Fish scale collagen skin care composition, fish scale collagen cosmetic and preparation method of fish scale collagen skin care composition and fish scale collagen cosmetic

Abstract

The invention discloses a fish scale collagen skincare composition, a fish scale collagen cosmetic and a preparation method of the fish scale collagen skincare composition and the fish scale collagen cosmetic. The fish scale collagen skincare composition comprises 0.05-0.5 part of fish scale collagen, 0.05-0.5 part of madecassoside and 0.5-3 parts of a purslane extract. According to the invention, the fish scale collagen, madecassoside and purslane extract are combined to repair the skin barrier, calm and relieve nerves, relieve skin inflammatory response and improve sensitive skin in multiple aspects from the aspects of sensitive skin characteristics, possible mechanisms and the like instead of treating head pain and foot pain. The fish scale collagen, madecassoside and purslane extract are derived from fish scales, centella asiatica and purslane of perches respectively, are gifts given to human beings by the nature, are green and healthy, and can endow the perches with high economic value, and through the simple synergistic effect of the three components and the extremely small component addition amount, the basic state of the skin of sensitive skin is consolidated, and the skin care effect is improved. The symptoms of itching, redness and the like after the sensitive skin is stimulated are relieved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a fish scale collagen skin care composition and a fish scale collagen cosmetic and a preparation method thereof. Background Art

[0002] With the increase of skin health awareness, people are paying more and more attention to sensitive skin. Sensitive skin is a syndrome in which the skin experiences paroxysmal or periodic burning, paroxysmal redness, tingling, itching and tightness after being slightly stimulated by the outside world, with or without persistent erythema. Sensitive skin is most likely to occur on the face. Although it is not a disease, for people with sensitive skin, poor skin condition can easily have a negative impact on their emotions. The influencing factors and occurrence mechanisms of sensitive skin are relatively complex, and the abuse of cosmetics may increase the probability of sensitive skin symptoms. Therefore, there is a great market demand for cosmetic products suitable for sensitive skin. However, the cosmetics developed for sensitive skin on the market are of varying quality. Some of them, in order to pursue immediate effects, do not hesitate to add ingredients with poor safety, while others only achieve the effect of insensitivity by lowering the threshold of sensory nerves. However, it is rare to repair the skin barrier, calm and soothe the nerves, relieve skin inflammation, and improve sensitive skin in all aspects based on the characteristics of sensitive skin and possible occurrence mechanisms (such as impaired skin barrier function, increased neurovascular reactivity, and immune inflammatory response).

[0003] As far as the ingredients of skin care compositions are concerned, common sensitive skin repair products usually contain more types of active ingredients. For example, patent CN114931530 B discloses a skin care composition with anti-allergic and repairing effects, its application, cosmetics and methods thereof. The skin care composition comprises blue copper peptide, palmitoyl tripeptide-8, carnosine, hydrogenated lecithin, bifid yeast fermentation product, asiatica glycoside, baicalin, prion pruinosa seed extract, lithospermum extract, perilla extract, purslane extract and rhizoma scutellariae extract, a total of 12 ingredients, which reduces the convenience of production. In addition, since people with sensitive skin generally advocate simplified skin care, products containing many and complicated ingredients increase the potential safety risks of sensitive skin.

[0004] In short, the sensitive skin care products on the market currently have the following disadvantages:

[0005] 1) Treating the symptoms of sensitive skin only temporarily, rather than repairing the skin barrier, calming nerves, relieving skin inflammation, and fundamentally improving sensitive skin from multiple aspects based on the characteristics of sensitive skin and possible mechanisms;

[0006] 2) The added active ingredients are numerous and complex, which increases the potential safety risks for sensitive skin, reduces the convenience of the production process, and increases unnecessary product costs;

[0007] 3) They are built as drugs or medical devices, focusing only on efficacy, while ignoring the safety of high-frequency use of skin care products and the product characteristics of zero tolerance for side effects;

[0008] 4) Lack of skin feel and fragrance.

[0009] In view of this, the present invention is proposed. Summary of the invention

[0010] The invention discloses a fish scale collagen skin care composition and a fish scale collagen cosmetic and a preparation method thereof. One of the purposes is to provide a skin care composition with a repairing and soothing effect based on the root of sensitive skin problems.

[0011] A second object of the present invention is to provide a cosmetic having the above skin care composition.

