12 results about "Aconitum pendulum" patented technology

The invention discloses a preparation method and application of a Tibetan medicine Qipeng pill. The Qipeng pill comprises Tibetan medicine active components and microcrystalline fibers, the microcrystalline fibers account for 30% of the weight of pellets, and the method comprises the following steps: uniformly mixing the active components and the microcrystalline fibers to obtain a mixture, adding 75% ethanol to prepare a soft material, filling the soft material into an extruder, extruding the soft material into strip columns, cutting the strip columns in a rolling machine, rolling the strip columns into pellets with uniform sizes, drying and sieving to obtain the Qipeng pill. Wherein the active component is prepared from fine powder of seven raw materials including fructus chebulae (denucleated), radix aconiti lateralis preparata, radix aucklandiae, rhizoma acori calami, Muslim myrrh, calculus bovis factitius and artificial musk. The Qipeng pill prepared by the method is good in roundness, good in friability, high in yield and uniform in size. In addition, the Qipeng pill also has the prospect of treating acute lung injury.

The invention belongs to the technical field of traditional Chinese medicine (Tibetan medicine), and particularly relates to a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The invention discloses a Tibetan medicine composition for treating new coronavirus infection and application of the Tibetan medicine composition. The composition is prepared from the following components in parts by weight: 100 to 700 parts of fructus chebulae, 10 to 80 parts of radix aconiti lateralis, 10 to 60 parts of radix aucklandiae, 50 to 600 parts of rhizoma acori calami, 10 to 50 parts of Muslim myrrh, 0.01 to 50 parts of calculus bovis factitius and 0.01 to 50 parts of artificial musk. The composition can inhibit the mRNA expression of the N gene and the ORF1ab gene after the SARS-CoV-2 virus infects the Vero cell, so that the treatment on the novel coronavirus infection is realized.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition, its preparation method, and its uses. By mass parts, the raw materials of the traditional Chinese medicine composition include: 20-60 parts of Acorus calamus, 30-50 parts of Citrus aurantium, 20-60 parts of Benzoin, and 40-100 parts of Catechu. The traditional Chinese medicine composition of this invention has simple and natural components, and clear efficacy. It can effectively reduce the levels of XOD, SUA, CRE, BUN, TNF-α, IL-6, D-Lac, and DAO in the serum of a mouse model of gout, and significantly reduce the renal index, demonstrating good efficacy in treating hyperuricemia and / or gout.

The invention relates to the technical field of animal medicines, and particularly discloses a veterinary medicine compound preparation as well as a preparation method and application thereof. The veterinary medicine compound preparation is prepared by boiling, extracting, concentrating and diluting eight Tibetan medicines including aconitum pendulum, fructus chebulae, radix inulae inula, benzoin, pterocephalus hookeri, lagotis lagotis, amomum tsao-ko and rhodiola rosea. The veterinary drug compound preparation provided by the invention has an antibacterial range of 8.67 mm to 23.77 mm on enterotoxic large intestine dried bacteria, salmonella enteritidis and pasteurella multocida, and has an inhibition rate of 60% to 72% on enterotoxigenic escherichia coli diarrhea, salmonella enteritidis diarrhea and pasteurella multocida diarrhea; therefore, the veterinary drug compound preparation provided by the invention has a remarkable inhibition effect on enterotoxic large intestine dry bacteria, salmonella enteritidis and pasteurella multocida.

Provided are a traditional Chinese medicine composition for treating cardiorenal syndrome and cardiac failure and a method for preparing same. The traditional Chinese medicine composition is prepared from the following raw materials: 3 to 20 parts of Cinnamomi ramulus, 3 to 25 parts of Atractylodis macrocephalae rhizoma, 3 to 25 parts of Jujubae fructus, 6 to 45 parts of Astragali radix, 2 to 20 parts of Panacis majoris rhizoma, 3 to 30 parts of Paeoniae rubra radix, 6 to 25 parts of Spatholobi caulis, 6 to 25 parts of Ginkgo folium, 6 to 35 parts of Poria, 3 to 20 parts of Zingiberis rhizoma recens, 2 to 25 parts of Citri fructus, 2 to 15 parts of Nigellae semen, 2 to 20 parts of Inulae flos, and 3 to 25 parts of Alismatis rhizoma.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 20 to 60 parts of rhizoma acori calami, 30 to 50 parts of radix aconiti lateralis, 20 to 60 parts of benzoin and 40 to 100 parts of catechu. The traditional Chinese medicine composition disclosed by the invention is simple and natural in component and clear in drug effect, can effectively reduce the contents of XOD, SUA, CRE, BUN, TNF-alpha, IL-6, D-Lac and DAO in serum of a gout mouse model, remarkably reduces the kidney index, and has a good drug effect on treating hyperuricemia and / or gout.

The invention discloses a Tibetan medicine plaster formula for treating pain, and relates to the technical field of traditional Chinese medicines, and the Tibetan medicine plaster formula is prepared from the following active raw materials in parts by weight: 10-20 parts of lamiophlomis rotata, 5-10 parts of rhodiola rosea, 15-20 parts of paris polyphylla, 3-10 parts of lemonfragrant angelica root and 10-20 parts of aconitum pendulum. Through the synergistic effect of lamiophlomis rotata, aconitum pendulum and paris polyphylla in a specific ratio, the effects of promoting blood circulation to remove blood stasis and calming and relieving pain are remarkably enhanced, and meanwhile, the qi-tonifying and collateral-dredging component of rhodiola rosea can improve local microcirculation so as to promote medicine permeation and pain area repair; and the lemonfragrant angelica root is used as a channel guiding medicine to effectively improve the transdermal absorption rate of the medicinal components.

