A kind of vaginal acid-base buffer gel and its preparation method

Abstract

The invention provides a vaginal acid-base buffer gel and a preparation method, specifically relating to the field of pharmacy, which is composed of the following mass components: oil phase base 1% to 39%, water phase base 60% to 99%, acid-base adjustment Agent 0.001% to 2% and antibacterial agent 0.05% to 5%; oil phase base component is white petrolatum or liquid paraffin or glyceryl behenate or Span or Tween or glycerin or propylene glycol; water phase base component is Hypromellose or carbomer or sodium carboxymethylcellulose or polycarbophil or polyethylene glycol or azone or gelatin or purified water; acid-base regulator is citric acid or sodium citrate or sodium hydroxide or hydrochloric acid or triethanolamine or boric acid or borax or sodium dihydrogen phosphate or disodium hydrogen phosphate; the bacteriostatic agent is benzoic acid or sodium benzoate or benzyl alcohol or benzalkonium bromide or benzalkonium chloride or sorbic acid or Potassium sorbate or parabens. The product prepared by the invention can effectively regulate the original inflammatory vaginal environment, remove vaginal odor, and improve symptoms such as increased vaginal secretions or itching.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a vaginal acid-base buffer gel and a preparation method. Background technique [0002] The vaginal pH of women of normal reproductive age is 3.8 to 4.5, and this acidic environment is formed because of glycogen in the vaginal epithelium and the presence of lactobacilli in the vaginal flora of women of reproductive age. Lactobacilli use glycogen to produce lactic acid to maintain an acidic vaginal environment while inhibiting the growth of pathogens, known as vaginal self-purification. Lactobacilli are also known as vaginal guards. [0003] Changes in vaginal pH can be the cause of vaginal disease, or it can be the result of disease. Maintaining a normal vaginal pH is an important guarantee for vaginal health; there are many microorganisms in the normal vagina, but due to the ecological balance between these microorganisms in the vagina, they do not cause disease. Once the ec...

AI Technical Summary

Problems solved by technology

[0004] For the above-mentioned diseases or symptoms, buffer gels are often used for treatment, but the existing buffer gels have the following deficiencies: 1. The product gel is soft in appearance and shape, cannot stay in the body for a long time, and is easy to flow out and pollute Underwear; 2. The effect of the product is not obvious in use, and the effect of adjuvant treatment of vaginitis is quite poor; 3. Patients with damaged vaginal mucosa have transient irritation and pain during use; 4. The price is inflated; Poor; the preparation process takes a long time, which may easily lead to oxidation and discoloration of the product;