[0012] A third object of the present invention is to provide a method for preparing the above-mentioned cosmetic.

[0013] One of the purposes of the present invention is achieved by the following technical solution:

[0014] The present invention discloses a fish scale collagen skin care composition, comprising the following components in parts by weight:

[0015] 0.05-0.5 parts of fish scale collagen, 0.05-0.5 parts of madecassoside, and 0.5-3 parts of purslane extract.

[0016] As a further improvement, the fish scale collagen described in the present invention is derived from sea bass scales, with a molecular weight of 25-150 kDa; and madecassoside is derived from Centella asiatica leaves, with a purity of ≥95%.

[0017] As a further improvement, the skin care composition of the present invention preferably comprises the following components in parts by weight:

[0018] 0.05-0.2 parts of fish scale collagen, 0.05-0.2 parts of madecassoside, and 0.8-2 parts of purslane extract.

[0019] The present invention also discloses a fish scale collagen cosmetic comprising a fish scale collagen skin care composition, comprising the following components in parts by weight: 0.54-4 parts of the skin care composition, 3-6 parts of a moisturizer, 4-9 parts of an emollient, 1-5 parts of an emulsifier, 0.1-0.5 parts of a thickener, 0.01-0.03 parts of a pH adjuster, 0.5-1 parts of a preservative, 0.2-0.5 parts of an antioxidant, and the remainder being purified water.

[0020] As a further improvement, the moisturizing agent of the present invention is glycerol or butylene glycol;

[0021] The emollients are squalane, polydimethylsiloxane, and shea butter, with a mass ratio of 3-6:1-3:2-5;

[0022] The emulsifiers are cetearyl olivate and sorbitan olivate, or polyglyceryl-3 methylglucose distearate.

[0023] As a further improvement, the thickener of the present invention is ammonium acryloyldimethyltaurate / VP copolymer, or polyacrylamide and C13-14 isoparaffin, or hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer;

[0024] The pH adjuster is citric acid or lactic acid.

[0025] As a further improvement, the preservative of the present invention is p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of 0.3-0.6:0.4-0.8, or octanoylhydroxamic acid, phenoxyethanol and o-cymene-5-ol in a mass ratio of 0.03-0.06:0.2-0.3:0.01-0.03;

[0026] The antioxidant is tocopheryl acetate.

[0027] The present invention also discloses a method for preparing fish scale collagen cosmetics, comprising the following steps:

[0028] S1: Mix the moisturizer and purified water, heat and stir evenly to obtain a mixed solution A;

[0029] S2: Mix the emollient, emulsifier and thickener, heat and stir to dissolve, and obtain a mixed solution B;

[0030] S3: adding the mixed solution B to the mixed solution A, stirring and emulsifying, homogenizing until the emulsion is uniform, adding the skin care composition, preservative, and antioxidant after cooling, and stirring evenly to obtain a mixed solution C;

[0031] S4: Add a pH adjuster to the mixed solution C and stir evenly to obtain fish scale collagen cosmetics that have the function of repairing and soothing sensitive skin.

[0032] As a further improvement, in step S1 of the present invention, the heating temperature is 70-85°C.

[0033] As a further improvement, in step S2 of the present invention, the heating temperature is 70-85°C, and in step S3, the cooling temperature is 40-60°C.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] (1) The skin care composition with a repairing and soothing effect of the present invention adopts a combination of fish scale collagen, madecassoside and purslane extract, and repairs the skin barrier, calms and soothes the nerves, relieves skin inflammation based on the characteristics of sensitive skin and possible mechanisms, and improves sensitive skin in multiple ways, rather than treating the symptoms without addressing the root cause. Fish scale collagen, madecassoside and purslane extract have good performance in repairing the skin barrier, calming and soothing the nerves, and relieving skin inflammation. Fish scale collagen has been shown to have good water absorption and moisturizing properties in both high and low humidity environments, and can maintain skin moisture well. It has good free radical scavenging ability, which can reduce the ROS level of oxidatively damaged L929 cells, protect and repair cells, upregulate the expression of type I collagen mRNA, inhibit AP-1 protein expression, reduce collagen degradation, regulate the NF-κB signaling pathway, inhibit inflammation, improve epidermal hyperplasia and collagen fiber reduction; hydroxy-madecassoside is the main active ingredient of Centella asiatica, which has the effects of promoting wound healing, repairing skin scars, anti-allergy, and anti-inflammatory, stimulates the synthesis of type I and III collagen, promotes fibroblast proliferation, and inhibits skin inflammatory reactions caused by the proinflammatory cytokine interleukin-1β; Portulaca oleracea extract reduces inflammatory reactions by inhibiting the release of inflammatory factors and has a good sedative and soothing effect.

