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Intelligent compound gestodene vaginal ring preparation with memory effect and application of intelligent compound gestodene vaginal ring preparation

A gestodene and vaginal ring technology is applied in the field of preparation of intelligent compound gestodene and ethinylestradiol vaginal ring, which can solve the problems such as no patent report on compound gestodene vaginal ring, etc., to ensure contraception effect, the effect of improving compliance

Inactive Publication Date: 2012-07-04
LIAONING AIMU MEDICAL SCI&TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no patent report on the compound gestodene vaginal ring

Method used

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  • Intelligent compound gestodene vaginal ring preparation with memory effect and application of intelligent compound gestodene vaginal ring preparation
  • Intelligent compound gestodene vaginal ring preparation with memory effect and application of intelligent compound gestodene vaginal ring preparation
  • Intelligent compound gestodene vaginal ring preparation with memory effect and application of intelligent compound gestodene vaginal ring preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 3.04g Gestodene and 9.12g PVP, prepare a solid dispersion by solvent method, mix it with 1kg silicone rubber and 1.17g ethinyl estradiol evenly, obtain the silicone rubber raw material containing medicine, put it into the extruder Put the blank silicone rubber into another extruder, co-extrude it into a double-layer tube, and heat and vulcanize it. The outer wall thickness of the obtained long tube is 200 μm, the outer diameter of the tube is 5 mm, and the inner diameter of the tube is 0.15 mm. The extruded double-layer tube is cut into 150 mm long pieces, a Ti-Ni memory alloy wire is inserted into it, and both ends of the double-layer tube are welded to form a compound vaginal ring containing gestodene and ethinyl estradiol.

Embodiment 2

[0024] Weigh 3.72g gestodene, 1.43g ethinyl estradiol and 22.32g PEG6000, prepare a solid dispersion by melting method, mix it with 1kg EVA evenly, obtain the EVA raw material containing medicine, put the above raw materials into extrusion In the machine; put the blank EVA into another extruder, and use co-extrusion to make a double-layer tube. The outer wall thickness of the tube is 120 μm, the outer diameter of the tube is 4 mm, and the inner diameter of the tube is 0.1 mm. The double-layered tube was cut into 157mm long pieces, the Ti-Ni memory alloy wire was inserted into it, and the two ends were welded to form a compound vaginal ring containing gestodene and ethinyl estradiol.

[0025] In vitro drug release test

[0026] Instrument: 1. HPLC Waters 2695vp

[0027] 2. Intelligent dissolution tester ZRS-8G

[0028] process:

[0029] 1. Take a nylon filament and fix the ring to be tested on the stirring paddle of the dissolution apparatus, use distilled water as the disso...

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PUM

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Abstract

The invention relates to a contraceptive, in particular to an intelligent compound gestodene vaginal ring preparation with a memory effect. A vaginal ring consists of a controlled release membrane, a gestodene / ethinyloestradiol-containing carrier and a shape memory material, and can slowly release a contraceptive at constant speed within 21 days. By implementing the preparation, the remarkable contraception effect can be achieved, the inconvenience caused by the oral administration of the contraceptive is avoided, and the appliance of the administration is improved.

Description

technical field [0001] The patent of the present invention belongs to the field of new intravaginal drug delivery system, which relates to the preparation and application of an intelligent compound gestodene and ethinyl estradiol vaginal ring with shape memory effect. Background technique [0002] With the continuous expansion of the population in my country and the world, it is imminent to actively adopt safe and effective contraceptive measures to control the population, improve the quality of the population and the health level of the whole people. The research on "safe and effective contraception" has become one of the "ten challenges" in the field of reproductive health "one. [0003] Synthetic steroid hormones have been used as contraceptives for 60 years. Initially, oral tablets were mainly used. Because they need to be taken regularly every day, the contraceptive effect of oral contraceptives is often affected by missed doses and vomiting, resulting in unintended pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F6/14A61M31/00A61K31/567A61P15/18
Inventor 陈国军付伟张莹宁美英武小锋段雪艳王佳庆刘颖
Owner LIAONING AIMU MEDICAL SCI&TECH
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