages that antibacterial spectrum is wide, no modification or connection is required, the structure is simple and artificial synthesis is convenient. Experiment proves that both G<+>bacteria (gram positive bacteria) and G<->bacteria (gram negative bacteria) possess the advantages of substantial bacteriostasis and bactericidal activity, long continuance and no hemolytic toxin; the animal-derived cationic antibacterial peptides have important value on aspects of exploitation and application of medicines for treating bacterial infection diseases.

Description

technical field [0001] The invention relates to the application of a group of novel animal-derived cationic antimicrobial peptides and their derivatives in the treatment of bacterial infections. The antimicrobial peptides can inhibit the growth of microorganisms and be prepared into pharmaceutical compositions for the treatment and prevention of infections caused by various microorganisms , wherein the microorganisms include Gram-positive bacteria and Gram-positive bacteria. [0002] Background technique [0003] Bacterial infectivity has always been one of the important diseases threatening human life. In the 1930s, antibiotics were discovered and widely used in clinical treatment, saving the lives of countless patients (Neu, H.C. (1992) Science 257, 1064-1073). Due to the extensive use of traditional antibiotics, the rapid growth of drug-resistant pathogenic microorganisms. Therefore, it is urgent to develop new anti-drugs to deal with the increasingly serious drug resis...

AI Technical Summary

Problems solved by technology

[0008] At present, among many antibacterial peptides, cationic bovine lactoferrin (Lactoferricin B) is the most common antibacterial peptide, especially its antibacterial core sequence Lactoferricin B 4-9 RRWQWR (Arg-Arg-Trp-Gln-Trp-Arg) still has good antibacterial activity, but there are still problems such as low antibacterial activity and hemolytic toxicity

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