[0036] (2) The skin care composition of the present invention has a repairing and soothing effect. The fish scale collagen, madecassoside and purslane extract are respectively derived from the scales of sea bass, Centella asiatica and purslane, which are gifts from nature to mankind, are green and healthy, and can be endowed with high economic value.

[0037] (3) The present invention consolidates the basic condition of sensitive skin and alleviates symptoms such as itching and redness after sensitive skin is stimulated by the synergistic effect of only three simple components and a very small amount of components added. The composition is simple and efficient, and the convenience of the production process is improved.

[0038] (4) The skin care composition of the present application is a cosmetic that can effectively repair the skin barrier, calm and soothe nerves, reduce sensitive phenomena such as skin redness, and is mild and non-irritating to the human body.

[0039] (5) The fish scale collagen cosmetics of the present invention adopt liquid crystal emulsification technology and have a layered structure. The layered structure can slide during application, thereby improving the application feel of the emulsion, and having a good skin feel and fragrance. At the same time, the active ingredients are controlled to be slowly released and help the active ingredients to be gently absorbed by the skin, ensuring that the cosmetics are safe and effective in the short and long term after use. DETAILED DESCRIPTION

[0040] The present invention discloses a fish scale collagen skin care composition and a fish scale collagen cosmetic and a preparation method thereof. First, the fish scale collagen skin care composition comprises the following components in parts by weight:

[0041] 0.05-0.5 parts of fish scale collagen, 0.05-0.5 parts of madecassoside, and 0.5-3 parts of purslane extract. The fish scale collagen is derived from sea bass scales, and has a molecular weight of 25-150 kDa. Madecassoside is derived from Centella asiatica leaves, and has a purity of ≥95%.

[0042] The skin care composition preferably comprises the following components by weight:

[0043] 0.05-0.2 parts of fish scale collagen, 0.05-0.2 parts of madecassoside, and 0.8-2 parts of purslane extract.

[0044] The present invention also discloses a fish scale collagen cosmetic comprising a fish scale collagen skin care composition, comprising the following components in parts by weight: 0.54-4 parts of the skin care composition, 3-6 parts of a moisturizer, 4-9 parts of an emollient, 1-5 parts of an emulsifier, 0.1-0.5 parts of a thickener, 0.01-0.03 parts of a pH adjuster, 0.5-1 parts of a preservative, 0.2-0.5 parts of an antioxidant, and the remainder being purified water.

[0045] Among them, the moisturizer is glycerin or butylene glycol, the emollient is squalane, polydimethylsiloxane, and shea butter, with a mass ratio of 3-6:1-3:2-5; the emulsifier is cetearyl olivate and sorbitan olivate, or polyglyceryl-3 methylglucose distearate; the thickener is ammonium acryloyldimethyltaurate / VP copolymer, or polyacrylamide and C13-14 isoparaffin, or hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer; the pH adjuster is citric acid or lactic acid; the preservative is p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of 0.3-0.6:0.4-0.8, or caprylhydroxamic acid, phenoxyethanol and o-cymene-5-ol in a mass ratio of 0.03-0.06:0.2-0.3:0.01-0.03; the antioxidant is tocopherol acetate.

[0046] The present invention also discloses a method for preparing fish scale collagen cosmetics, comprising the following steps:

[0047] S1: Mix the moisturizer and purified water, heat and stir evenly to obtain a mixed solution A;

[0048] S2: Mix the emollient, emulsifier and thickener, heat and stir to dissolve, and obtain a mixed solution B;

[0049] S3: adding the mixed solution B to the mixed solution A, stirring and emulsifying, homogenizing until the emulsion is uniform, adding the skin care composition, preservative, and antioxidant after cooling, and stirring evenly to obtain a mixed solution C;

[0050] S4: Add a pH adjuster to the mixed solution C and stir evenly to obtain fish scale collagen cosmetics that have the function of repairing and soothing sensitive skin.

[0051] As a further improvement, in step S1 of the present invention, the heating temperature is 70-85°C.

[0052] As a further improvement, in step S2 of the present invention, the heating temperature is 70-85°C, and in step S3, the cooling temperature is 40-60°C.

