A kind of medicine for treating chronic respiratory diseases and preparation method thereof

A technology for respiratory diseases and medicines, applied in the direction of respiratory diseases, drug combinations, pharmaceutical formulations, etc., can solve the problem of single drug effect and achieve the effect of antagonizing the increase of calcium level

Active Publication Date: 2016-03-02
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is aimed at the defect of the single efficacy of the above-mentioned existing medicines, and provides a kind of arctiin or its active product arctigenin metabolized in vivo and clinical antiasthma commonly used drug β 2 Drugs used in combination with adrenergic receptor agonist drugs, the drug can produce arctigenin and β 2 The synergistic effect of adrenoceptor agonist drugs, thereby increasing the beta 2 The antiasthmatic effect of adrenergic receptor agonist drugs, and the invention provides a method for preparing compound drug oral tablets and capsules

Method used

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  • A kind of medicine for treating chronic respiratory diseases and preparation method thereof
  • A kind of medicine for treating chronic respiratory diseases and preparation method thereof
  • A kind of medicine for treating chronic respiratory diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The addition amount of each component in the medicine is as follows:

[0028] Salbutamol Sulfate 2g

[0029] Arctigenin 50g

[0030] Starch 150g

[0031] Starch slurry (10%) 20g

[0032] Magnesium stearate 2g

[0033] The process of granulating the above-mentioned pharmaceutical components is as follows: first pass albuterol sulfate, arctigenin, starch, and magnesium stearate through a 100-mesh sieve; then weigh the above-mentioned ratio of salbutamol sulfate, arctigenin, and starch Stir and mix evenly, add starch slurry, granulate according to the conventional wet method, granulate after drying, add magnesium stearate and mix evenly, and press into tablets. 50mg.

Embodiment 2

[0035] The addition amount of each component in the medicine is as follows:

[0036] Ephedrine hydrochloride 20g

[0037] Arctiin 80g

[0038] Microcrystalline cellulose 130g

[0039] Sucrose 55g

[0040] Magnesium Stearate 15g

[0041] The concentration is 65% ethanol 20g

[0042] The process of making capsules with the pharmaceutical components of the above-mentioned added amount is as follows: first pass ephedrine hydrochloride, arctiin, microcrystalline cellulose, and sucrose through a 100-mesh sieve; then take by weighing ephedrine hydrochloride, arctiin, Add microcrystalline cellulose and sucrose to the mixer and mix evenly, add 65% ethanol to make soft material; pass soft material through 20 mesh sieve to granulate, blow dry at 50-60°C; granulate with 20 mesh sieve, add stearin Magnesium acid, mixed evenly and filled into capsules, can be filled with 1000 capsules, each 0.3 gram, each containing ephedrine hydrochloride 20mg, arctiin 80mg.

Embodiment 3

[0043] Embodiment 3, synergistic antiasthma experiment of guinea pig isolated smooth muscle

[0044] Get Hartley guinea pigs, about 220-280g body weight, half male and half male (purchased from the Experimental Animal Center of Beijing Academy of Military Medical Sciences, the animals are kept at 23-26 ° C and in a standard animal room with 12h automatic cycle lights off, free to drink water and eat). After anesthesia, the trachea was stripped, cut into strips (4mm×8mm), and fixed in Krebs-Henseleit buffer (124mmol / LNaCl, 5mmol / LKCl, 1.3mmol / LMgSO 4 , 2.5mmol / LCaCl 2 , 25mmol / LNaHCO 3 , 0.6mmol / LNaH 2 PO 4 , 10mmol / L glucose), 37 ° C, keep feeding 5% CO 2 -95%O 2 Mix gas, load 1g load, and replace fresh Krebs-Henseleit buffer every 30min. After the smooth muscle was stabilized, accumulatively added 10-fold serially diluted acetylcholine (Ach)10 -10 -10 -2 mol / L, record the shrinkage effect value of each concentration, and take the maximum shrinkage value as 100% as t...

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Abstract

The invention relates to a medicine with arctiin (or arctigenin) and β2 adrenoceptor agonist medicine as main active ingredients. The medicine provided by the invention effectively reduces the level of intracellular free calcium ions and improves smooth muscle relaxation, and also has a good anti-inflammatory effect, and at the same time avoids the long-term use of the current combination of β2 adrenoceptor agonists and glucocorticoids After the risk of side effects caused by hormones, it can be applied to the treatment of chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, especially for the treatment of asthma.

Description

technical field [0001] The invention relates to a medicine for treating chronic respiratory diseases and a preparation method thereof, in particular to a medicine based on arctiin (or arctigenin) and β 2 A drug with an adrenergic receptor agonist drug as the main active ingredient and a production method thereof. Background technique [0002] Burdock (Arctium lappa L.) is a plant of the genus Arctium in the Compositae family, and is often eaten as a vegetable in Japan and Europe. In my country, it is a traditional medicinal plant, and its fruit, leaves and roots are used as medicine. The main active ingredients of Arctium Fructus are lignin components arctiin and arctigenin, among which arctiin is also converted into arctigenin after metabolism in vivo. The theory of traditional Chinese medicine believes that burdock fruit has a bitter taste and cold nature, and it returns to the lung and stomach meridian. It is often used for diseases such as wind-heat cold, cough with p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/365A61P11/00A61P11/06A61K31/137
Inventor 白钢侯媛媛崔庆新方润平姜民高洁
Owner NANKAI UNIV
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