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Method for analyzing maximum no-effect concentration of chemical acting on organisms

An analysis method and chemical technology, applied in the field of pesticide data analysis, can solve the problems of lack of consideration of data properties, inability to guarantee the accuracy of statistical analysis energy efficiency and results, simplicity and roughness, etc., to achieve the effect of ensuring energy efficiency and accuracy of analysis

Active Publication Date: 2020-08-11
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above methods are either simple and rough, or lack of consideration of the nature of the data, ignoring the requirements of data type, monotonicity, normality and homogeneity of variance on the applicability of the analysis method, blindly applying the parametric statistical method, cannot guarantee the energy efficiency of the statistical analysis and the accuracy of the results. precise

Method used

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  • Method for analyzing maximum no-effect concentration of chemical acting on organisms
  • Method for analyzing maximum no-effect concentration of chemical acting on organisms
  • Method for analyzing maximum no-effect concentration of chemical acting on organisms

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Determination of NOEC of Guole and Imidacloprid on Trichogramma

[0037] The first step is the acquisition of chronic toxicity test data. Obtain the data of chronic toxicity test of chemicals, including test design (treatment and repetition), concentration level and end-point effect of test substance, etc.

[0038] Trichogramma is one of the most widely used and most influential natural enemy insects at home and abroad. As an important means of controlling pests, chemical pesticides may also have toxic and side effects on their natural enemies while eliminating pests. The safety of pesticides to natural enemies was clarified by carrying out experiments on the chronic toxicity of pesticides to Trichogramma corn borer. In the experiment, Trichogramma was used as the test organism, dimethoate and imidacloprid were used as the test chemicals, and the end-point effects were egg production, eclosion rate and adult survival time. Each test substance test group has 6 treatme...

Embodiment 2

[0061] The first step is the acquisition of chronic toxicity test data.

[0062] Take the quail chronic toxicity (growth and reproduction) effect test as an example. The widespread use of pesticides in agricultural production has had a huge impact on birds that mainly forage on farmland. Birds exposed to low doses or slightly less toxic pesticides will not cause death, but their growth and reproduction behaviors will be affected. By evaluating the results of environmental toxicology model biological toxicity tests on birds, combined with field exposure levels, and extrapolating to the wild environment, the environmental risks of pesticides can be more fully understood.

[0063] In the experiment, quail was used as the test organism, acetamiprid and methacrylic acid were used as the test chemicals, and the end-point effects were body weight, average daily egg production and stillbirth ratio. Each test substance test group has 6 treatment concentrations (including 1 blank cont...

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Abstract

The invention provides a method for analyzing the maximum no-effect concentration of a chemical acting on organisms, belonging to the field of pesticide data analysis techniques. The method comprisesthe following steps of: 1) allowing a tested chemical with different concentrations to act on tested organisms for chronic toxicity tests, and carrying out measuring to obtain a plurality of groups ofend effect data; 2) classifying the plurality of groups of end effect data obtained in the step 1); (3) constructing a hypothesis testing model by utilizing the data classified in the step (2), selecting the highest concentration of the tested chemical which does not generate significant effect from the same group of end effect data according to a significance value result in the statistics of the hypothesis testing model, determine the highest concentration of the tested chemical as NOEC in the group, and in different groups of the end effect data, selecting the NOEC of a group with a minimum NOEC value as the maximum no-effect concentration of the tested chemical acting on the tested organisms. The analysis method provided by the invention can ensure analysis efficiency and accuracy.

Description

technical field [0001] The invention belongs to the technical field of pesticide data analysis, and in particular relates to an analysis method of the maximum no-effect concentration of chemicals on organisms. Background technique [0002] To study the toxic effect of chemicals is a necessary means to predict the safe exposure limit of chemicals, and the non-observed effect concentration (NOEC) is one of the important parameters. NOEC refers to the highest concentration of a test substance that has no significant effect on the test organisms within a certain period of time compared with the control. This index is an important index for evaluating the chronic toxicity effects of chemicals and an indispensable basis for formulating hygienic standards for chemicals. Since NOEC is very close to the threshold dose (minimum dose causing damage), reliable experimental data and sensitive and accurate statistical methods are required to support data analysis. In the prior art, comm...

Claims

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Application Information

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IPC IPC(8): G16C20/70
CPCG16C20/70A61K49/0008A61K49/0004G01N2333/4356G01N33/5014A61K35/64
Inventor 宋雯吴长兴周欣欣陈丽萍苍涛徐明飞张怡
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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