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Medicine for treating chronic respiratory diseases and preparation method of medicine

A technology for respiratory diseases and drugs, applied in respiratory diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as single drug efficacy, and achieve the effect of antagonizing the increase of calcium levels

Active Publication Date: 2014-07-23
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is aimed at the defect of the single efficacy of the above-mentioned existing medicines, and provides a kind of arctiin or its active product arctigenin metabolized in vivo and clinical antiasthma commonly used drug β 2 Drugs used in combination with adrenergic receptor agonist drugs, the drug can produce arctigenin and β 2 The synergistic effect of adrenoceptor agonist drugs, thereby increasing the beta 2 The antiasthmatic effect of adrenergic receptor agonist drugs, and the invention provides a method for preparing compound drug oral tablets and capsules

Method used

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  • Medicine for treating chronic respiratory diseases and preparation method of medicine
  • Medicine for treating chronic respiratory diseases and preparation method of medicine
  • Medicine for treating chronic respiratory diseases and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The dosage of each component in the drug is as follows:

[0031] Salbutamol sulfate 2 g

[0032] Arctium aglycone 50 g

[0033] Starch 150 g

[0034] Starch slurry (10%) 20 g

[0035] Magnesium Stearate 2 g

[0036] The technology of the pharmaceutical component granulation of above-mentioned addition is: first with salbutamol sulfate, arctigenin, starch, magnesium stearate, cross 100 mesh sieves; then take by weighing the salbutamol sulfate, arctigenin and starch of above-mentioned proportioning Stir and mix evenly, add starch slurry, granulate according to the conventional wet method, granulate after drying, add magnesium stearate and mix evenly, press into tablets, and then prepare 1,000 tablets, each containing 2 mg of salbutamol sulfate, 2 mg of burdock glycosides Yuan 50 mg.

[0037]

Embodiment 2

[0039] The dosage of each component in the drug is as follows:

[0040] Ephedrine hydrochloride 20 g

[0041] Arctium 80 g

[0042] Microcrystalline Cellulose 130 g

[0043] Cane sugar 55 g

[0044] Magnesium Stearate 15 g

[0045] Concentration is 65% ethanol 20g

[0046] The technology of making capsules with the pharmaceutical components of the above-mentioned additions is: first, ephedrine hydrochloride, arctiin, microcrystalline cellulose, and sucrose are passed through a 100-mesh sieve; Microcrystalline cellulose and sucrose are added into a mixer and mixed evenly, and then add 65% ethanol to make soft material; the soft material is granulated through a 20-mesh sieve, and dried by blasting at 50-60°C; Magnesium acid, mixed evenly and filled into capsules, then filled with 1000 capsules, each 0.3 g, each containing 20 mg of ephedrine hydrochloride and 80 mg of arctiside.

[0047]

Embodiment 3

[0048] Embodiment 3, the synergistic antiasthmatic experiment of guinea pig isolated smooth muscle

[0049] Take Hartley guinea pigs, weighing about 220-280g, half male and half female (purchased from the Experimental Animal Center of Beijing Academy of Military Medical Sciences, the animals were kept in a standard animal room at 23-26 °C and automatically cycled lights out for 12 h, free drinking water and diet) . After anesthesia, the trachea was stripped, cut into strips (4 mm × 8 mm), and fixed in Krebs-Henseleit buffer (124 mmol / L NaCl, 5 mmol / L KCl, 1.3 mmol / L MgSO) 4 , 2.5 mmol / L CaCl 2 , 25 mmol / L NaHCO 3 , 0.6 mmol / L NaH 2 PO 4 , 10 mmol / L glucose), 37 °C, maintained at 5% CO 2 -95% O 2 Mix gas, load 1 g load, and replace with fresh Krebs-Henseleit buffer every 30 min. After the smooth muscle is stabilized, add 10-fold serial dilution of acetylcholine (Ach) 10 -10 -10 -2 mol / L, record the shrinkage effect value of each concentration, and take the maximum sh...

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PUM

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Abstract

The invention relates to a medicine taking arctiin (or arctigenin) and beta 2 adrenergic receptor stimulant medicines as main active ingredients. The method provided by the invention is good in inflammation-diminishing effect while being used for effectively reducing the level of free calcium ions in cells and improving the relaxant effect of smooth muscle, avoids the risk of side effects caused by hormone after the long-time use of the composition of beta 2 adrenergic receptor stimulant medicines and glucocorticoids at present, and can be applied to treat chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, and in particular, to treat asthma.

Description

[0001] technical field [0002] The invention relates to a medicine for treating chronic respiratory diseases and a preparation method thereof, in particular to a medicine based on arctiin (or arctigenin) and β 2 A drug with an adrenergic receptor agonist drug as the main active ingredient and a production method thereof. Background technique [0003] Burdock (Arctium lappa L.) is a plant of the genus Arctium in the Compositae family, and is often eaten as a vegetable in Japan and Europe. In my country, it is a traditional medicinal plant, and its fruit, leaves and roots are used as medicine. The main active ingredients of Arctium Fructus are lignin components arctiin and arctigenin, among which arctiin is also converted into arctigenin after metabolism in vivo. The theory of traditional Chinese medicine believes that burdock fruit has a bitter taste and cold nature, and it returns to the lung and stomach meridian. It is often used for diseases such as wind-heat cold, cou...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/365A61P11/00A61P11/06A61K31/137
Inventor 白钢侯媛媛崔庆新方润平姜民高洁
Owner NANKAI UNIV
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