A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same

A niclosamide ethanolamine salt, nano-suspension technology, applied in the directions of botanical equipment and methods, biocides, biocides, etc. Non-uniformity and other problems, to achieve the effect of improving bioavailability, reducing drug dosage, and weakening acute toxicity

Inactive Publication Date: 2006-12-27
JIANGSU INST OF PARASITIC DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the unsatisfactory solubility and dispersibility of various powders of niclosamide, small lumps of precipitates are easy to block the spraying equipment, resulting in difficulty in use and uneven concentration of the liquid solution, resulting in a decline in the molluscicide effect

Method used

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  • A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same
  • A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Preparation of stock solution of niclosamide ethanolamine salt nano-suspension

[0019] In terms of mass percentage, 25% of niclosamide ethanolamine salt and 5% polyoxyethylene are added to 70% dimethyl sulfoxide, stirred and dissolved to obtain a stock solution of niclosamide ethanolamine salt nano suspension.

Embodiment 2

[0020] Embodiment 2: Preparation of the stock solution of niclosamide ethanolamine salt nano-suspension

[0021] In terms of mass percentage, 5% of niclosamide ethanolamine salt and 1% sodium polyphosphate are added into 94% dimethyl sulfoxide, stirred and dissolved to obtain a stock solution of niclosamide ethanolamine salt nano-suspension agent.

Embodiment 3

[0022] Embodiment 3: Preparation of the stock solution of niclosamide ethanolamine salt nano-suspension

[0023] In terms of mass percentage, 15% of niclosamide ethanolamine salt and 10% of polyvinylpyrrolidone are added to 75% of dimethyl sulfoxide, stirred and dissolved to obtain a stock solution of niclosamide ethanolamine salt nano-suspension agent.

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Abstract

The invention relates to niclosamide ethanolamine salt nano suspending agent for killing oncomelania and its preparation method, belongs to oncomelania-killing drug and insoluble drug nano preparation technology field. The method comprises steps of adding dimethyl sulphoxide to stablizer 1%-10% in mass content and niclosamide ethanolamine salt 5%-25% in mass content and mixing ,confecting solution, obtaining niclosamide ethanolamine salt nano suspending agent stock solution, adding it to aqueous solution when stirring niclosamide ethanolamine salt content being 0.01%-1%, niclosamide ethanolamine salt grain size being 50nm-1 mum, obtaining niclosamide ethanolamine salt nano suspending agent. The inventive method can make water-insoluble niclosamide ethanolamine salt disperse well in waterbody. The solution can be used while being prepared. The inventive niclosamide ethanolamine salt nano suspending agent is simply prepared, and promote bioavailability while meet the need of killing snail and reduce the toxicity to fish.

Description

technical field [0001] The invention discloses a nano-suspension agent of niclosamide ethanolamine salt, a snail-killing drug, and a preparation method thereof, belonging to the technical field of nano-preparation of snail-killing drugs and insoluble drugs. Background technique [0002] With the development of nanotechnology, the nanotechnology of poorly soluble drugs is an important way to research and develop high-efficiency preparations. The nano-preparation of insoluble drugs has a large surface area and a high degree of dispersion, which can improve the solubility of the drug, make the drug more easily absorbed by the organism, and better exert the drug effect; secondly, due to its small particle size, the nano-particles are easier to penetrate Through the epidermis and biofilm in the body, it is convenient to enter the focus of the organism and improve the bioavailability of the drug; at the same time, the combination of nanoparticles and carriers can also better solve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/48A01N25/22A01P9/00
Inventor 朱荫昌李新松戴建荣姜柳梁幼生
Owner JIANGSU INST OF PARASITIC DISEASES
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