[0053] In order to better illustrate the purpose, technical solutions and features of the present invention, the present invention is further explained below in conjunction with specific embodiments, but the embodiments do not limit the protection scope of the present invention.

[0054] Unless otherwise specified, the raw materials used in the present invention are all common commercial products and can be purchased from the market.

[0055] The components of the skin care compositions of Examples 1-2 and Comparative Examples 1-3 with repairing and soothing effects are shown in Table 1.

[0056] Table 1 Components of fish scale collagen skin care composition

[0057]

[0058] The preparation method is as follows: prepare the skin care composition according to the components of the embodiment and the comparative example, accurately weigh the raw materials of each component, mix them according to the corresponding proportion, and stir until they are uniform.

[0059] Performance Testing

[0060] 1. Stimulate fibroblast proliferation

[0061] Test method: Select cells in the logarithmic growth phase, collect the cells after trypsin digestion, make a cell suspension, count them with a cell counter, inoculate the cell suspension into two 96-well plates for culture, and after the inoculation, incubate at 37°C, 5% CO2 for 24±2h; discard the culture medium, and carry out drug administration according to the blank control group (containing DMEM culture medium) and the test sample group (DMEM culture medium containing 0.1mg / ml sample concentration), 100μL per well, incubate at 37°C, 5% CO2 for 24h; observe the cell growth status under a biological microscope, and take pictures for record; take out the plate 24±2h after drug administration for MTT test, and measure the absorbance (492nm) of each group.

[0062] Cell proliferation rate = (OD value of test group - average OD value of 24h blank control group) / average OD value of 24h blank control group * 100%

[0063] Test results:

[0064] Table 2 Test results of stimulating fibroblast proliferation

[0065]

[0066] It can be seen from Table 2 that the complex of fish scale collagen, madecassoside and purslane extract is more beneficial to cell proliferation than the complex of single fish scale collagen and madecassoside and purslane extract, which proves that fish scale collagen, madecassoside and purslane extract have a synergistic effect.

[0067] Application Example 1

[0068] This embodiment provides a cosmetic that has the function of repairing, soothing, and is mild (non-irritating) and suitable for sensitive skin, and its components and proportions are shown in Table 3.

[0069] Table 3 Formula of fish scale collagen cosmetic application example 1

[0070]

[0071] The components and proportions of the cosmetics of Comparative Example 1 are shown in Table 4.

[0072] Table 4 Formula of comparative example 1 for fish scale collagen cosmetic application

[0073]

[0074] The preparation method is as follows:

[0075] 1) Add component A to the main pot, heat to 80℃, and stir evenly; 2) Heat component B in an oil pan, heat to 80℃, stir evenly, and keep warm for later use; 3) Pump component B into the main pot, homogenize for 15 minutes, stir evenly, and start cooling; 4) Cool to 45℃, add component C, and stir evenly; 5) Add component D, and stir evenly.

[0076] Efficacy Test

[0077] 1. Stimulate fibroblast proliferation

[0078] Test method: Select cells in the logarithmic growth phase, collect the cells after trypsin digestion, make a cell suspension, count them with a cell counter, inoculate the cell suspension into two 96-well plates for culture, and after the inoculation, incubate at 37°C, 5% CO2 for 24±2h; discard the culture medium, and carry out drug administration according to the blank control group (containing DMEM culture medium) and the test sample group (DMEM culture medium containing 0.2mg / ml sample concentration), 100μL per well, incubate at 37°C, 5% CO2 for 24h; observe the cell growth status under a biological microscope, and take pictures for record; take out the plate 24±2h after drug administration for MTT test, and measure the absorbance (492nm) of each group.

[0079] Cell proliferation rate = (OD value of test group - average OD value of 24h blank control group) / average OD value of 24h blank control group * 100%

[0080] Test results:

[0081] Table 5 Test results of stimulating fibroblast proliferation

[0082]

[0083] It can be seen from Table 5 that the combination of fish scale collagen, hydroxy-madecassoside and purslane extract can promote cell proliferation better than the combination of hydroxy-madecassoside and purslane extract when used in emulsion, and both are better than a certain brand on the market, but the former is more effective than the latter.

