Pig blood deproteinized extract gel and preparation method thereof

Abstract

The invention discloses a pig blood deproteinized extract preparation, particularly relates to pig blood deproteinized extract gel, more particularly relates to a medicament for treating skin and eye inflammatory injuries caused by various reasons and a preparation method thereof, and belongs to the technical field of biological pharmacy, wherein the medicament is a novel preparation of a pig blood deproteinized extract. The pig blood deproteinized extract gel is prepared from the following raw material drugs in parts by weight: 20 to 50 parts of pig blood deproteinized extract solution, 2 to6 parts of methylcellulose, 10 to 15 parts of glycerol, and 0.2 to 0.5 part of methyl and ethyl hydroxybenzoate. Compared with similar bovine blood products, the medicament made from pig blood has the product advantages of high safety and high bioactivity. The pig blood deproteinized extract gel makes up potential hazards of bovine blood products, and the safety and curative effect of the pig blood deproteinized extract gel are remarkably higher than those of calf blood deproteinized gel.

Description

technical field [0001] The present invention relates to a porcine blood deproteinized extract preparation, in particular to a porcine blood deproteinized extract gel, and more specifically, to a medicine for treating skin and eye inflammation damage caused by various reasons and a preparation method thereof , which is a new dosage form of pig blood deproteinized extract, belonging to the technical field of biopharmaceuticals. Background technique [0002] Surgical wounds, burns, scalds, and diseases including bedsores, limb and skin ulcers are very common skin diseases. At present, there are many types of medicines and treatment methods for the treatment of diseases in this area. For large area I o -Ⅲ o The treatment of burns is exposure therapy, that is, treatment with lamp roasting or infrared radiation to reduce exudation and anti-infection. For small area burns, most of them use ointment, tincture, etc. to apply exposure or semi-exposure treatment. The shortcomings of ...

AI Technical Summary

Problems solved by technology

At present, there are many types of medicines and treatment methods for the treatment of diseases in this area. For large area I o -Ⅲ o The treatment of burns is exposure therapy, that is, treatment with lamp roasting or infrared radiation to reduce exudation and anti-infection. For small area burns, most of them use ointment, tincture, etc. to apply exposure or semi-exposure treatment. The shortcomings of these methods are anti-infection and Poor anti-exudation ability, long course of treatment, great pain, high scarring rate, high cost, especially the psychological disorder caused by long-term exposure to nakedness, which seriously affects sleep and appetite, and has a certain impact on wound healing

[0003] For ocular surface inflammation, antibiotics are generally used in combination with vitamins and trace hormones (including eye drops) for treatment. This treatment effect is not ideal, especially for acute inflammatory lesions, and for prolonged unhealed ocular surface ulcers (alkali burns) Ulcers, radiation ulcers and neurotrophic ulcers) and infectious ulcers have no satisfactory treatment, often causing loss of vision, resulting in permanent disability of the patient

[0004] At present, the drugs of the same kind to treat the above-mentioned wounds, burns, scalds and corneal injuries all use calf blood as the raw material to remove the protein extract. Sex and other factors, the World Health Organization strictly restricts the use of bovine blood raw material products, and the general public has a serious panic about bovine-derived biological products

Patent No. ZL200510083041.2, patent name "a gel of deproteinized calf blood extract" and patent No. ZL200810010480.4, patent name "ophthalmic preparation composition containing calf blood deproteinized extract", provide a A drug for the treatment of the above-mentioned diseases, but this technology uses calf blood as a raw material for protein-free extract pharmaceutical preparations. Due to the limitations of the mad cow disease detection method and the limitations of mad cow disease virus inactivation, the effect of the drug is not ideal. The clinical application is widely restricted; the gel preparation with calf blood as raw material only uses water-soluble gel matrix with poor lubricity, easy to lose water, and the active ingredients are easy to volatilize, so it can't exert the drug effect well, and its treatment time long, prolonging the suffering of the patient

[0005] Although the deproteinized pig blood extract has the effect of promoting the uptake of oxygen and glucose by cells, it cannot be directly used in clinical applications of patients, and the extract is an aqueous solution with difficult storage conditions. Once the power failure will directly affect its quality

Moreover, the existing pig blood deproteinized extract is an injection preparation, and its injection is mainly for the treatment of cerebrovascular diseases, and there is no report on the treatment of skin and eyeball inflammation damage.

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