Composition comprising mixed herbal extract of lonicera japonica thunb and anemarrhena asphodeloides bunge preventing and treating arthritis

一种提取物、组合物的技术，应用在组合物领域，能够解决未报道或披露关节炎疾病治疗作用等问题

Inactive Publication Date: 2011-01-05
UNIV IND COOP GRP OF KYUNG HEE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, there is no report or disclosure about the therapeutic effect of the mixed herbal medicine honeysuckle and Anemarrhena extracts on arthritic diseases in the above cited documents, the disclosures of which are incorporated herein by reference

Method used

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  • Composition comprising mixed herbal extract of lonicera japonica thunb and anemarrhena asphodeloides bunge preventing and treating arthritis
  • Composition comprising mixed herbal extract of lonicera japonica thunb and anemarrhena asphodeloides bunge preventing and treating arthritis
  • Composition comprising mixed herbal extract of lonicera japonica thunb and anemarrhena asphodeloides bunge preventing and treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1: the preparation of mixed herbal medicine (KM-1) extract

[0113] 50 g of honeysuckle flower buds and 50 g of Zhimu purchased from Kyunghee Medical Center in Korea were dried, mixed together, cut into small pieces, and added to 0.7 liter of 50% ethanol. The solution was stirred at reflux for 4 hours at 85°C and the residue was filtered. The filtrate was concentrated until the volume of the solution reached 0.1 liter, and then an equal volume of n-butanol was added thereto for fractionation. After repeated fractionation, n-butanol-soluble fractions were collected, concentrated and dried to obtain 9 g of a mixed herbal extract, which was used as an experimental sample (as designated "KM-1" hereinafter).

[0114] As shown in the chromatographic analysis, it has been confirmed by chromatographic analysis that the KM-1 extract contains 3% chlorogenic acid (w / w%) and 3.5% mangiferin (w / w%).

Embodiment 2

[0115] Embodiment 2: Preparation of mixed herbal medicine (KM-2) extract

[0116] 50 g of honeysuckle flower buds and 50 g of Zhimu purchased from Kyunghee Medical Center in Korea were dried, mixed together, cut into small pieces, and added to 0.7 liter of 50% ethanol. The solution was stirred at reflux for 4 hours at 85°C and the residue was filtered. Said filtrate was concentrated and dried to obtain 40 g of a mixed herbal extract, which was used as an experimental sample (as designated "KM-2" hereinafter).

[0117] As shown in the chromatographic analysis, it has been confirmed by chromatographic analysis that the KM-2 extract contains 1.5% chlorogenic acid (w / w %) and 1.8% mangiferin (w / w %).

Embodiment 3

[0118] Embodiment 3: the preparation of mixed herbal medicine (KM-3) extract

[0119] 100 g of honeysuckle flower buds and 50 g of Zhimu purchased from Kyunghee Medical Center in Korea were dried, mixed together, cut into small pieces, and added to 0.7 liter of 50% ethanol. The solution was stirred at reflux for 4 hours at 85°C and the residue was filtered. The filtrate was concentrated until the volume of the solution reached 0.1 liter, and then an equal volume of n-butanol was added thereto for fractionation. After repeated fractionation, n-butanol-soluble fractions were collected, concentrated and dried to obtain 11 g of a mixed herbal extract, which was used as an experimental sample (as designated "KM-3" hereinafter).

[0120] Such as image 3 and Figure 4 As shown in, it has been proved by chromatographic analysis that the KM-3 extract contains 4.5% chlorogenic acid (w / w%) and 2.1% mangiferin (w / w%) (see image 3 and 4 ).

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Abstract

The present invention is related to the inventive compositions comprising the extract of mixed herbs with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE showing potent anti-inflammatory activity, therefore, it can be used as the effective and safe therapeutics or health food for treating and preventing arthritic disease.

Description

technical field [0001] The present invention relates to a composition comprising an extract of mixed herbs Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE for the prevention and treatment of arthritic diseases. Background technique [0002] Arthritis is an autoimmune disease characterized by symptoms such as pain, swelling and stiffness in the joints. The two main types of arthritis in mammals are inflammatory arthritis such as rheumatoid arthritis (RA) and osteoarthritis (OA), a condition often secondary to mechanical stress, aging, abnormal developmental conditions and / or Progressive, degenerative loss of or destroyed cartilage. Symptoms of arthritis are generally related to the spinal joints, for example, stiffness of the toes, joint suppurative psoriasis, or rheumatoid arthritis. [0003] Osteoarthritis exhibits symptoms similar to rheumatoid arthritis (RA). In particular, while osteoarthritis begins with degeneration of articular cartilage, rheumatoid art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K36/8964A61P19/02A23L1/30
CPCA23V2002/00A61K36/355A61K36/8964A23L1/3002A23L33/105A61P19/02A61P29/00A61K2300/00A23V2250/21A23V2200/306A23V2200/316A61K36/35
Inventor 朴东锡俞明哲崔道永梁馨仁白容铉许桢恩金璟洙赵龙白郑仁镐许锺铉李栽东
Owner UNIV IND COOP GRP OF KYUNG HEE UNIV
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