Application of indole-2, 3-diketone in preparing antimycotics medicament

An antifungal drug, indole technology, applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low specificity of antifungal drugs, high toxicity, waste of manpower and financial resources, etc.

Inactive Publication Date: 2008-07-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there are adverse factors such as low specificity, high toxicity, and easy drug resistance of existing antifungal drugs, which not only reduces the quality of life of patients, but also wastes a lot of manpower and financial resources.
Although the effect of western antifungal drugs is remarkable, most of them are expensive and highly toxic. Therefore, finding natural antifungal drugs with broad spectrum and less toxic and side effects in traditional plants and marine substances is the common focus of medical workers.

Method used

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  • Application of indole-2, 3-diketone in preparing antimycotics medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of preparation

[0018] Tablet preparation

[0019] Indole-2,3-dione 100mg

[0020] Lactose 100mg

[0021] Starch 295mg

[0022] Magnesium Stearate 5mg

[0023] Total 500mg

[0024] Weigh out the above-mentioned ingredients respectively, mix the indole-2,3-dione crystals and crush the powder, lactose, and starch through an 80-mesh sieve, granulate by wet method, dry, mix with magnesium stearate after integration, and press Tablets made into tablets with a weight of 500 mg each.

[0025] Preparation of capsules

[0026] Indole-2,3-dione 100mg

[0027] Starch 395mg

[0028] Magnesium Stearate 5mg

[0029] Total 500mg

[0030] Each of the above-mentioned ingredients was weighed out, mixed evenly with indole-2,3-dione crystalline powder passed through a 80-mesh sieve, carefully filled into capsules, and made into capsules each with a net weight of 500 mg.

[0031] Preparation of cream

[0032] Indole-2,3-dione 1g

[0033] Cream bas...

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Abstract

The present invention relates to an application of indole-2, 3-dione for preparing for an antifungal drug. The indole-2, 3-dione is natural product or manual synthetical product with low toxicity, little side effect and good antifungal effect.

Description

technical field [0001] The invention relates to the application of indole-2, 3-dione (MW147, indole-2, 3-dione) in the preparation of antifungal drugs. Background technique [0002] At present, the extensive application and abuse of broad-spectrum antibiotics, immunosuppressants and glucocorticoids, especially in the case of frequent occurrence of epidemic diseases such as influenza, AIDS, SARS, bird flu, etc., the patient's immunity is reduced, leading to fungal infections rate increases year by year. Moreover, there are adverse factors such as low specificity, high toxicity, and easy drug resistance of antifungal drugs, which not only reduce the quality of life of patients, but also waste a lot of manpower and financial resources. Although western antifungal drugs have remarkable effects, most of them are expensive and highly toxic. Therefore, finding natural antifungal drugs with broad spectrum and low toxic and side effects from traditional plants and marine substances ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K9/20A61K9/48A61P31/10
Inventor 岳旺张丽周三于兹东黄霞
Owner QINGDAO UNIV
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