The invention relates to the technical field of animal medicines, and particularly discloses a veterinary medicine compound preparation as well as a preparation method and application thereof. The veterinary medicine compound preparation is prepared by boiling, extracting, concentrating and diluting eight Tibetan medicines including aconitum pendulum, fructus chebulae, radix inulae inula, benzoin, pterocephalus hookeri, lagotis lagotis, amomum tsao-ko and rhodiola rosea. The veterinary drug compound preparation provided by the invention has an antibacterial range of 8.67 mm to 23.77 mm on enterotoxic large intestine dried bacteria, salmonella enteritidis and pasteurella multocida, and has an inhibition rate of 60% to 72% on enterotoxigenic escherichia coli diarrhea, salmonella enteritidis diarrhea and pasteurella multocida diarrhea; therefore, the veterinary drug compound preparation provided by the invention has a remarkable inhibition effect on enterotoxic large intestine dry bacteria, salmonella enteritidis and pasteurella multocida.

The application provides a production process of Panlongqi tablets and relates to the fields of traditional Chinese medicine compositions and traditional Chinese medicine preparations. The production process comprises the following steps: grinding and screening Radix Aconiti Lateralis, Radix Aconiti Kusnezoffii and Radix Aconiti Praeparatae, adding 12-14 times of water, soaking for 25-35 min, decocting for 2-3 h, adding 8-10 times of water for the second time, decocting for 1-2 h, adding 4-5 times of water for the third time, decocting for 1-2 h, filtering, and concentrating to obtain extract; grinding and screening the remaining medicinal materials to obtain coarse materials; activating and drying the coarse materials; adding a composite enzyme, adjusting pH, ultrasonic extraction, and vacuum reducing pressure concentration to obtain extract; refining the extract by using a macroporous adsorption resin column chromatography; adding mannitol, isomalt, tert-butylhydroquinone and magnesium stearate, spray drying, tabletting, sugar coating, and obtaining Panlongqi tablets. The Panlongqi tablets prepared by the application have the effects of activating blood and resolving stasis, dispelling wind and dampness, and relieving swelling and pain, and have very high stability, and are suitable for industrial popularization.

The invention relates to the technical field of traditional Chinese medicine analysis and traditional Chinese medicine quality control, in particular to a method for analyzing the chemical component difference of aconitum pendulum and a child excrement product thereof based on a UPLC-Q-TOF-MS-MS (Ultra Performance Liquid Chromatography-Quality Time of Flight Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass Spectrometry-Mass analyzing chemical components in the sample; performing principal component analysis and orthogonal partial least squares discriminant analysis on the mass spectrum data by using SPSS software, and comparing the difference of chemical components of the aconitum pendulum and the processed products of the defecate of the aconitum pendulum from different producing areas; according to the invention, through comprehensive analysis of chemical components of the crude aconitum pendulum and the processed children's excrement product, a scientific research on a material basis is further laid for revealing the medicine effect enhancement of the processing of the aconitum pendulum prepared from children's excrement, and meanwhile, the research result shows that the Tibetan medicine strictly complies with the processing procedure in clinical application of the aconitum pendulum; meanwhile, an important basis needs to be provided for achieving the purpose of reducing toxicity by paying attention to reasonable compatibility of medicinal materials.

The invention relates to the technical field of Tibetan medicines, and discloses a Tibetan medicine formula, a Tibetan medicine emplastrum and a preparation method of the Tibetan medicine emplastrum. The formula comprises 30 to 50 parts of Tibetan cat milk, 30 to 50 parts of aconitum pendulum, 15 to 30 parts of acorus calamus, 8 to 15 parts of Muslim myrrh, 8 to 15 parts of frankincense, 8 to 15 parts of cassia seed, 8 to 15 parts of abelmoschus esculentus seed, 20 to 40 parts of myristica fragrans, 8 to 15 parts of delphinium delphinium, 30 to 50 parts of common vladimiria root and 30 to 50 parts of fructus chebulae, and an ointment-containing body layer of the emplastrum comprises the Tibetan medicine formula provided by the invention. The prescription provided by the invention is guided by a prescription solution of a Tibetan medicine classic famous prescription 'Ruyi treasure prescription', simplifies the medicinal composition, neutralizes the toxicity of medicinal materials, not only improves the safety, but also expands the range of indications and improves the curative effect, and the Tibetan medicine prescription external dosage form emplastrum provided by the invention has the characteristics of simplicity, portability, convenience in use, high patient compliance and the like.

This invention belongs to the field of biotechnology, providing a VIGS silencing system for the AgPDS gene in *Aconitum carmichaelii*, its construction method, and its application. It is a method for constructing a transient gene silencing system for *Aconitum carmichaelii* based on VIGS technology, and the constructed silencing system has been validated through application. The results show that this silencing system can significantly reduce the expression level of the AgPDS gene in *Aconitum carmichaelii* leaves, with a plant silencing rate of 70.83%. This invention utilizes a combination of leaf injection and soil drenching infection methods. The *Aconitum carmichaelii* AgPDS gene silencing system constructed using tobacco brittle virus (TRV) can be systematically disseminated within *Aconitum carmichaelii* plants, effectively reducing the expression level of the *Aconitum carmichaelii* AgPDS gene, resulting in chlorophyll bleaching. The gene silencing system of this invention is simple, rapid, and efficient, providing strong support for the biosynthesis analysis of medicinal components in *Aconitum* plants and related research on molecular breeding for genetic improvement.