Injectable dextran hydrogel microsphere filler and preparation method thereof

A technology of hydrogel microspheres and dextran, which is applied in the field of medical cosmetology, can solve the problems of amine crosslinking agent residue, interference with emulsification stability, uneven emulsification, etc., and achieve long-term filling, uniform particle size and control, not easy to move and free effect

Pending Publication Date: 2022-03-08
杭州帕莱拉医疗科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN105348548A discloses a preparation method of dextran hydrogel microspheres, which obtains dextran microspheres by inverse emulsion cross-linking of aldylated dextran by adding an amine cross-linking agent, but there are amines Problems such as cross-linking agent residues and uneven cross-linking; CN105153440A discloses a preparation method of dextran microsphere gel. In this method, water-soluble dextran is added to the continuous oil for homogeneous emulsification, and the dextran is homogeneously emulsified by alkaline conditions. The hydroxyl group in the dextran reacts with the side chain of the amino group in the cross-linking agent to solidify into hydrogel microspheres with a certain strength. In this method, the strong alkaline environment greatly interferes with the emulsification stability, and there are problems such as uneven emulsification.

Method used

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  • Injectable dextran hydrogel microsphere filler and preparation method thereof
  • Injectable dextran hydrogel microsphere filler and preparation method thereof
  • Injectable dextran hydrogel microsphere filler and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] (1) At room temperature, fully dissolve 20 g of dextran powder with a molecular weight of 40,000 g / mol in 200 mL of dimethyl sulfoxide solution, pass nitrogen gas for 30 minutes, add 0.4 g of dimethylaminopyridine and 1 g of N, N'-carbonyl di The imidazole-activated hydroxyethyl methacrylate continued to react in the closed system for 48 hours, and then stopped the reaction. The mixed solution was dialyzed by a regenerated cellulose dialysis bag with a cut-off molecular weight of 3000kDa, and the deionized water was replaced every 4-6 hours. After 7 days of dialysis, the polymerizable dextran was obtained by freeze-drying.

[0034] (2) 2 g of polymerizable dextran obtained in step (1) is fully dissolved in 15 mL of deionized water, and 45 mg of ammonium persulfate is added to obtain dispersed phase solution A; in 35 mL of cyclohexane solution, add ) Lecithin with a mass of 0.5%, mechanically stirred, and mixed uniformly to obtain a continuous phase solution B; the tempe...

Embodiment 2

[0037](1) At room temperature, fully dissolve 20 g of dextran powder with a molecular weight of 70,000 g / mol in 200 mL of dimethyl sulfoxide solution, pass nitrogen gas for 30 min, add 0.4 g of triethylamine and 1.5 g of glycidyl methacrylate, After continuing to react in the closed system for 48h, stop the reaction. The mixed solution was dialyzed by a regenerated cellulose dialysis bag with a cut-off molecular weight of 3000kDa, and the deionized water was replaced every 4-6 hours. After 7 days of dialysis, the polymerizable dextran was obtained by freeze-drying.

[0038] (2) Take 3 g of polymerizable dextran obtained in step (1) and fully dissolve it in 15 mL of deionized water, add 45 mg of ammonium persulfate to obtain dispersed phase solution A; in 35 mL of n-hexane solution, add relative to (A+B) Span 80 with a mass of 1.5%, mechanically stirred, and mixed uniformly to obtain the continuous phase solution B; set the temperature at 30°C, add the dispersed phase solution ...

Embodiment 3

[0041] (1) At room temperature, fully dissolve 20 g of dextran powder with a molecular weight of 100,000 g / mol in 200 mL of dimethyl sulfoxide solution, pass nitrogen gas for 30 minutes, add 0.4 g of triethylamine, 0.4 g of dimethylaminopyridine, 0.5 g of N , N'-carbonyldiimidazole-activated polylactic acid grafted hydroxyethyl methacrylate and 1.5g glycidyl methacrylate continued to react in a closed system for 48h, then stopped the reaction. Dialyze the mixed solution with regenerated cellulose dialysis bags with a cut-off molecular weight of 3000kDa, replace deionized water every 4-6 hours, and freeze-dry after 8 days to obtain polymerizable dextran.

[0042] (2) 1.5 g of polymerizable dextran obtained in step (1) was fully dissolved in 15 mL of deionized water, and 45 mg of ammonium persulfate was added to obtain dispersed phase solution A; in 30 mL of n-hexane and 5 mL of cyclohexane mixed solution, Add 1.5% Span 80 and 1.5% monoglyceride fatty acid ester relative to the ...

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Abstract

The invention relates to an injectable dextran hydrogel microsphere filling agent and a preparation method thereof, and the preparation method of the injectable dextran hydrogel microsphere filling agent comprises the following steps: chemically modifying dextran to obtain polymerizable dextran, and further preparing dextran hydrogel microspheres through polymerization reaction crosslinking. And finally, uniformly mixing with an aqueous solution for injection, and fully swelling to obtain the injectable dextran hydrogel microsphere filler. The invention also provides the injectable dextran hydrogel microsphere filling agent prepared by the preparation method of the injectable dextran hydrogel microsphere filling agent. The preparation method of the injectable dextran hydrogel microspheres, disclosed by the invention, has the advantages of simple preparation method, mild conditions, few cross-linking agent residues and suitability for large-scale production, and the obtained injectable dextran hydrogel microsphere filler can realize long-acting filling and is suitable for various human body soft tissue filling occasions.

Description

technical field [0001] This application relates to an injectable dextran hydrogel microsphere filler and its preparation method, which is mainly suitable for long-acting and safe filling and medical cosmetology for soft tissue parts such as the face, nose, and lips. Background technique [0002] Aesthetic injections are a means of reducing sagging or shaping the skin by injecting fillers into the dermis or subcutaneously. Cosmetic fillers mainly include moisture fillers represented by sodium hyaluronate and non-moisture fillers represented by polymers and tissue substances. Hyaluronic acid has a high water content, and the implant feels natural, but it cannot be fixed and is basically absorbed within 6 months, requiring repeated injections; on the contrary, non-moisture fillers such as polylactic acid can be fixed by tissue reaction, but the biocompatibility is poor , and requires a large number of carrier stents, the filling effect is poor and difficult to remove, and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/50A61L27/52
CPCA61L27/20A61L27/50A61L27/52A61L2430/34A61L2400/06C08L5/02
Inventor 傅荣强杜滨阳董顺妮吴黎明
Owner 杭州帕莱拉医疗科技有限公司
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