Use of kerato cell growth factor-2 in treatment of chronic cervicitis medicine

A technology of chronic cervicitis and keratinocytes, which is applied in the field of keratinocyte growth factor-2 as a drug for the preparation of chronic cervicitis, which can solve the problems of patients’ daily life inconvenience, adverse reactions, and long healing time, so as to achieve no sequelae and good effect Good, simple and easy production process

Inactive Publication Date: 2007-01-17
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various physical treatments are often used clinically, such as freezing, electric ironing, laser, infrared rays, etc., to destroy the columnar epithelium on the erosive surface of the cervix, make it necrotic and fall off, and be covered by new squamous epithelium, but there are postoperative bleeding and infection. , long healing time, the possibility of infertility caused by cervical stenosis, and many adverse reactions to vaginal delivery, and it also brings a lot of inconvenience to patients' daily life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Recombinant human keratinocyte growth factor-2 or human keratinocyte growth factor-2 (KGF-2) is used to prepare vaginal suppositories for treating chronic cervicitis. Formula: KGF-2 0.4g, glycerin 120g, gelatin 40g, mannitol 4g, phosphate 10g, human albumin 2g. Preparation method: Weigh 40g of prescription gelatin, add the same amount of pure water, soak for 1 hour, heat and dissolve in a water bath, then add 120g of glycerin, stir, evaporate excess water to reduce weight to 180g, add 4g of mannitol, human blood white 2g of protein, 10g of phosphate, stir well, keep the temperature at 37°C-40°C, add 0.4g of KGF-2, stir well, pour into the mold, cool naturally, cut off the overflow part of the mold mouth, demould, and seal.

Embodiment 2

[0018] Example 2: KGF-2 is used to prepare vaginal effervescent tablets for treating chronic cervicitis. Formula: KGF-20.4g, glycerin 0.6g, citric acid 10g, sodium bicarbonate 8g, lactose 20g, PEG-6000 2g. Preparation method: Divide lactose into two parts, one part is mixed with KGF-2, glycerin, citric acid, the other part is mixed with sodium bicarbonate, granulated with 5% PVP absolute ethanol as binder, 40 °C After drying, granulate, add PEG-6000, mix well, and press into tablets.

Embodiment 3

[0019] Example 3: KGF-2 is used to prepare vaginal gel for treating chronic cervicitis. Recipe: KGF-2 2g Carbomer 940 12g, glycerin 50g, propylparaben 1g, triethanolamine 1.5g, pure water to 1000g. Preparation method: Sprinkle carbomer into an appropriate amount of pure water, stir well to make swelling and disperse evenly, add KGF-2, glycerin and propyl p-hydroxybenzoate respectively, mix and stir evenly with carbomer solution, add triethanolamine Adjust the pH to transparent and viscous, and finally add pure water to a sufficient amount, and pack it separately.

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Abstract

An application of the horny cell growing factor-2 in preparing the medicine in the form of vaginal suppository, effervescent tablet, gel, etc for treating chronic cervcitis is disclosed.

Description

technical field [0001] The present invention relates to the use in the field of pharmacy, more specifically to the use of Keratinocyte growth factor-2 (Keratinocyte growth factor-2, KGF-2) as a medicine for treating chronic cervicitis. Background technique [0002] Keratinocyte growth factor-2 (Keratinocyte growth factor-2, KGF-2), also known as fibroblast growth factor-10 (fibroblast growth factor-10, FGF-10), is a member of the FGF family. It is secreted by fibroblasts and other mesenchymal cells, the specific target cells are various epithelial cells, and the specific receptors are tyrosine kinase receptors FGFR2 IIIb (KGFR) and FGFR1 IIIb, mainly responsible for mesenchymal cells-epithelial cells It is a cytokine that regulates the mesenchymal-epithelial interaction. KGF-2 specifically promotes the proliferation, differentiation and migration of epithelial cells, and is an important multifunctional signaling molecule in the development of embryo...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P15/00
Inventor 杨静尹龙武李颖夏雪雁彭仁琇敖英孔锐
Owner WUHAN UNIV
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