Alkaloid microcapsule and preparation method thereof

An alkaloid and microcapsule technology, applied in the fields of botanical equipment and methods, biocides, animal repellents, etc., can solve the problems of poor palatability, anti-feeding, and short duration of drug effect of alkaloids, and achieve reduced acute toxicity, The effect of prolonging the efficacy time and improving the stability

An alkaloid and microcapsule technology, applied in the fields of botanical equipment and methods, biocides, animal repellents, etc., can solve the problems of poor palatability, anti-feeding, and short duration of drug effect of alkaloids, and achieve reduced acute toxicity, The effect of prolonging the efficacy time and improving the stability

CN104472479AInactive Publication Date: 2015-04-01LANZHOU UNIVERSITY
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  • Alkaloid microcapsule and preparation method thereof
  • Alkaloid microcapsule and preparation method thereof

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Experimental program
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Embodiment

[0021] S1: Alkaloid extraction

[0022] After mechanically pulverizing the plant sample, weigh an appropriate powder, put it in a beaker, add 2 times the volume of 95% ethanol, soak overnight, extract at 40°C with ultrasonic waves for 30 minutes, vacuum filter with a Buchner funnel, and remove the ethanol by rotary evaporation of the filtrate. The remaining solid was extracted and concentrated three times in total.

[0023] The resulting solid was suspended in distilled water, and acidified to pH=2-3 by adding 2% hydrochloric acid solution. The aqueous phase was extracted three times with 15% dichloromethane by volume, and the organic dichloromethane phase was discarded. The aqueous phase was adjusted to pH = 9-10 with 28% ammonia water, extracted three times with dichloromethane having an equal volume to water, and the combined organic phases were collected. The dichloromethane was removed by rotary evaporation to obtain the total alkaloids.

[0024] S2: Preparation of alk...

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Abstract

The invention relates to an alkaloid microcapsule and a preparation method thereof. The alkaloid microcapsule comprises a capsule core and a capsule wall, wherein the capsule core comprises one or more alkaloids extracted from aconite, aconitum pendulum, mandala, black false hellebore, radix sophorae flavescentis and semen strychni; the capsule wall comprises polyurea which is prepared from polyamine and polyisocyanate. The bitter taste of the alkaloid is covered by microcapsule coating, and the stability of the alkaloid is certainly improved. The alkaloid inside the microcapsule can be slowly released for a long time by the effect of the external environment, so the medicinal effect time is prolonged; the acute toxicity of the alkaloid is certainly alleviated and the alkaloid is chronic in toxicity; on one hand, the vigilance of insects can be reduced; on the other hand, harms to beneficial organisms and humans can be reduced, so the alkaloid microcapsule belongs to an environment-friendly pesticide.

Description

technical field [0001] The invention relates to the fields of pesticides and medicines, in particular to an alkaloid microcapsule and a preparation method thereof. Background technique [0002] Alkaloids are a class of basic compounds containing nitrogen atoms, which mainly exist in higher plants in nature. There are many kinds of known alkaloids with complex structures. Most alkaloids are colorless solids with a bitter taste. The water solubility of alkaloids is generally poor, but they are easily soluble in organic solvents such as ether, chloroform, methylene chloride, etc. The salts formed by the reaction of alkaloids and acids are usually easily soluble in water, so the extraction of alkaloids is usually carried out using acid-base Adjust the extraction method. [0003] Most alkaloids have pharmacological effects or toxicity to animals and can therefore be used as drugs, such as caffeine and nicotine as stimulants, morphine and codeine as analgesics, quinine as antim...

Claims

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Application Information

Patent Timeline
01 Apr 2015
Publication
CN104472479A
IPC
A01N25/28; A01N65/20; A01N65/08; A01N65/42; A01N65/32; A01P7/04
Inventors
王静; 胡开明