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Medical degradable zinc-based alloy intravascular stent product

A vascular stent and a technology for degrading polymers, applied in the field of implantable vascular stent products, can solve the problems of poor controllability of corrosion rate, insufficient strength and toughness, slow corrosion rate, etc., and achieve excellent corrosion resistance, uniform corrosion, and good comprehensive performance. The effect of mechanical properties

Pending Publication Date: 2018-11-16
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, magnesium-based degradable metal materials face the problem of poor controllability of corrosion rate, and iron-based degradable metal materials face the problem of too slow corrosion rate, which will cause biological rejection similar to permanent implants in the long run. Zinc-based degradable metals face the problem of insufficient strength and toughness

Method used

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  • Medical degradable zinc-based alloy intravascular stent product
  • Medical degradable zinc-based alloy intravascular stent product
  • Medical degradable zinc-based alloy intravascular stent product

Examples

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Embodiment Construction

[0028] The following examples of the present invention are given to further illustrate the present invention, but not to limit the scope of the present invention.

[0029] The specific implementation is as follows:

[0030] During the implementation of the present invention, pure zinc (purity is 99.99%), pure lithium (purity is 99.9%), pure magnesium (purity is 99.99%), Zn-Cu and Zn-Ti master alloy are used as raw materials to prepare, and then use vacuum induction The melting furnace was melted and cast in a 6 kg high-purity graphite crucible to obtain 12 kinds of alloy ingots, and their specific chemical compositions were shown in Table 1 after being detected by ICP-AES.

[0031] The chemical composition of the medical degradable zinc-based alloy material that table 1 present invention implements

[0032]

[0033] After smelting, the zinc-based alloy materials smelted in 12 different examples were turned to remove scale and necking, fully preheated at 210°C for 3 hours, ...

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Abstract

The invention relates to the fields of a medical material and an apparatus thereof, and provides an in-vivo degradable implantable intravascular stent product. The product comprises 1) an in-vivo degradable implantable zinc-based metal material; 2) the intravascular stent product produced by the zinc-based alloy material in the step 1) is in a pipenet structure; 3) a magnesium metal film coating is uniformly distributed and deposed at the surface of the pipenet stent product; and 4) the magnesium film coating is coated with a degradable polymer coating, and the polymer coating can contains therapeutic drugs. The zinc based alloy has the advantages of excellent mechanical properties, strong corrosion controllability, and excellent compatibility. According to the intravascular stent product,surface special arrangement is benefit for keeping a complete initial structure, is benefit for stent endothelialization, reduces an inflammatory reaction, and reduces local inflammation, restenosisand thrombus risk in the stent after stent implantation.

Description

technical field [0001] The invention relates to the field of a medical material and a medical device thereof, and is an implantable vascular stent product degradable in a human body. Background technique [0002] Degradable medical devices degrade automatically after completing the established medical purpose, and do not persist for a long time, which can avoid the problems of biological inflammatory response and biomechanical incompatibility caused by the long-term existence of permanent implanted devices in the body, and the degradation products can be metabolized , non-toxic and side effects, has gradually become a research hotspot for current scientific researchers and medical staff. At present, the development of degradable medical devices in the field of interventional medicine and orthopedic repair has achieved exciting results. Degradable polymer medical devices and degradable metal medical devices have become two important directions for the development of degradab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/08A61L31/10A61L31/16A61L31/18
CPCA61L31/022A61L31/088A61L31/10A61L31/14A61L31/16A61L31/18A61L2300/216A61L2300/602A61L2300/42C08L67/04C08L5/08
Inventor 刘西伟赵轩铖杨映红赵洋王涛王川张昱昕杨明张霞蒲忠杰
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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