Medicament for preventing and controlling rodent damage and preparation method thereof

A technology of medicament and rodent damage, which is applied in the field of medicament and its preparation for preventing rodent damage, and can solve problems such as secondary poisoning, endangering livestock and human health, and reducing natural enemies of rodents.

Inactive Publication Date: 2016-05-11
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional rodent control mainly uses chemical drugs to eliminate rodents. This method has a fast effect and a large area, and can temporarily reduce the density of rodents. However, these chemical drugs can cause secondary poisoning, resulting in the reduction of rodent natural enemies, and the ecological balance is affected. Damage, improper use will pollute the environment, endanger the health of domestic animals and humans

Method used

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  • Medicament for preventing and controlling rodent damage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Preparation of aqueous phase solution: dissolve the dispersant polyvinyl alcohol (molecular weight 70,000-80,000) in distilled water, heat and dissolve, and prepare a 2% colloidal solution, add emulsifier Tween 80 to the dispersant solution, and prepare into a 0.5% solution, stirred and dissolved for 5 minutes, and cooled to 50°C.

[0027] 2) Preparation of organic phase solution: 1.0 ml of toluene diisocyanate was dissolved in 5 ml of chloroform, and 0.02 g of alkaloid was added.

[0028] 3) Preparation of water-phase monomer: 1.0 ml of diethylenetriamine was dissolved in 5 ml of distilled water, and sucked into a needle for use.

[0029] 4) Reaction procedure, put the reaction container three-neck glass flask in a 50°C water bath, add the organic phase solution to the water phase solution under mechanical stirring, and stir for 10 minutes. After the solution state is stable, add the water phase monomer dropwise with a needle tube , the dropping speed is 1 drop / s, ...

Embodiment 2

[0035] The preparation of alkaloid microcapsules follows the steps below:

[0036] 1) Preparation of aqueous phase solution: dissolving polyvinyl alcohol (molecular weight 70,000-80,000) in distilled water, heating and dissolving, and preparing 4% colloidal solution. Add emulsifier sodium dodecylsulfonate to the dispersant solution to prepare a 0.5% solution, stir and dissolve for 5 minutes, then cool to 45°C.

[0037] 2) Preparation of organic phase solution: 1.0 ml of diphenylmethane diisocyanate was dissolved in 10 ml of dichloromethane, and 0.05 g of alkaloid was added.

[0038] 3) Preparation of water-phase monomer: Dissolve 1.5ml of ethylenediamine in 5-10ml of distilled water, and inhale into a needle for use.

[0039] 4) Reaction procedure: put the reaction container three-neck glass flask in a 45°C water bath, add the organic phase solution to the water phase solution under mechanical stirring, and stir for 10 minutes. After the solution is stable, add the water phas...

Embodiment 3

[0045] 1) Preparation of aqueous phase solution: dissolve the dispersant polyvinyl alcohol (molecular weight 70,000-80,000) in distilled water, heat to dissolve, and prepare a 5% colloidal solution, add emulsifier dodecylbenzene to the dispersant solution Sodium sulfonate was formulated into a 0.5% solution, stirred and dissolved for 5 minutes, and then cooled to 60°C.

[0046] 2) Preparation of organic phase solution: 1.0 ml of toluene diisocyanate was dissolved in 5 ml of chloroform, and 0.02 g of alkaloid was added.

[0047] 3) Preparation of water-phase monomer: 1.0 ml of diethylenetriamine was dissolved in 5 ml of distilled water, and sucked into a needle for use.

[0048]4) Reaction procedure, put the reaction container three-necked glass flask in a 50°C water bath, add the organic phase solution to the water phase solution under mechanical stirring, and stir for 10 minutes. After the solution is stable, add the water phase monomer dropwise with a needle tube , the drop...

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PUM

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Abstract

The invention relates to a medicament capable of preventing and treating damages caused by rat and a preparation method of the medicament. The medicament comprises the following components in parts by weight: 1-10 parts of alkaloid microcapsules and 90-99 parts of auxiliary materials, wherein a capsule core of the alkaloid microcapsule comprises one or more of alkaloids extracted from wild aconite root, root of pendulous monkshood, datura stramonium, black false hellebore, lightyellow sophora root and nux vomica; and the capsule walls of the alkaloid microcapsules comprise polyurea prepared from polyamine and polyisocyanate. The alkaloid is covered by the alkaloid microcapsules so that the palatability is obviously improved and the speed of oxidizing and degrading the alkaloid in the environment is reduced. The swallowed alkaloid microcapsules can be slowly released in rats and the acute toxicity of the medicament is reduced; and the medicament mainly has chronic toxicity so that the alertness of the rats can be reduced and the damages to human and livestock, and rat natural enemies are alleviated.

Description

technical field [0001] The invention relates to the field of rodent damage prevention and control, in particular to a medicament for preventing rodent damage and a preparation method thereof. Background technique [0002] The large-scale reproduction and frequent activities of rodents will cause serious ecological problems. They steal food, eat grass roots and tree roots, dig holes, and seriously endanger the production of agriculture and forestry. In areas where humans are active, rodents can transmit various diseases to humans and domestic animals through various channels. In human history, plague outbreaks have caused tens of millions of deaths. Therefore, the prevention and control of rodent damage is very necessary. Traditional rodent control mainly uses chemical drugs to eliminate rodents. This method has a fast effect and a large area, and can temporarily reduce the density of rodents. However, these chemical drugs can cause secondary poisoning, resulting in the redu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/28A01N65/42A01N65/38A01N65/32A01N65/08A01N65/20A01P11/00
Inventor 王静胡开明傅华张卫国
Owner LANZHOU UNIVERSITY
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