[0084] 2. Patch test

[0085] Test method: The selected area should not exceed 50mm 2 , a qualified spot test device with a depth of about 1mm. Add the test substance into the spot tester, with an amount of about 0.020g-0.025g (solid or semi-solid) or 0.020mL-0.025mL (liquid). Apply the spot tester with the test substance and negative control to the curved side of the subject's forearm, and remove the spot tester after 24 hours. Observe the skin reaction according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 edition) 30 minutes (after the indentation disappears), 24 hours and 48 hours after removing the test substance spot tester, and record the observation results.

[0086] Test results:

[0087] Table 6: Statistical table of cosmetic human skin patch test results in Application Example 1

[0088]

[0089] The test results showed that the score of 31 subjects was 0 at 0.5h, 24h and 48h after removing the test patch, indicating no adverse skin reaction.

[0090] 3. Skin stratum corneum moisture content / transepidermal water loss rate TWEL

[0091] Test method: A total of 37 female subjects with sensitive skin aged 24-55 were screened and enrolled. After using the product normally, the moisture content of the stratum corneum of the cheek skin was tested with Corneometer CM 825 on D0 / D14 / D28 respectively; the transepidermal water loss TEWL value of the cheek skin was tested with Tewameter TM Hex on D0 / D14 / D28 respectively.

[0092] Test results:

[0093] Table 7: Test results of moisture content of stratum corneum and transepidermal water loss rate (TWEL) of application example 1

[0094]

[0095] The test results show that compared with before using the samples, the moisture content of the stratum corneum of the 37 subjects was significantly different after using the samples for 14 days, and the TEWL value of the skin was significantly different; after using the samples for 28 days, the moisture content of the stratum corneum of the skin was significantly different, and the TEWL value of the skin was significantly different. This shows that the product has better moisturizing and repairing effects.

[0096] 4. Skin color (red-green) value a* value (VISIA 7+IPP analysis)

[0097] Test method: A total of 37 female subjects aged 24-55 with sensitive skin were screened and enrolled. After using the product normally, the facial image analysis system Visia 7 was used to collect full-face images + IPP analysis on D0 / D14 / D28 respectively.

[0098] Test results:

[0099] Table 8: Test results of skin color (red-green) value a* value of Application Example 1

[0100]

[0101] The test results showed that compared with before using the samples, the skin color (red-green) value a* value of 37 subjects after using the samples for 14 days had a very significant difference; after using the samples for 28 days, the skin color (red-green) value a* value had a very significant difference. This shows that the product has a soothing effect.

[0102] 5. Lactic acid sting assessment

[0103] Test method: Take 50 μL of 10% lactic acid solution and drop it on a single layer of non-woven fabric with a diameter of 0.8 cm. Apply the non-woven fabric to the nasolabial groove on either side of the subject, and use distilled water as a control on the other side. The researcher asked the subject about the tingling sensation at 0.5min, 2.5min, 5min and 8min, and scored it according to the "4-point method" for lactic acid tingling.

[0104] Test results:

[0105] Table 9: Test results of lactic acid stinging score value of Application Example 1

[0106]

[0107] The test results showed that compared with before using the sample, the lactic acid stinging score of 37 subjects after using the sample for 14 days was significantly different; after using it for 28 days, the lactic acid stinging score was significantly different, indicating that the product has a soothing effect.

[0108] 6. Self-evaluation by the subjects

[0109] Test method: A total of 37 female subjects with sensitive skin aged 24-55 were screened and enrolled. After using the product normally, questionnaires were conducted 5 minutes, 14 days and 28 days after use to evaluate their feelings after use.

[0110] Scoring criteria: (5-point system) 1 point for strongly disagree, 2 points for disagree, 3 points for neither agree nor disagree, 4 points for agree, and 5 points for strongly agree.

[0111] Test results:

[0112] Table 10 Self-evaluation results of subjects in Application Example 1

[0113]

[0114] The test results show that the vast majority of subjects agree that this product has a pleasant smell, is easy to apply and absorb, and feels soft and non-greasy; all subjects agree that this product is suitable for sensitive skin, is gentle and non-irritating, and has significant moisturizing, repairing, and soothing effects.

[0115] 7. Product stability test

[0116] The cosmetics prepared by Application Example 1 and Application Comparative Example 1 were subjected to stability tests such as heat resistance, cold resistance, and light resistance, wherein:

[0117] Heat resistance test conditions: 45±2℃, 3 months;

[0118] Cold resistance test conditions: -8±2℃, 1 month;

[0119] The variable temperature test conditions are: -5±2℃ 24h to 40±2℃ 24h, cycle for 1 month;

[0120] The lighting test conditions are: 4500±500lx, 25±2℃, 1 month.

