Application of indole-2, 3-diketone in preparing antiphlogistic medicament

The technology of an anti-inflammatory drug and indole is applied in the application field of indole-2,3-dione in the preparation of anti-inflammatory drugs, and can solve the problem that the drug is difficult to meet social needs and the like

Inactive Publication Date: 2008-07-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult for traditional medicines to meet the needs of society, and natural medicines, especially marine medicines, have become a new hot spot in the medical field.

Method used

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  • Application of indole-2, 3-diketone in preparing antiphlogistic medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of tablet

[0019] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add artificially synthesized indole-2,3-dione, and slowly heat to dissolve at 60°C with a magnetic stirrer, then gradually cool to form needles. Form orange-red crystals, repeat the above steps, and repeat the cleaning 3 times to reduce heavy metal ions. Grind the indole-2,3-dione crystals into powders passing through an 80-mesh sieve, weigh out 100 mg of indole-2,3-dione, 100 mg of lactose, and 245 mg of starch, mix them uniformly, granulate by wet method, and dry. After granulation, it is mixed with 5 mg of magnesium stearate, and compressed into tablets to make tablets with a weight of 500 mg each.

Embodiment 2

[0020] Embodiment 2: the preparation of capsule

[0021] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add artificially synthesized indole-2,3-dione, and slowly heat to dissolve at 60°C with a magnetic stirrer, then gradually cool to form needles. Form orange-red crystals, repeat the above steps, and repeat the cleaning 3 times to reduce heavy metal ions. Grind indole-2,3-dione crystals into powders passing through a 80-mesh sieve, weigh 100 mg of indole-2,3-dione, 345 mg of starch, and 5 mg of stearic acid, mix well, fill capsules, and prepare into capsules with a pure weight of 500mg each.

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Abstract

The present invention relates to an application of indole-2, 3-dione for preparing for an anti-inflammation drug. The indole-2, 3-dione is natural product or synthetic product with low toxicity, little side effect and good anti-inflammation and diminishing inflammation effects.

Description

technical field [0001] The invention relates to the application of indole-2,3-dione (MW147, indole-2,3-dione) in the preparation of anti-inflammatory drugs. Background technique [0002] Inflammation occurs locally but can also affect the whole body. Local clinical features are redness, heat, swelling, pain and dysfunction. Redness and heat are due to the expansion of local blood vessels and the acceleration of blood flow due to inflammation. Swelling is caused by local inflammatory hyperemia and exudation of blood components. [0003] During the inflammatory process, on the one hand, the damage factors directly and / or indirectly cause tissue and cell destruction, and on the other hand, the damage factors are diluted, killed and surrounded by the inflammatory hyperemia and exudative reaction. At the same time, damaged tissues can be repaired and healed through the regeneration of parenchymal and interstitial cells. Therefore, it can be said that inflammation is a unified...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K9/20A61K9/48A61P29/00C07D209/38
Inventor 岳旺刘占涛刘小红杨志宏孙勇
Owner QINGDAO UNIV
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