Vaginal acid-base buffer gel and preparation method thereof

Abstract

The invention provides a vaginal acid-base buffer gel and a preparation method thereof, and specifically relates to the pharmaceutical field. The vaginal acid-base buffer gel consists of the followingcomponents (by mass): 1%-39% of an oil phase, 60-99% of a water phase, 0.001-2% of a pH regulator and 0.05-5% of a bacteriostat, wherein the oil phase is white petrolatum or liquid paraffin or glyceryl behenate or Span or Tween or glycerol or propylene glycol; the water phase is hydroxypropyl methylcellulose or carbomer or sodium carboxymethylcellulose or polycarbophil or polyethylene glycol or azone or gelatin or purified water; the pH regulator is citric acid or sodium citrate or sodium hydroxide or hydrochloric acid or triethanolamine or boric acid or borax or sodium dihydrogen phosphate or disodium hydrogen phosphate; the bacteriostat is benzoic acid or sodium benzoate or benzyl alcohol or benzalkonium bromide or benzalkonium chloride or sorbic acid or potassium sorbate or nipalgin. The product prepared by the invention can effectively regulate the original vaginal environment of inflammation, remove vaginal odor and improve symptoms such as increased vaginal secretions or itching.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a vaginal acid-base buffer gel and a preparation method thereof. Background technique [0002] The vaginal pH of women of normal childbearing age is 3.8 to 4.5. This acidic environment is formed because of glycogen in the vaginal epithelial tissue and the presence of lactobacillus in the vaginal flora of women of childbearing age. Lactobacillus uses glycogen to produce lactic acid to maintain the acidic environment of the vagina and at the same time inhibit the growth of pathogens, which is called vaginal self-purification. Lactobacilli are also known as vaginal guards. [0003] Changes in vaginal pH can be a cause or a consequence of vaginal pathogenesis. Maintaining normal vaginal pH is an important guarantee for vaginal health; there are many microorganisms in the normal vagina, but due to the formation of ecological balance among these microorganisms in the vagina, they ...

AI Technical Summary

Problems solved by technology

[0004] For the above-mentioned diseases or symptoms, buffer gels are often used for treatment, but the existing buffer gels have the following deficiencies: 1. The product gel is soft in appearance and shape, cannot stay in the body for a long time, and is easy to flow out and pollute Underwear; 2. The effect of the product is not obvious in use, and the effect of adjuvant treatment of vaginitis is quite poor; 3. Patients with damaged vaginal mucosa have transient irritation and pain during use; 4. The price is inflated; Poor; the preparation process takes a long time, which may easily lead to oxidation and discoloration of the product;