Suppository for treating chronic cervicitis

A technology of chronic cervicitis and suppository, which is applied in the field of drugs for the treatment of chronic cervicitis, can solve the problems of inconvenience of daily life, infertility and infection of patients.

Inactive Publication Date: 2007-01-17
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various physical treatments are often used clinically, such as freezing, electric ironing, laser, infrared rays, etc., to destroy the columnar epithelium on the erosive surface of the cervix, make it necrotic and fall off, and be covered by new squamous epithelium, but there are postoperative bleeding and infection. , long healing time, the possibility of infertility caused by cervical stenosis, and many adverse reactions to vaginal delivery, and it also brings a lot of inconvenience to patients' daily life

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0089] A vaginal suppository for treating chronic cervicitis is prepared, and the preparation steps are as follows:

[0090] The hot-melt method is used to prepare suppositories. The preparation method is as follows: first prepare glycerin gelatin, that is, weigh the amount of gelatin and put it into the same amount of pure water. After it is fully swelled, it is heated and dissolved in a 37-40°C water bath. Add glycerin in proportion, stir, steam to remove excess water, add stabilizer, buffer, protective agent, stir evenly, keep the temperature at 37-40℃, add KGF-2, stir evenly and pour into the sterilized coating while it is hot In the vaginal suppository mold with lubricant, cool, cut off the overflow part of the mold mouth, demold, and seal to obtain the finished KGF-2 suppository. The ratio of glycerin, gelatin and water in glycerin gelatin is 70:20:10.

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Abstract

A medicine in the form of suppository for treating chronic cervicitis is prepared from horny cell growth factor-2, matrix, stabilizer, buffering agent and protecting agent.

Description

Technical field [0001] The present invention relates to a medicine for treating chronic cervicitis, and more specifically to a suppository for treating chronic cervicitis. The suppository is a vaginal suppository containing Keratinocyte growth factor-2 (KGF-2) . Background technique [0002] Keratinocyte growth factor-2 (Keratinocyte growth factor-2, KGF-2), also known as fibroblast growth factor-10 (FGF-10), is a member of the FGF family. It is secreted by fibroblasts and other mesenchymal cells. The specific target cells are various epithelial cells. The specific receptors are the tyrosine kinase receptors FGFR2 IIIb (KGFR) and FGFR1 IIIb, which are mainly responsible for mesenchymal cells-epithelial cells. The signal transmission between them is the cytokine that regulates the interstitial-epithelial interaction. KGF-2 specifically promotes the proliferation, differentiation and migration of epithelial cells, and is an important multifunctional signali...

Claims

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Application Information

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IPC IPC(8): A61K36/18A61K9/02A61K47/42A61P15/00A61P15/02
Inventor 杨静尹龙武李颖敖英彭仁琇夏雪雁孔锐
Owner WUHAN UNIV
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