The present invention provides a pharmaceutical composition comprising a 
chemical compound or a 
herb extract or the combination having at least one of the activities of antiviral, antibacterial, 
antifungal, anti-inflammatory, anti-
allergy, anti-
cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a 
disease of a 
mammal. The present invention also provides a 
system for delivering the composition to the hard-to-reach sinuses of a 
mammal to reduce the load of the 
pathogen, to reduce the amount of inflammatory mediators, to heal 
pathological changes, and collectively to treat a 
disease of a 
mammal, such as allergic fungal rhinosinusitis. The invented method of treating a 
human disease reduces infectious and inflammatory agents without causing 
antibiotic resistance or adverse event. The present invention additionally provides a kit for collecting the 
nasal wash specimen to analyze how much 
drug is administered into sinonasal cavities or to determine the load of microbes in rhino-sinuses.