[0121] Test results:

[0122] Table 11 Stability test results

[0123]

[0124] The cosmetics of the present invention have no abnormalities in viscosity, pH, appearance, and fragrance under different conditions of heat resistance, cold resistance, temperature changes, and light, indicating that the cosmetics provided in this application have excellent stability.

[0125] In summary, the cosmetic provided by the present application contains a composition of fish scale collagen, madecassoside and purslane extract, which can enhance the skin barrier, soothe skin redness, improve the irritation state of sensitive skin, and is gentle and non-irritating. The combination of fish scale collagen, madecassoside and purslane extract at a low addition amount can significantly promote cell proliferation, repair skin, and show a good synergistic effect.

[0126] All the above specific embodiments are only part of the implementation schemes of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field within the technical scope disclosed by the present invention, and any equivalent replacement or change made by the technicians in this technical field according to the technical scheme and inventive concept of the present invention should be included in the protection scope of the present invention.

Claims

1. A fish scale collagen skin care composition, characterized in that: The composition includes the following components by weight: 0.05-0.5 parts of fish scale collagen, 0.05-0.5 parts of madecassoside, and 0.5-3 parts of purslane extract.

2. The fish scale collagen skin care composition according to claim 1, characterized in that: The fish scale collagen is derived from sea bass scales, with a molecular weight of 25-150 kDa; the madecassoside is derived from Centella asiatica leaves, with a purity of ≥95%.

3. The fish scale collagen skin care composition according to claim 1, characterized in that: The skin care composition preferably has the following components by weight: 0.05-0.2 parts of fish scale collagen, 0.05-0.2 parts of madecassoside, and 0.8-2 parts of purslane extract.

4. A fish scale collagen cosmetic comprising the fish scale collagen skin care composition according to claim 1, 2 or 3, characterized in that: The invention comprises the following components in parts by weight: 0.54-4 parts of skin care composition, 3-6 parts of moisturizing agent, 4-9 parts of emollient, 1-5 parts of emulsifier, 0.1-0.5 parts of thickener, 0.01-0.03 parts of pH adjusting agent, 0.5-1 parts of preservative, 0.2-0.5 parts of antioxidant, and the rest is purified water.

5. The fish scale collagen cosmetic according to claim 4, characterized in that: The moisturizing agent is glycerin or butylene glycol; The emollients are squalane, polydimethylsiloxane, and shea butter in a mass ratio of 3-6:1-3:2-5; The emulsifier is cetearyl olivate and sorbitan olivate, or polyglyceryl-3 methylglucose distearate.

6. The fish scale collagen cosmetic according to claim 5, characterized in that: The thickener is ammonium acryloyldimethyltaurate / VP copolymer, or polyacrylamide and C13-14 isoparaffin, or hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer; The pH adjuster is citric acid or lactic acid.

7. The fish scale collagen cosmetic according to claim 4, characterized in that: The preservative is p-hydroxyacetophenone and 1,2-hexanediol in a mass ratio of 0.3-0.6:0.4-0.8, or octanoylhydroxamic acid, phenoxyethanol and o-cymene-5-ol in a mass ratio of 0.03-0.06:0.2-0.3:0.01-0.03; The antioxidant is tocopherol acetate.

8. A method for preparing fish scale collagen cosmetics according to any one of claims 5 to 7, characterized in that: The following steps are involved: S1: Mix the moisturizer and purified water, heat and stir evenly to obtain a mixed solution A; S2: Mix the emollient, emulsifier and thickener, heat and stir to dissolve, and obtain a mixed solution B; S3: adding the mixed solution B to the mixed solution A, stirring and emulsifying, homogenizing until the emulsion is uniform, adding the skin care composition, preservative, and antioxidant after cooling, and stirring evenly to obtain a mixed solution C; S4: Add a pH adjuster to the mixed solution C and stir evenly to obtain fish scale collagen cosmetics with the function of repairing and soothing sensitive skin.

9. The method for preparing fish scale collagen cosmetics according to claim 8, characterized in that: In step S1, the heating temperature is 70-85°C.

10. The method for preparing fish scale collagen cosmetics according to claim 8, characterized in that: In step S2, the heating temperature is 70-85°C, and in step S3, the cooling temperature is 40-60°C.

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