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Membrane type oxygenator with biocompatible coating

A technology of membrane oxygenator and biocompatibility, which is applied in the field of biomedical engineering, can solve the problems of reducing the blood prefill volume of the oxygenator, and achieve improved biocompatibility, high efficiency, and small blood prefill volume Effect

Inactive Publication Date: 2019-03-19
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a membrane oxygenator with a biocompatible coating. By modifying the coating on the surface of the hollow fiber membrane, the fiber membrane and blood The biocompatibility of the contact reduces the risk of thrombus formation; through the innovative design, the blood warming and oxygenation process can be carried out at the same time and the blood prefilling amount of the oxygenator can be reduced, while overcoming the blood existing in the oxygenator during the oxygenation process To solve the problem of temperature drop, improve the excessive temperature gradient in the process of blood flow, improve the exchange efficiency of blood gas, further improve the performance of oxygenator, and meet people's needs

Method used

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  • Membrane type oxygenator with biocompatible coating
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  • Membrane type oxygenator with biocompatible coating

Examples

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Effect test

Embodiment 1

[0050] Example 1 A membrane oxygenator with biocompatible coating

[0051] 1. Such as figure 1 , 2 As shown in Figure 3, a membrane oxygenator with a biocompatible coating is cylindrical as a whole, including a hollow fiber membrane oxygenation unit 7 and a heat exchange unit. There are several equal intervals in the oxygenator. Each oxygenation unit 7 is surrounded by the heat exchange unit; in addition, the oxygenator further includes a biocompatible coating coated on the surface of the hollow fiber membrane. The two processes of heat exchange and gas exchange can be realized simultaneously when blood is flowing. During the oxygenation process, since the heat exchange unit surrounds the oxygenation unit, the blood in the oxygenation unit loses less heat, the temperature gradient during blood flow is small, the heat preservation effect is better, the oxygen and blood flow in opposite directions, and the oxygenation efficiency is high.

[0052] The thickness of the biocompatible c...

Embodiment 2

[0076] Example 2 A hollow fiber membrane oxygenator with small precharge

[0077] 1. In order to further improve the comprehensive use effect of the oxygenator and reduce the precharge, the hollow fiber membrane oxygenator of this embodiment has the following improvements on the basis of embodiment 1:

[0078] Such as figure 1 , 2 , 3, a small pre-charged hollow fiber membrane oxygenator, from top to bottom are the upper end cover 1, the upper fixing plate 24, the middle and upper fixing plate 21, the middle and lower fixing plate 14, the lower fixing plate 17 and the lower end cover 18, the outside of each layer of the fixed plate is connected and sealed with the oxygenator housing 20 through a stepped flange, and the inside is connected to the inner, middle, and outer metal pipes with circumferential openings at both ends through a stepped flange. seal.

[0079] First use resin to bond the oxygenator housing 20, the upper fixing plate 24, and the upper middle fixing plate 21 throu...

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Abstract

The invention discloses a membrane type oxygenator with a biocompatible coating. The oxygenator comprises a hollow fiber membrane type oxygenation unit and heat exchange units, wherein a plurality ofoxygenation units are arranged in the oxygenator at equal intervals; each heat exchange unit surrounds the outer periphery of the corresponding oxygenation unit; and moreover, the oxygenator further comprises the biocompatible coating which coats the surface of the hollow fiber membrane. The coating of the surface of the hollow fiber membrane is modified to improve the biocompatibility of contactbetween the fiber membrane and blood, the risk of formation of thrombi is reduced, the blood cardiopulmonary bypass of the oxygenator is reduced, meanwhile, the problem that the temperature of blood is reduced in an oxygenation process of the oxygenator is solved, over-high temperature gradient in a blood flowing process is improved, blood gas exchange efficiency is improved, the performance of the oxygenator is further improved, and demands of people are met.

Description

Technical field [0001] The invention belongs to the technical field of biomedical engineering. More specifically, it relates to a membrane oxygenator with a biocompatible coating. Background technique [0002] Oxygenator, also known as artificial lung, is a necessary medical device for treating acute respiratory diseases and waiting for lung transplantation. It is also an auxiliary medical device for cardiovascular surgery. In the extracorporeal membrane oxygenation system, the oxygenator is responsible for oxygenation and temperature change. On the one hand, the oxygenator unit can achieve blood absorption O 2 And discharge CO 2 ; On the other hand, the temperature change unit can keep the blood at an appropriate temperature to improve the oxygenation efficiency. Therefore, the membrane oxygenator belongs to the biomedical engineering industry, is the core component of the extracorporeal membrane oxygenation system of life support equipment, and is a key product of a strategic...

Claims

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Application Information

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IPC IPC(8): A61M1/36A61M1/18
CPCA61M1/1623A61M1/1698A61M1/3621A61M1/3666A61M2202/0413A61M2205/36A61M2202/0021
Inventor 叶非华易国斌余振东
Owner GUANGDONG UNIV OF TECH
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