The present invention provides a pharmaceutical composition comprising a
chemical compound or a
herb extract or the combination having at least one of the activities of antiviral, antibacterial,
antifungal, anti-inflammatory, anti-
allergy, anti-
cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a
disease of a
mammal. The present invention also provides a
system for delivering the composition to the hard-to-reach sinuses of a
mammal to reduce the load of the
pathogen, to reduce the amount of inflammatory mediators, to heal
pathological changes, and collectively to treat a
disease of a
mammal, such as allergic fungal rhinosinusitis. The invented method of treating a
human disease reduces infectious and inflammatory agents without causing
antibiotic resistance or adverse event. The present invention additionally provides a kit for collecting the
nasal wash specimen to analyze how much
drug is administered into sinonasal cavities or to determine the load of microbes in rhino-sinuses.